FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Vet J / Increased adenosine concentration in bronchoalveolar lavage ...
Veterinary journal (London, England : 1997)2011; 193(1); 268-270; doi: 10.1016/j.tvjl.2011.11.012

Increased adenosine concentration in bronchoalveolar lavage fluid of horses with lower airway inflammation.

Abstract: Several reports have suggested a role for adenosine in the pathogenesis of chronic airway conditions and this has led to new therapeutic strategies to limit airway inflammation. In this study, detectable levels of adenosine in bronchoalveolar lavage (BAL) samples from 11 horses with non-infectious lower-airway inflammation and 14 healthy controls are reported, with significantly higher values in horses with airway inflammation. Although these increased levels did not correlate with changes in neutrophil percentage in BAL, a positive association between adenosine levels and signs of lower airway inflammation (clinical score) was observed. These novel findings support the hypothesis that adenosine may contribute to bronchoconstriction and also act as a pro-inflammatory mediator in the bronchoalveolar milieu of horses with airway inflammation. Further investigation of this axis could lead to new approaches for the treatment of highly prevalent lower airway inflammatory conditions in the horse.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Get Full Text
Publication Date: 2011-12-27 PubMed ID: 22206730PubMed Central: PMC3832950DOI: 10.1016/j.tvjl.2011.11.012Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • N.I.H.
  • Extramural
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research illustrates a link between elevated adenosine levels in the bronchoalveolar lavage fluid of horses and lower airway inflammation, suggesting adenosine as a possible contributor to bronchoconstriction and a pro-inflammatory agent in horses.

Objective and Methodology

  • The study aimed to examine the adenosine levels in bronchoalveolar lavage (BAL) samples of horses. Samples were collected from 11 horses suffering from non-infectious lower airway inflammation and compared with 14 healthy controls.
  • The motivation behind this research is the emerging evidence highlighting adenosine as a possible contributor to chronic airway conditions.
  • Quantitative analyses were carried out to measure adenosine concentrations, and clinical scores were created to assess signs and severity of lower airway inflammation.

Findings and Interpretation

  • Results indicated significantly higher adenosine concentrations in the BAL samples of horses with airway inflammation. This indicates a possible role of adenosine in bronchoconstriction and lower airway inflammatory conditions.
  • No statistically significant link was found between the increased adenosine levels and changes in neutrophil percentage in the BAL samples.
  • However, a positive association was observed between adenosine concentrations and the clinical score, showing signs of lower airway inflammation.

Significance and Further Research

  • The study provides novel findings that adenosine could potentially act as a pro-inflammatory mediator in the bronchoalveolar milieu of horses. Horses with lower airway inflammation often experience bronchoconstriction, suggesting one of the potential instigators could be increased adenosine.
  • Understanding the role of adenosine in airway pathogenesis can support the development of novel therapeutic interventions against lower airway inflammation.
  • Your researchers suggest further investigation into this adenosine network, emphasizing the potential in developing new approaches to treating prevalent lower airway inflammatory conditions in horses.

Cite This Article

APA
Zhang L, Franchini M, Wehrli Eser M, Jackson EK, Dip R. (2011). Increased adenosine concentration in bronchoalveolar lavage fluid of horses with lower airway inflammation. Vet J, 193(1), 268-270. https://doi.org/10.1016/j.tvjl.2011.11.012

Publication

Veterinary journal (London, England : 1997)
ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 193
Issue: 1
Pages: 268-270

Researcher Affiliations

Zhang, Li
  • Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, CH-8057 Zurich, Switzerland.
Franchini, Marco
    Wehrli Eser, Meret
      Jackson, Edwin K
        Dip, Ramiro

          MeSH Terms

          • Adenosine / analysis
          • Animals
          • Bronchoalveolar Lavage / veterinary
          • Bronchoalveolar Lavage Fluid / cytology
          • Female
          • Horse Diseases / metabolism
          • Horses
          • Inflammation
          • Lung Diseases, Obstructive / metabolism
          • Lung Diseases, Obstructive / veterinary
          • Male
          • Respiratory System / immunology
          • Respiratory System / physiopathology

          Grant Funding

          • P30 DK079307 / NIDDK NIH HHS
          • DK079307 / NIDDK NIH HHS

          Conflict of Interest Statement

          . None of the authors of this paper has a financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of the paper.

