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Home / Equine Research Bank / Acta Vet Scand / ImproWin® in the treatment of gastric ulceration of the squ...
Acta veterinaria Scandinavica2014; 56(1); 13; doi: 10.1186/1751-0147-56-13

ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.

Abstract: Gastric ulceration is highly prevalent in horses, and there is a large commercial market for feed-additives and non-licenced products that claim effect for prevention and treatment of gastric ulceration. ImproWin® has been used as a feed additive in horses with anecdotal evidence that it may have some positive effects on gastric ulceration.The aim of this study was to investigate the effect of ImproWin® treatment on spontaneously occurring gastric ulcers of the squamous mucosa in Standardbred and Coldblooded trotting racehorses. The study was performed as a randomised, double-blinded, single centre study with stratified semi cross-over design with breed as stratification factors. The horses were clinically and endoscopically examined prior to start and after three weeks of treatment. The ulcerations were scored in accordance with Equine Gastric Ulcer Council (EGUC) recommendations on a 5 point scale and on a 10 cm Visual Analogue Scale (VAS). The patients were responder-classified after 3 weeks. Responders in need of ulcer treatment were randomly allocated to 2 or 4 weeks of additional treatment. Non-responders to placebo were crossed to ImproWin®. Results: The 5-point EGUC score and VAS recorded score was significantly reduced (P ≤ 0.01) in both groups after 3 weeks of treatment. From 3 weeks to the end of treatment the score was further significantly reduced in the ImproWin® group (P ≤ 0.05). At the end of treatment, 78% in the ImproWin® group and 54.8% in the placebo group were classified as responders. The difference was significant (P = 0.04). Conclusions: ImproWin® may aid the healing process of ulcers of the gastric squamous mucosa of trotters.
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Publication Date: 2014-03-13 PubMed ID: 24625291PubMed Central: PMC4008370DOI: 10.1186/1751-0147-56-13Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the impact of ImproWin®, a non-licenced product and feed additive, on gastric ulcers in trotting racehorses. The results show that ImproWin® significantly reduced ulcer scores, suggesting its potential to aid in the healing of such ulcers.

Study Design

  • The researchers designed a randomised, double-blinded, single-centre study with a semi cross-over design where the breed was taken as the stratification factors.
  • Standardbred and Coldblooded trotting racehorses with spontaneous gastric ulcers were chosen to participate in this study.
  • Each horse was clinically and endoscopically examined both before and after a three-week treatment period.
  • The researchers scored the ulcers based on the Equine Gastric Ulcer Council (EGUC) recommendations on a 5 point scale and on a 10 cm Visual Analogue Scale (VAS).

Response Classification and Further Treatment

  • After the initial three-week treatment period, the horses were classified as responders or non-responders.
  • Responders requiring further ulcer treatment were then randomly assigned to an additional treatment period of either 2 or 4 weeks.
  • Non-responders who received placebo treatment were switched over to receive the ImproWin® treatment.

Results and Conclusions

  • After the three-week treatment, both the EGUC score and the VAS score were significantly reduced (P ≤ 0.01) in both treatment groups.
  • From the three-week mark onwards, the scores continued to decrease significantly (P ≤ 0.05) in the group being treated with ImproWin®.
  • At the end of the treatment period, 78% of the horses in the ImproWin® group were classified as responders, compared to 54.8% in the placebo group – a statistically significant difference (P = 0.04).
  • The study concludes that ImproWin® might help in the healing process of gastric ulcers in trotting racehorses.

