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Blut1989; 58(3); 129-132; doi: 10.1007/BF00320431

Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.

Abstract: Tumorous amyloid deposits in the nasal mucosa of two horses differed from generalized AA-amyloidosis with respect to clinical features, organ distribution, and resistance to KMnO4 treatment. Using a panel of antibodies directed against different human amyloid fibril proteins and employing the peroxidase-anti-peroxidase (PAP) technique, we showed the described equine amyloid to be A lambda-type, as demonstrated by immunohistochemical cross-reactivity. Consequently, we identified a second amyloid class in horses and showed that immunoglobulin light-chain-derived amyloid may also be present in animals.
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Publication Date: 1989-03-01 PubMed ID: 2495038DOI: 10.1007/BF00320431Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article describes a study where a type of amyloidosis – Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) – was identified in two horses. This type of amyloidosis, previously unknown in animals, was found to have unique characteristics compared to the commonly-found AA-amyloidosis, shedding light on a new class of this disease in the animal kingdom.

Study Background

  • The study investigated unusual tumorous amyloid deposits found in the nasal mucosa of two horses. These were markedly different from the general AA-amyloidosis found commonly in horses.
  • This posed an interesting proposition, leading the researchers to investigate if this was a different type of amyloidosis altogether.

Methodology

  • To confirm this, the researchers used antibodies directed against different human amyloid fibril proteins as the enforced peroxidase-anti-peroxidase (PAP) technique, a common practice in histology to identify specific antigens.
  • Further, they studied the resistance of these deposits to KMnO4 treatment – a characteristic feature of some types of amyloidosis.
  • These procedures would help determine if these deposits represented a different type of amyloidosis and if there was a cross-reactivity to the antibodies.

Findings

  • Upon performing these tests, the researchers found that the amyloid deposits were indeed different from typical AA-amyloidosis. The deposits displayed cross-reactivity to the antibodies used, signifying that they were of a different origin.
  • These were confirmed to be Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda), a type of amyloidosis hitherto known only in humans.

Implications

  • The discovery of this form of amyloidosis in horses broadens the understanding of this disease in animals. This is significant as this could affect diagnostic and therapeutic strategies in veterinary medicine.
  • Notably, this research identifies a second class of amyloidosis in horses, expanding the known range of this disease in the animal kingdom.

Cite This Article

APA
Linke RP, Trautwein G. (1989). Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses. Blut, 58(3), 129-132. https://doi.org/10.1007/BF00320431

Publication

Blut
ISSN: 0006-5242
NlmUniqueID: 0173401
Country: Germany
Language: English
Volume: 58
Issue: 3
Pages: 129-132

Researcher Affiliations

Linke, R P
  • Institut für Immunologie, Universität München, Federal Republic of Germany.
Trautwein, G

    MeSH Terms

    • Amyloid / analysis
    • Amyloid / immunology
    • Amyloidosis / complications
    • Amyloidosis / immunology
    • Animals
    • Cross Reactions
    • Female
    • Horse Diseases / immunology
    • Horse Diseases / metabolism
    • Horse Diseases / pathology
    • Horses
    • Humans
    • Immunoglobulin lambda-Chains / analysis
    • Immunohistochemistry
    • Male
    • Nasal Mucosa / analysis
    • Nasal Mucosa / pathology
    • Nose Neoplasms / analysis
    • Nose Neoplasms / complications
    • Nose Neoplasms / veterinary

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    Citations

    This article has been cited 1 times.
    1. Østevik L, Gunnes G, de Souza GA, Wien TN, Sørby R. Nasal and ocular amyloidosis in a 15-year-old horse. Acta Vet Scand 2014 Aug 27;56(1):50.
      doi: 10.1186/s13028-014-0050-6pubmed: 25159190google scholar: lookup
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