Journal of the American Veterinary Medical Association2005; 227(10); 1636-1639; doi: 10.2460/javma.2005.227.1636

Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds.

Abstract: To compare the effects of oral administration of omeprazole and ranitidine on gastric squamous ulceration in Thoroughbreds in race training. Methods: Modified crossover study. Methods: 60 Thoroughbreds in race training with gastric squamous mucosal ulceration. Methods: Horses were randomly allocated into 3 groups. Group 1 received no treatment for 28 days followed by administration of omeprazole (4 mg/kg [1.8 mg/lb], PO, once daily) for 28 days; group 2 received omeprazole (4 mg/kg, PO, once daily) for 28 days followed by no treatment for 28 days; and group 3 received ranitidine (6.6 mg/kg [3.0 mg/lb], PO, q 8 h) for 28 days followed by administration of omeprazole (4 mg/kg, PO, once daily) for 28 days. Ulceration was assessed endoscopically at days 0, 28, 42, and 56. Lesions were scored from 0 (no ulceration) to 3 (severe ulceration). Results: After the initial 28 days of treatment, the decrease in ulcer severity was significantly greater after omeprazole treatment than after ranitidine treatment. Ulcer severity decreased significantly in group 3 horses after 14 days of treatment with omeprazole. Discontinuation of omeprazole resulted in worsening of ulcer scores; however, ulcer scores at completion of the study were less than at day 0. Horses that received omeprazole after 28 days of ranitidine treatment had a further reduction in ulcer severity. Conclusions: Omeprazole was more effective than ranitidine in healing gastric squamous ulcers in Thoroughbreds in race training. Improvement was detected by 14 days and persisted in most of the group 2 horses for at least 28 days after omeprazole treatment was discontinued.
Publication Date: 2005-11-30 PubMed ID: 16313043DOI: 10.2460/javma.2005.227.1636Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

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The study researched the comparative impact of omeprazole and ranitidine treatment on gastric squamous ulceration in racing Thoroughbreds, finding omeprazole to be more effective in healing such ulcers.

Study Design

  • The study was a modified crossover study which included 60 Thoroughbreds in race training with gastric squamous mucosal ulceration.
  • In the study, horses were randomly allocated into three groups. Each group received different treatments and had varying schedules over a total period of 56 days.
  • The first group had a 28-day period with no treatment, then they were administered omeprazole for 28 days. The second group received the omeprazole treatment first for 28 days, followed by no treatment for 28 days. The third group received ranitidine for 28 days, then they were administered omeprazole for 28 days.
  • Ulceration was observed and assessed via endoscopy at 4 periods: days 0, 28, 42, and 56, and ulcer scores from 0 (no ulceration) to 3 (severe ulceration) were assigned.

Findings

  • Omeprazole treatment over ranitidine treatment resulted in a significantly greater decrease in ulcer severity after the initial 28-day treatment.
  • Horses in the third group who switched from ranitidine to omeprazole treatment showed a significant decrease in ulcer severity after just 14 days of being treated with omeprazole.
  • While stopping omeprazole resulted in the worsening of ulcer scores, the scores at the conclusion of the study were still lower than those at day 0, indicating a net improvement over time.
  • Those horses that received omeprazole following 28 days of ranitidine treatment demonstrated a further reduction in ulcer severity.

Conclusions

  • Omeprazole proved more efficient than ranitidine in treating gastric squamous ulcers in racing Thoroughbreds.
  • Improvements were apparent within 14 days and were maintained in most of the horses in the second group for at least 28 days after discontinuing omeprazole treatment.

Cite This Article

APA
Lester GD, Smith RL, Robertson ID. (2005). Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. J Am Vet Med Assoc, 227(10), 1636-1639. https://doi.org/10.2460/javma.2005.227.1636

Publication

ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 227
Issue: 10
Pages: 1636-1639

Researcher Affiliations

Lester, Guy D
  • School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, Western Australia.
Smith, Rachael L
    Robertson, Ian D

      MeSH Terms

      • Administration, Oral
      • Animals
      • Anti-Ulcer Agents / administration & dosage
      • Anti-Ulcer Agents / therapeutic use
      • Cross-Over Studies
      • Female
      • Horse Diseases / drug therapy
      • Horse Diseases / pathology
      • Horses
      • Male
      • Omeprazole / administration & dosage
      • Omeprazole / therapeutic use
      • Physical Conditioning, Animal
      • Ranitidine / administration & dosage
      • Ranitidine / therapeutic use
      • Severity of Illness Index
      • Stomach Ulcer / drug therapy
      • Stomach Ulcer / pathology
      • Stomach Ulcer / veterinary
      • Time Factors
      • Treatment Outcome

      Citations

      This article has been cited 10 times.
      1. Vokes J, Lovett A, Sykes B. Equine Gastric Ulcer Syndrome: An Update on Current Knowledge.. Animals (Basel) 2023 Apr 5;13(7).
        doi: 10.3390/ani13071261pubmed: 37048517google scholar: lookup
      2. Hwang H, Dong HJ, Han J, Cho S, Kim Y, Lee I. Prevalence and treatment of gastric ulcers in Thoroughbred racehorses of Korea.. J Vet Sci 2022 Mar;23(2):e19.
        doi: 10.4142/jvs.21247pubmed: 35187877google scholar: lookup
      3. Hewetson M, Tallon R. Equine Squamous Gastric Disease: Prevalence, Impact and Management.. Vet Med (Auckl) 2021;12:381-399.
        doi: 10.2147/VMRR.S235258pubmed: 35004264google scholar: lookup
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      6. Banse HE, Andrews FM. Equine glandular gastric disease: prevalence, impact and management strategies.. Vet Med (Auckl) 2019;10:69-76.
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        doi: 10.1007/s40279-016-0563-4pubmed: 27282926google scholar: lookup
      8. Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses.. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
        doi: 10.1111/jvim.13578pubmed: 26340142google scholar: lookup
      9. Birkmann K, Junge HK, Maischberger E, Wehrli Eser M, Schwarzwald CC. Efficacy of omeprazole powder paste or enteric-coated formulation in healing of gastric ulcers in horses.. J Vet Intern Med 2014 May-Jun;28(3):925-33.
        doi: 10.1111/jvim.12341pubmed: 24628650google scholar: lookup
      10. Hellings IR, Larsen S. ImproWinu00ae in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.. Acta Vet Scand 2014 Mar 13;56(1):13.
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