Cite This Article

APA
Hellings IR, Larsen S. (2014). ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand, 56(1), 13. https://doi.org/10.1186/1751-0147-56-13

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 56
Issue: 1
Pages: 13

Researcher Affiliations

Hellings, Ingunn R
  • Rikstotoklinikken Bjerke AS, Postboks 194, Økern, N-0150 Oslo, Norway. Ingunn.risnes@rikstoto.no.
Larsen, Stig

    MeSH Terms

    • Acids / administration & dosage
    • Acids / therapeutic use
    • Animal Feed / analysis
    • Animals
    • Anti-Ulcer Agents / administration & dosage
    • Anti-Ulcer Agents / therapeutic use
    • Cross-Over Studies
    • Diet / veterinary
    • Dietary Supplements / analysis
    • Double-Blind Method
    • Female
    • Gastric Mucosa / drug effects
    • Horse Diseases / drug therapy
    • Horse Diseases / etiology
    • Horses
    • Male
    • Norway
    • Physical Conditioning, Animal
    • Stomach Ulcer / drug therapy
    • Stomach Ulcer / etiology
    • Stomach Ulcer / veterinary
    • Vitamin B Complex / administration & dosage
    • Vitamin B Complex / therapeutic use

    References

    This article includes 44 references
    1. Rooney JR. Gastric ulceration in foals.. Vet Pathol 1964;56:497–503.
    2. Begg LM, O'Sullivan CB. The prevalence and distribution of gastric ulceration in 345 racehorses.. Aust Vet J 2003;56:199–201.
      doi: 10.1111/j.1751-0813.2003.tb11469.xpubmed: 15080440google scholar: lookup
    3. Al Jassim RA, Scott PT, Trebbin AL, Trott D, Pollitt CC. The genetic diversity of lactic acid producing bacteria in the equine gastrointestinal tract.. FEMS Microbiol Lett 2005;56:75–81.
      doi: 10.1016/j.femsle.2005.05.023pubmed: 15953698google scholar: lookup
    4. Johnson B, Carlson GB, Vatistas NJ, Snyder JR, Lloyd KL, Koobs J. Investigations of the number and location of gastric ulcerations in horses in race training submitted to the Californian racehorse postmortem program.. Proc Am Ass Equine Practnrs 1994;56:123–124.
    5. Bell RJ, Kingston JK, Mogg TD, Perkins NR. The prevalence of gastric ulceration in racehorses in New Zealand.. N Z Vet J 2007;56:13–18.
      doi: 10.1080/00480169.2007.36729pubmed: 17339911google scholar: lookup
    6. Dionne RM, Vrins A, Doucet MY, Pare J. Gastric ulcers in standardbred racehorses: prevalence, lesion description, and risk factors.. J Vet Intern Med 2003;56:218–222.
      doi: 10.1111/j.1939-1676.2003.tb02437.xpubmed: 12683624google scholar: lookup
    7. Jonsson H, Egenvall A. Prevalence of gastric ulceration in Swedish Standardbreds in race training.. Equine Vet J 2006;56:209–213.
      pubmed: 16706273
    8. Murray MJ, Eichorn ES, Holste JE, Cox JL, Stanier WB, Cooper WL, Cooper VA. Safety, acceptability and endoscopic findings in foals and yearling horses treated with a paste formulation of omeprazole for twenty-eight days.. Equine Vet J Suppl 1999;56:67–70.
      pubmed: 10696298
    9. Andrews FM, Sifferman RL, Bernard W, Hughes FE, Holste JE, Daurio CP, Alva R, Cox JL. Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses.. Equine Vet J Suppl 1999;56:81–86.
      pubmed: 10696301
    10. Murray MJ, Haven ML, Eichorn ES, Zhang D, Eagleson J, Hickey GJ. Effects of omeprazole on healing of naturally-occurring gastric ulcers in thoroughbred racehorses.. Equine Vet J 1997;56:425–429.
      doi: 10.1111/j.2042-3306.1997.tb03153.xpubmed: 9413713google scholar: lookup
    11. MacAllister CG, Sifferman RL, McClure SR, White GW, Vatistas NJ, Holste JE, Ericcson GF, Cox JL. Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial.. Equine Vet J Suppl 1999. pp. 77–80.
