Inbreeding, microsatellite heterozygosity, and morphological traits in Lipizzan horses.
Abstract: While the negative effects of inbreeding and reduced heterozygosity on fecundity and survival are well established, only a few investigations have been carried out concerning their influence on morphological traits. This topic is of particular interest for a small and closed population such as the Lipizzan horse. Thus, 27 morphological traits were measured in 360 Lipizzan mares and were regressed on the individual inbreeding coefficients, as well as on the individual heterozygosity and mean squared distances (mean d(2)) between microsatellite alleles within an individual. Both individual heterozygosity and mean d(2) were based on 17 microsatellite loci dispersed over 14 chromosomes. The results obtained by multivariate analysis reveal significant effects of stud (P <.0001), age at measurement (P <.0001), and mean d(2) (P =.0143). In univariate analyses, significant associations were obtained between length of pastern-hindlimbs and inbreeding coefficient (P <.01), length of cannons-hindlimb and mean d(2) (P <.01), and length of neck and mean d(2) (P <.001). After adjustment of single-test P values for multiple tests (Hochberg's step-up Bonferroni method), only the association of the length of neck and mean d(2) remained significant (P =.0213). Thus, no overall large effects of inbreeding, microsatellite heterozygosity, and mean d(2) on morphological traits were observed in the Lipizzan horse.
Publication Date: 2003-05-02 PubMed ID: 12721224DOI: 10.1093/jhered/esg029Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research explores the impact of inbreeding and reduced heterozygosity on the morphological traits of Lipizzan horses, a closed and small population. The study analyzed the correlations between these genetic factors and 27 physical attributes in 360 Lipizzan mares, however, found no considerable effects on the studied traits.
Research Methodology and Factors Analyzed
- The study revolves around Lipizzan horses, a closed population that can offer detailed insights into the effect of inbreeding and gene diversity on physical traits.
- A total of 27 morphological traits were measured in 360 Lipizzan mares.
- These values were then compared with the individual inbreeding coefficients of the horses, and individual heterozygosity and mean squared distances (mean d(2)) between their microsatellite alleles.
- The genetic data for heterozygosity and mean d(2) were obtained from 17 microsatellite loci distributed over 14 chromosomes.
Results and Observations
- The multivariate analysis indicated that the stud (the place where horses are kept and bred), the age at which the measurements were taken, and mean d(2) have substantial effects.
- In univariate analyses, significant correlations were found between the length of pastern-hindlimbs and inbreeding coefficient, the length of cannons-hindlimb and mean d(2), and length of the neck and mean d(2).
- However, when P values were adjusted for multiple tests using Hochberg’s step-up Bonferroni method, only the correlation between the length of the neck and mean d(2) remained significant.
Conclusion
- The conclusion of this study is that no substantial overall effects of inbreeding, microsatellite heterozygosity, and mean d(2) were found on the morphological traits studied in the Lipizzan horse population.
Cite This Article
APA
Curik I, Zechner P, Sölkner J, Achmann R, Bodo I, Dovc P, Kavar T, Marti E, Brem G.
(2003).
Inbreeding, microsatellite heterozygosity, and morphological traits in Lipizzan horses.
J Hered, 94(2), 125-132.
https://doi.org/10.1093/jhered/esg029 Publication
Researcher Affiliations
- Animal Science Department, Faculty of Agriculture University of Zagreb, Croatia. icurik@agr.hr
MeSH Terms
- Animals
- Body Constitution / genetics
- Genetic Markers
- Heterozygote
- Horses / anatomy & histology
- Horses / genetics
- Inbreeding
- Microsatellite Repeats
Citations
This article has been cited 13 times.- Klein R, Oláh J, Mihók S, Posta J. Pedigree-Based Description of Three Traditional Hungarian Horse Breeds.. Animals (Basel) 2022 Aug 14;12(16).
- Fu C, Ai Q, Cai L, Qiu F, Yao L, Wu H. Genetic Diversity and Population Dynamics of Leptobrachium leishanense (Anura: Megophryidae) as Determined by Tetranucleotide Microsatellite Markers Developed from Its Genome.. Animals (Basel) 2021 Dec 15;11(12).
- Doekes HP, Bijma P, Windig JJ. How Depressing Is Inbreeding? A Meta-Analysis of 30 Years of Research on the Effects of Inbreeding in Livestock.. Genes (Basel) 2021 Jun 18;12(6).
- Vostry L, Vostra-Vydrova H, Citek J, Gorjanc G, Curik I. Association of inbreeding and regional equine leucocyte antigen homozygosity with the prevalence of insect bite hypersensitivity in Old Kladruber horse.. Anim Genet 2021 Aug;52(4):422-430.
- Próchniak T, Kasperek K, Knaga S, Rozempolska-Rucińska I, Batkowska J, Drabik K, Ziȩba G. Pedigree Analysis of Warmblood Horses Participating in Competitions for Young Horses.. Front Genet 2021;12:658403.
- Kalashnikov V, Khrabrova L, Blohina N, Zaitcev A, Kalashnikova T. Dynamics of the Inbreeding Coefficient and Homozygosity in Thoroughbred Horses in Russia.. Animals (Basel) 2020 Jul 17;10(7).
- Giontella A, Sarti FM, Biggio GP, Giovannini S, Cherchi R, Pieramati C, Silvestrelli M. Genetic Parameters and Inbreeding Effect of Morphological Traits in Sardinian Anglo Arab Horse.. Animals (Basel) 2020 May 2;10(5).
- Comparini L, Podestà A, Russo C, Cecchi F. Effect of inbreeding on the "Club Foot" disorder in Arabian Pureblood horses reared in Italy.. Open Vet J 2019 Oct;9(3):273-280.
- Lewczuk D, Metera-Zarzycka E. Horse phenotyping based on video image analysis of jumping performance for conservation breeding.. PeerJ 2019;7:e7450.
- Ma H, Wang S, Zeng G, Guo J, Guo M, Dong X, Hua G, Liu Y, Wang M, Ling Y, Ding X, Zhao C, Wu C. The Origin of a Coastal Indigenous Horse Breed in China Revealed by Genome-Wide SNP Data.. Genes (Basel) 2019 Mar 21;10(3).
- Janova E, Futas J, Klumplerova M, Putnova L, Vrtkova I, Vyskocil M, Frolkova P, Horin P. Genetic diversity and conservation in a small endangered horse population.. J Appl Genet 2013 Aug;54(3):285-92.
- Bömcke E, Gengler N, Cothran EG. Genetic variability in the Skyros pony and its relationship with other Greek and foreign horse breeds.. Genet Mol Biol 2011 Jan;34(1):68-76.
- Lie HC, Simmons LW, Rhodes G. Does genetic diversity predict health in humans?. PLoS One 2009 Jul 27;4(7):e6391.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
