Immunoglobulins and secretory component in the external secretions of foals with combined immunodeficiency.
Abstract: Nasal washings and tears were collected from seven Arabian foals with combined immunodeficiency and nine normal foals. The major immunoglobulin in the external secretions of normal foals over 2 months of age was secretory immunoglobulin A, whereas foals with combined immunodeficiency lacked this immunoglobulin. The external secretions of both normal and immunodeficient foals contained free secretory component at birth.
Publication Date: 1978-02-01 PubMed ID: 631895PubMed Central: PMC414135DOI: 10.1128/iai.19.2.695-698.1978Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research article is about a study conducted on Arabian foals with combined immunodeficiency, comparing their immunoglobulin and secretory component levels found in nasal washings and tears to those of normal foals. The investigation revealed a lack of secretory immunoglobulin A in immunodeficient foals over two months old.
Immunodeficiency in Foals
- The main objective of this research was to investigate the presence and levels of immunoglobulins, specifically secretory immunoglobulin A, in Arabian foals diagnosed with combined immunodeficiency. Immunodeficiency is a state in which the immune system’s ability to fight infectious disease and cancer is compromised or entirely absent. In this case, foals are the subjects of the study, and a comparison is made between normal (healthy) and combined immunodeficient foals.
Methods of Study
- To conduct the research, the scientists collected nasal washings and tears from two groups of foals, seven with combined immunodeficiency and nine normal ones. These samples served as the primary source of data collection, providing the needed information about the presence and absence of specific immunoglobulins in the subjects.
Findings of the Study
- The investigators discovered that the major immunoglobulin found in the external secretions (nasal washings and tears) of normal foals over 2 months old was secretory immunoglobulin A. This component plays a crucial role in mucosal immunity, preventing pathogens from adhering to and penetrating the mucous membranes.
- However, surprisingly, foals with combined immunodeficiency lacked this specific immunoglobulin. This indicates a failing in their normal immune response and underscores the function of secretory immunoglobulin A in maintaining healthy immunity.
- Interesting to note, both normal and immunodeficient foals contained free secretory components at birth, showing no initial difference between the two groups.
Significance of the Study
- This research could potentially serve as an important milestone in diagnosing and understanding the interaction between immunodeficiency and the potential lack of specific immunoglobulins, like secretory immunoglobulin A. This understanding can be utilized in developing effective treatments or preventive measures for foals with combined immunodeficiency.
Cite This Article
APA
Buening GM, Perryman LE, McGuire TC.
(1978).
Immunoglobulins and secretory component in the external secretions of foals with combined immunodeficiency.
Infect Immun, 19(2), 695-698.
https://doi.org/10.1128/iai.19.2.695-698.1978 Publication
Researcher Affiliations
MeSH Terms
- Age Factors
- Animals
- Animals, Newborn
- Horse Diseases / immunology
- Horses
- Immunoglobulin A / biosynthesis
- Immunoglobulin Fragments / biosynthesis
- Immunologic Deficiency Syndromes / immunology
- Immunologic Deficiency Syndromes / veterinary
- Nasal Mucosa / metabolism
- Secretory Component / biosynthesis
- Tears / immunology
References
This article includes 17 references
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- McGuire TC, Crawford TB. Identification and quantitation of equine serum and secretory immunoglobulin A.. Infect Immun 1972 Oct;6(4):610-5.
- Tomasi TB Jr, Bienenstock J. Secretory immunoglobulins.. Adv Immunol 1968;9:1-96.
- McGuire TC, Poppie MJ, Banks KL. Combined (B- and T-lymphocyte) immunodeficiency: a fatal genetic disease in Arabian foals.. J Am Vet Med Assoc 1974 Jan 1;164(1):70-6.
- Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells.. J Immunol 1974 Apr;112(4):1553-9.
- McGuire TC, Poppie MJ. Hypogammaglobulinemia and thymic hypoplasia in horses: a primary combined immunodeficiency disorder.. Infect Immun 1973 Aug;8(2):272-7.
- Pahud JJ, Mach JP. Equine secretory IgA and secretory component.. Int Arch Allergy Appl Immunol 1972;42(2):175-86.
- Allen WD, Porter P. Localization by immunofluorescence of secretory component and IgA in the intestinal mucosa of the young pig.. Immunology 1973 Feb;24(2):365-74.
- Thomasi TB Jr. Secretory immunoglobulins.. N Engl J Med 1972 Sep 7;287(10):500-6.
- Thompson DB, Studdert MJ, Beilharz RG, Littlejohns IR. Inheritance of a lethal immunodeficiency disease of Arabian foals.. Aust Vet J 1975 Mar;51(3):109-13.
- Loening UE. The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.. Biochem J 1967 Jan;102(1):251-7.
- McGuire TC, Banks KL, Poppie MJ. Combined immunodeficiency in horses: characterization of the lymphocyte defect.. Clin Immunol Immunopathol 1975 Mar;3(4):555-66.
- Bradley PA, Bourne FJ, Brown PJ. The respiratory tract immune system in the pig. I. Distribution of immunoglobulin-containing cells in the respiratory tract mucosa.. Vet Pathol 1976;13(2):81-9.
- McGuire TC, Banks KL, Davis WC. Alterations of the thymus and other lymphoid tissue in young horses with combined immunodeficiency.. Am J Pathol 1976 Jul;84(1):39-54.
- McGuire TC, Banks KL, Poppie MJ. Animal model of human disease. Combined immunodeficiency (severe), Swiss-type agammaglobulinemia.. Am J Pathol 1975 Sep;80(3):551-4.
- Vaerman JP, Querinjean P, Heremans JF. Studies on the IgA system of the horse.. Immunology 1971 Sep;21(3):443-54.
- Porter P, Noakes DE. Immunoglobulin IgA in bovine serum and external secretions.. Biochim Biophys Acta 1970 Jul 27;214(1):107-16.
Citations
This article has been cited 1 times.- Magnuson NS, Perryman LE. In vitro of adenosine on lymphocytes and erythrocytes from horses with combined immunodeficiency.. J Clin Invest 1979 Jul;64(1):89-101.
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