      pubmed: 10696300
    12. Nieto JE, Spier SJ, van Hoogmoed L, Pipers F, Timmerman B, Snyder JR. Comparison of omeprazole and cimetidine in healing of gastric ulcers and prevention of recurrence in horses.. Equine Vet Edu 2001;56:260–264.
    13. Lester GD, Smith RL, Robertson ID. Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing thoroughbreds.. J Am Vet Med Assoc 2005;56:1636–1639.
      doi: 10.2460/javma.2005.227.1636pubmed: 16313043google scholar: lookup
    14. Geor RJ, Petrie L, Papich MG, Rousseaux C. The protective effects of sucralfate and ranitidine in foals experimentally intoxicated with phenylbutazone.. Can J Vet Res 1989;56:231–238.
      pmc: PMC1255552pubmed: 2713788
    15. Borne AT, MacAllister CG. Effect of sucralfate on healing of subclinical gastric ulcers in foals.. J Am Vet Med Assoc 1993;56:1465–1468.
      pubmed: 8496102
    16. Clark CK, Merritt AM, Burrow JA, Steible CK. Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses.. J Am Vet Med Assoc 1996;56:1687–1691.
      pubmed: 8641951
    17. Venner M, Lauffs S, Deegen E. Treatment of gastric lesions in horses with pectin-lecithin complex.. Equine Vet J Suppl 1999;56:91–96.
      pubmed: 10696303
    18. Ferrucci F, Zucca E, Croci C, Di FV, Ferro E. Treatment of gastric ulceration in 10 standardbred racehorses with a pectin-lecithin complex.. Vet Rec 2003;56:679–681.
      doi: 10.1136/vr.152.22.679pubmed: 12803394google scholar: lookup
    19. Murray MJ, Grady TC. The effect of a pectin-lecithin complex on prevention of gastric mucosal lesions induced by feed deprivation in ponies.. Equine Vet J 2002;56:195–198.
      pubmed: 11902762
    20. Murray MJ. Equine model of inducing ulceration in alimentary squamous epithelial mucosa.. Dig Dis Sci 1994;56:2530–2535.
      doi: 10.1007/BF02087686pubmed: 7995175google scholar: lookup
    21. Andrews FM, Bernard W, Byars D, Cohen N, Divers T, MacAllister CG, McGladdery A, Merritt AM, Merritt AM, Murray MJ. Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (EGUS): The Equine Gastric Ulcer Council.. Equine Vet Edu 1999;56:262–272.
    22. Carlsen KH, Kramer J, Fagertun HE, Larsen S. Loratadine and terfenadine in perennial allergic rhinitis. Treatment of non-responders to the drug with the other drug.. Allergy 1993;56:431–436.
      pubmed: 8238798
    23. Pockcock SJ. Clinical Trials; A Practical Approach. 7. Chichester, West Sussex: John Wiley & sons; 1989.
    24. Aabakken L, Larsen S, Osnes M. Visual analogue scales for endoscopic evaluation of nonsteroidal anti-inflammatory drug-induced mucosal damage in the stomach and duodenum.. Scand J Gastroenterol 1990;56:443–448.
      doi: 10.3109/00365529009095513pubmed: 2193376google scholar: lookup
    25. Altman DG. Practical Statistics for Medical Research. 3. London: Chapman&Hall; 1991.
    26. Agresti A. Categorical Data Analysis. 2. New Jersey: John Wiley & sons; 2002.
    27. Kleinbaum DG, Kupper LL, Muller A, Nizam A. Applied Regression Analysis and Other Multivariable Methods. 3. North Scituate, Mass: Duxbury Press Pacific Grove; 1988.
    28. Murray MJ, Eichorn ES. Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confinement with ad libitum access to hay on gastric ulceration in horses.. Am J Vet Res 1996;56:1599–1603.
      pubmed: 8915437
    29. Lorenzo-Figueras M, Merritt AM. Effects of exercise on gastric volume and pH in the proximal portion of the stomach of horses.. Am J Vet Res 2002;56:1481–1487.
      doi: 10.2460/ajvr.2002.63.1481pubmed: 12428654google scholar: lookup
    30. White G, McClure SR, Sifferman R, Holste JE, Fleishman C, Murray MJ, Cramer LG. Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration.. J Am Vet Med Assoc 2007;56:1680–1682.
