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In vitro susceptibility of Pseudomonas mallei to antimicrobial agents.
Abstract: Pseudomonas mallei was isolated from pus samples obtained from 34 mallein-positive horses. The isolates were subjected to in vitro sensitivity test using 16 different antimicrobial discs. All isolates (34) were sensitive to sulfamethizole, gentamycin, tetracycline, sulfathiazole, kanamycin, tobramycin, streptomycin and a combination of trimethoprim and sulfamethoxazole while none of them were sensitive to cephalothin, colistin, ampicillin, penicillin and nitrofurantoin. Rifapicin, chloramphenicol and carbenicillin were effective against 32, 26 and 18 isolates respectively. The minimum inhibitory concentrations (MICs) of gentamycin, tetracycline, tobramycin, sulfamethizole, streptomycin, rifampicin and a combination of trimethoprim and sulfamethoxazole were 0.28, 0.38, 0.67, 1.40, 3.40, 5.86 and 5.30 micrograms/ml, respectively.
Publication Date: 1989-01-01 PubMed ID: 2776405DOI: 10.1016/0147-9571(89)90003-9Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This research article focuses on a study that investigated the sensitivity of a bacterium, Pseudomonas mallei, commonly found in horses, to various antimicrobial agents.
Overview of the Research
- The study was primarily conducted on 34 samples of Pseudomonas mallei, a bacterium isolated from pus samples obtained from horses testing positive for mallein.
- These bacterial isolates were subjected to a range of 16 different antibiotics in an in vitro (lab environment) susceptibility test.
Key Findings
- All the 34 bacterial isolates demonstrated sensitivity to eight types of antibiotics: sulfamethizole, gentamycin, tetracycline, sulfathiazole, kanamycin, tobramycin, streptomycin, and a combination of trimethoprim and sulfamethoxazole. This means these drugs were effective in inhibiting the growth of the bacterium.
- On the other hand, certain commonly used antibiotics such as cephalothin, colistin, ampicillin, penicillin, and nitrofurantoin showed no effect on this bacterium- the isolates were not sensitive to these antibiotics.
- Rifapicin, chloramphenicol, and carbenicillin were somewhat effective, showing activity against 32, 26, and 18 of the isolates respectively.
Minimum Inhibitory Concentrations (MICs)
- The study also calculated the minimum inhibitory concentrations (MICs) for seven of the effective antibiotics: gentamycin, tetracycline, tobramycin, sulfamethizole, streptomycin, rifampicin, and combination therapy of trimethoprim and sulfamethoxazole.
- MIC is the lowest concentration of an antibiotic that can prevent the growth of a bacterium. The lower the MIC, the more effective the antibiotic.
- The MICs for the tested antibiotics ranged from 0.28 to 5.86 micrograms/ml, indicating that not much of any of the effective antibiotics would be required to inhibit the growth of this particular strain of Pseudomonas mallei.
The findings of this research could be useful in selecting the most efficient antibiotic therapy for treating infections caused by Pseudomonas mallei in horses.
Cite This Article
APA
Al-Izzi SA, Al-Bassam LS.
(1989).
In vitro susceptibility of Pseudomonas mallei to antimicrobial agents.
Comp Immunol Microbiol Infect Dis, 12(1-2), 5-8.
https://doi.org/10.1016/0147-9571(89)90003-9 Publication
Researcher Affiliations
- Department of Medicine, College of Veterinary Medicine, Al-America, Baghdad, Iraq.
MeSH Terms
- Animals
- Anti-Bacterial Agents / pharmacology
- Drug Resistance, Microbial
- Gentamicins / pharmacology
- Glanders / microbiology
- Horses / microbiology
- Microbial Sensitivity Tests
- Pseudomonas / drug effects
Citations
This article has been cited 5 times.- Goodyear A, Strange L, Rholl DA, Silisouk J, Dance DAB, Schweizer HP, Dow S. An improved selective culture medium enhances the isolation of Burkholderia pseudomallei from contaminated specimens. Am J Trop Med Hyg 2013 Nov;89(5):973-982.
- Van Zandt KE, Greer MT, Gelhaus HC. Glanders: an overview of infection in humans. Orphanet J Rare Dis 2013 Sep 3;8:131.
- Estes DM, Dow SW, Schweizer HP, Torres AG. Present and future therapeutic strategies for melioidosis and glanders. Expert Rev Anti Infect Ther 2010 Mar;8(3):325-38.
- Heine HS, England MJ, Waag DM, Byrne WR. In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test. Antimicrob Agents Chemother 2001 Jul;45(7):2119-21.
- Kenny DJ, Russell P, Rogers D, Eley SM, Titball RW. In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob Agents Chemother 1999 Nov;43(11):2773-5.
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