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Acta veterinaria Scandinavica2014; 56(1); 13; doi: 10.1186/1751-0147-56-13

ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.

Abstract: Gastric ulceration is highly prevalent in horses, and there is a large commercial market for feed-additives and non-licenced products that claim effect for prevention and treatment of gastric ulceration. ImproWin® has been used as a feed additive in horses with anecdotal evidence that it may have some positive effects on gastric ulceration.The aim of this study was to investigate the effect of ImproWin® treatment on spontaneously occurring gastric ulcers of the squamous mucosa in Standardbred and Coldblooded trotting racehorses. The study was performed as a randomised, double-blinded, single centre study with stratified semi cross-over design with breed as stratification factors. The horses were clinically and endoscopically examined prior to start and after three weeks of treatment. The ulcerations were scored in accordance with Equine Gastric Ulcer Council (EGUC) recommendations on a 5 point scale and on a 10 cm Visual Analogue Scale (VAS). The patients were responder-classified after 3 weeks. Responders in need of ulcer treatment were randomly allocated to 2 or 4 weeks of additional treatment. Non-responders to placebo were crossed to ImproWin®. Results: The 5-point EGUC score and VAS recorded score was significantly reduced (P ≤ 0.01) in both groups after 3 weeks of treatment. From 3 weeks to the end of treatment the score was further significantly reduced in the ImproWin® group (P ≤ 0.05). At the end of treatment, 78% in the ImproWin® group and 54.8% in the placebo group were classified as responders. The difference was significant (P = 0.04). Conclusions: ImproWin® may aid the healing process of ulcers of the gastric squamous mucosa of trotters.
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Publication Date: 2014-03-13 PubMed ID: 24625291PubMed Central: PMC4008370DOI: 10.1186/1751-0147-56-13Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the impact of ImproWin®, a non-licenced product and feed additive, on gastric ulcers in trotting racehorses. The results show that ImproWin® significantly reduced ulcer scores, suggesting its potential to aid in the healing of such ulcers.

Study Design

  • The researchers designed a randomised, double-blinded, single-centre study with a semi cross-over design where the breed was taken as the stratification factors.
  • Standardbred and Coldblooded trotting racehorses with spontaneous gastric ulcers were chosen to participate in this study.
  • Each horse was clinically and endoscopically examined both before and after a three-week treatment period.
  • The researchers scored the ulcers based on the Equine Gastric Ulcer Council (EGUC) recommendations on a 5 point scale and on a 10 cm Visual Analogue Scale (VAS).

Response Classification and Further Treatment

  • After the initial three-week treatment period, the horses were classified as responders or non-responders.
  • Responders requiring further ulcer treatment were then randomly assigned to an additional treatment period of either 2 or 4 weeks.
  • Non-responders who received placebo treatment were switched over to receive the ImproWin® treatment.

Results and Conclusions

  • After the three-week treatment, both the EGUC score and the VAS score were significantly reduced (P ≤ 0.01) in both treatment groups.
  • From the three-week mark onwards, the scores continued to decrease significantly (P ≤ 0.05) in the group being treated with ImproWin®.
  • At the end of the treatment period, 78% of the horses in the ImproWin® group were classified as responders, compared to 54.8% in the placebo group – a statistically significant difference (P = 0.04).
  • The study concludes that ImproWin® might help in the healing process of gastric ulcers in trotting racehorses.

Cite This Article

APA
Hellings IR, Larsen S. (2014). ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand, 56(1), 13. https://doi.org/10.1186/1751-0147-56-13

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 56
Issue: 1
Pages: 13

Researcher Affiliations

Hellings, Ingunn R
  • Rikstotoklinikken Bjerke AS, Postboks 194, Økern, N-0150 Oslo, Norway. Ingunn.risnes@rikstoto.no.
Larsen, Stig

    MeSH Terms

    • Acids / administration & dosage
    • Acids / therapeutic use
    • Animal Feed / analysis
    • Animals
    • Anti-Ulcer Agents / administration & dosage
    • Anti-Ulcer Agents / therapeutic use
    • Cross-Over Studies
    • Diet / veterinary
    • Dietary Supplements / analysis
    • Double-Blind Method
    • Female
    • Gastric Mucosa / drug effects
    • Horse Diseases / drug therapy
    • Horse Diseases / etiology
    • Horses
    • Male
    • Norway
    • Physical Conditioning, Animal
    • Stomach Ulcer / drug therapy
    • Stomach Ulcer / etiology
    • Stomach Ulcer / veterinary
    • Vitamin B Complex / administration & dosage
    • Vitamin B Complex / therapeutic use

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    Citations

    This article has been cited 4 times.
    1. Vokes J, Lovett A, Sykes B. Equine Gastric Ulcer Syndrome: An Update on Current Knowledge. Animals (Basel) 2023 Apr 5;13(7).
      doi: 10.3390/ani13071261pubmed: 37048517google scholar: lookup
    2. Lo Feudo CM, Stucchi L, Conturba B, Stancari G, Zucca E, Ferrucci F. Equine Gastric Ulcer Syndrome affects fitness parameters in poorly performing Standardbred racehorses. Front Vet Sci 2022;9:1014619.
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    3. Huang G, Fang N, Kuang MQ, Huang YQ, Zhang KH. Establishment of a risk assessment system for peptic ulcer recurrence and its value in individualized intervention. Am J Transl Res 2021;13(4):2969-2975.
      pubmed: 34017463
    4. Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
      doi: 10.1111/jvim.13578pubmed: 26340142google scholar: lookup
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