      doi: 10.2460/javma.230.11.1680pubmed: 17542738google scholar: lookup
    31. Husted L, Sanchez LC, Olsen SN, Baptiste KE, Merritt AM. Effect of paddock vs. stall housing on 24 hour gastric pH within the proximal and ventral equine stomach.. Equine Vet J 2008;56:337–341.
      doi: 10.2746/042516408X284673pubmed: 18267880google scholar: lookup
    32. Luthersson N, Nielsen KH, Harris P, Parkin TD. Risk factors associated with equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark.. Equine Vet J 2009;56:625–630.
      doi: 10.2746/042516409X441929pubmed: 19927579google scholar: lookup
    33. Nadeau JA, Andrews FM, Mathew AG, Argenzio RA, Blackford JT, Sohtell M, Saxton AM. Evaluation of diet as a cause of gastric ulcers in horses.. Am J Vet Res 2000;56:784–790.
      doi: 10.2460/ajvr.2000.61.784pubmed: 10895901google scholar: lookup
    34. Nadeau JA. Management strategies for gastric ulcers. Proceedings of the 4th Mid-Atlantic Nutrition Conference. 2006. pp. 65–69.
    35. Canibe N, Steien SH, Overland M, Jensen BB. Effect of K-diformate in starter diets on acidity, microbiota, and the amount of organic acids in the digestive tract of piglets, and on gastric alterations.. J Anim Sci 2001;56:2123–2133.
      pubmed: 11518221
    36. Knarreborg A, Miquel N, Granli T, Jensen BB. Establishment and application of an in vitro methodology to study the effects of organic acids on coliform and lactic acid bacteria in the proximal part of the gastrointestinal tract of piglets.. Anim Feed Sci Tech 2002;56:131–140.
      doi: 10.1016/S0377-8401(02)00069-Xgoogle scholar: lookup
    37. Overland M, Granli T, Kjos NP, Fjetland O, Steien SH, Stokstad M. Effect of dietary formates on growth performance, carcass traits, sensory quality, intestinal microflora, and stomach alterations in growing-finishing pigs.. J Anim Sci 2000;56:1875–1884.
      pubmed: 10907830
    38. Partanen KH, Mroz Z. Organic acids for performance enhancement in pig diets.. Nutr Res Rev 1999;56:117–145.
      doi: 10.1079/095442299108728884pubmed: 19087448google scholar: lookup
    39. Roberts D, Majorie CC. In: Basic Principle of Organic Acids. 2. Benjamin WA, editor. Menlo Park, CA: ISBN; 1979. Carboxylic acids and their derivatives; pp. 788–861.
    40. Mroz Z, Overland M, Reese DE, Granli T, Kogut J, Kjeldsen KC. In: In Proceedings of the Second International Symposium on Digestive Physiology in Pigs. Banff, Canada. Ball RO, editor. Banff, Alberta, Canada; 2003. Duodeno-jejunal changes in the acidity and concentrations of formate, lactate and minerals as affected by potassium diformate and formic acid in diets for weaned piglets; pp. 177–179.
    41. Contreras M, Morales A, Garcia-Amado MA, De VM, Bermudez V, Gueneau P. Detection of Helicobacter-like DNA in the gastric mucosa of thoroughbred horses.. Lett Appl Microbiol 2007;56:553–557.
      doi: 10.1111/j.1472-765X.2007.02227.xpubmed: 17908231google scholar: lookup
    42. Elliott SN, Buret A, McKnight W, Miller MJ, Wallace JL. Bacteria rapidly colonize and modulate healing of gastric ulcers in rats.. Am J Physiol 1998;56:G425–G432.
      pubmed: 9724253
    43. Satoh HIRO, Guth PH, Grossman MI. Role of bacteria in gastric ulceration produced by indornethacin in the rat: cytoprotective action of antibiotics.. Gastroenterology 1983;56:483–489.
      pubmed: 6822322
    44. Argenzio RA, Eisemann J. Mechanisms of acid injury in porcine gastroesophageal mucosa.. Am J Vet Res 1996;56:564–573.
      pubmed: 8712526
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