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Home / Equine Research Bank / Vet Parasitol / Impaired efficacy of ivermectin against Parascaris equorum, ...
Veterinary parasitology2011; 182(2-4); 372-377; doi: 10.1016/j.vetpar.2011.05.045

Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland.

Abstract: In order to assess the resistance situation against macrocyclic lactones in Parascaris equorum and against tetrahydropyrimidine derivatives in strongyles in Finnish trotter horses, 112 foals on 18 farms, mostly 1 year old, were examined for these parasites with a modified McMaster faecal flotation method. P. equorum positive foals (n=24) were given ivermectin orally at a dose of 200 μg/kg b.w., while strongyle positive but P. equorum negative foals (n=38) received pyrantel embonate orally at a dose of 19 mg/kg. Sixteen P. equorum infected foals, treated with ivermectin, also harboured strongyles. During the anthelmintic treatment visit to the farm, Faecal Egg Count Reduction Test (FECRT) reference (first) samples were collected. Fourteen days later, the second sampling (reduction samples) was done. The FECR was calculated for each foal/parasite combination. The reduction efficacies of ivermectin against P. equorum (mean 52%, calculated from the individual egg count reductions) and pyrantel against strongyles (43%) were strongly indicative of widespread resistance. Also indication of ivermectin resistance among strongyles was seen. The widespread use of anthelmintics for Finnish horses obviously has resulted in resistance, as has happened elsewhere, too.
Copyright © 2011 Elsevier B.V. All rights reserved.
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Publication Date: 2011-05-31 PubMed ID: 21689886DOI: 10.1016/j.vetpar.2011.05.045Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on assessing the resistance of certain parasites in Finnish trotter horses against specific treatments and discovering widespread resistance. The findings indicate that both ivermectin against Parascaris equorum, and ivermectin and pyrantel against strongyles, have reduced effectiveness.

Research Context and Objectives

  • The study aims to assess the resistance situation against specific anthelmintic drugs, namely, macrocyclic lactones, and tetrahydropyrimidine derivatives in Finnish trotter horses. The drugs in focus are ivermectin—used primarily against Parascaris equorum—and pyrantel—used against strongyles.
  • The research involves examining 112 foals, mostly one year old, from 18 different farms in Finland for these parasites using a modified McMaster faecal flotation method. This method is a common choice for parasite detection in fecal matters.

Methodology and Process

  • Foals testing positive for P. equorum received doses of ivermectin orally, while those positive for strongyles but negative for P. equorum received oral doses of pyrantel embonate.
  • The researchers carried out the Faecal Egg Count Reduction Test (FECRT) during the anthelmintic treatment visit to the farms; this acted as the reference (first) samples. Subsequently, fourteen days later, the second sampling (reduction samples) took place.
  • The Faecal Egg Count Reduction (FECR) was calculated for every foal/parasite combination to determine the efficiency of the administered anthelmintic drugs.

Findings and Conclusion

  • The researchers observed reduced efficiacies of ivermectin against P. equorum, and of pyrantel against strongyles, indicative of widespread resistance.
  • There were even indications of ivermectin resistance among the strongyles.
  • The conclusion drawn from the study suggests that the widespread use of these treatments has likely led to the development of resistance similar to what has been observed in other parts of the world as well.

Cite This Article

APA
Näreaho A, Vainio K, Oksanen A. (2011). Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. Vet Parasitol, 182(2-4), 372-377. https://doi.org/10.1016/j.vetpar.2011.05.045

Publication

Veterinary parasitology
ISSN: 1873-2550
NlmUniqueID: 7602745
Country: Netherlands
Language: English
Volume: 182
Issue: 2-4
Pages: 372-377

Researcher Affiliations

Näreaho, A
  • Department of Veterinary Biosciences, Faculty of Veterinary Medicine (FINPAR), PO Box 66, 00014 University of Helsinki, Finland. anu.nareaho@helsinki.fi
Vainio, K
    Oksanen, A

      MeSH Terms

      • Animals
      • Anthelmintics / therapeutic use
      • Ascaridida Infections / drug therapy
      • Ascaridida Infections / parasitology
      • Ascaridida Infections / veterinary
      • Ascaridoidea / drug effects
      • Drug Resistance
      • Horse Diseases / drug therapy
      • Horse Diseases / epidemiology
      • Horse Diseases / parasitology
      • Horses
      • Ivermectin / therapeutic use
      • Pyrantel / therapeutic use
      • Strongylida / drug effects
      • Strongylida Infections / drug therapy
      • Strongylida Infections / parasitology
      • Strongylida Infections / veterinary

      Citations

      This article has been cited 18 times.
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