          References

          This article includes 11 references
          1. Caruso M, Varani K, Tringali G, Polosa R. Adenosine and adenosine receptors: their contribution to airway inflammation and therapeutic potential in asthma.. Curr Med Chem 2009;16(29):3875-85.
            pubmed: 19747135doi: 10.2174/092986709789178055google scholar: lookup
          2. Couëtil LL, Hoffman AM, Hodgson J, Buechner-Maxwell V, Viel L, Wood JL, Lavoie JP. Inflammatory airway disease of horses.. J Vet Intern Med 2007 Mar-Apr;21(2):356-61.
            pubmed: 17427403doi: 10.1892/0891-6640(2007)21[356:iadoh]2.0.co;2google scholar: lookup
          3. Dip RG. Adenosine receptor modulation: potential implications in veterinary medicine.. Vet J 2009 Jan;179(1):38-49.
            pubmed: 17904398doi: 10.1016/j.tvjl.2007.08.005google scholar: lookup
          4. Driver AG, Kukoly CA, Ali S, Mustafa SJ. Adenosine in bronchoalveolar lavage fluid in asthma.. Am Rev Respir Dis 1993 Jul;148(1):91-7.
            pubmed: 8317821doi: 10.1164/ajrccm/148.1.91google scholar: lookup
          5. Hirt RA, Galler A, Shibly S, Bilek A. Airway hyperresponsiveness to adenosine 5'-monophosphate in feline chronic inflammatory lower airway disease.. Vet J 2011 Jan;187(1):54-9.
            pubmed: 19910226doi: 10.1016/j.tvjl.2009.10.007google scholar: lookup
          6. Huszár E, Vass G, Vizi E, Csoma Z, Barát E, Molnár Világos G, Herjavecz I, Horváth I. Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma.. Eur Respir J 2002 Dec;20(6):1393-8.
            pubmed: 12503694doi: 10.1183/09031936.02.00005002google scholar: lookup
          7. Kirschvink N, Fiévez L, Dogné S, Bureau F, Art T, Lekeux P. Comparison of inulin with urea as dilutional markers of bronchoalveolar lavage in healthy and heaves-affected horses.. Vet Res 2001 Mar-Apr;32(2):145-54.
            pubmed: 11361150doi: 10.1051/vetres:2001117google scholar: lookup
          8. Norris AA, Eyre P. Reactivity of equine tracheal smooth muscle to adenosine and some phosphorylated derivatives.. J Vet Pharmacol Ther 1982 Sep;5(3):199-201.
            pubmed: 6897267doi: 10.1111/j.1365-2885.1982.tb00432.xgoogle scholar: lookup
          9. Ren J, Mi Z, Jackson EK. Assessment of nerve stimulation-induced release of purines from mouse kidneys by tandem mass spectrometry.. J Pharmacol Exp Ther 2008 Jun;325(3):920-6.
            pubmed: 18322147doi: 10.1124/jpet.108.137752google scholar: lookup
          10. Tesarowski DB, Viel L, McDonell WN. Pulmonary function measurements during repeated environmental challenge of horses with recurrent airway obstruction (heaves).. Am J Vet Res 1996 Aug;57(8):1214-9.
            pubmed: 8836377
          11. Zhang L, Franchini M, Wehrli Eser M, Dip R. Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation.. Equine Vet J 2012 Jan;44(1):81-7.
            doi: 10.1111/j.2042-3306.2010.00350.xpubmed: 21496101google scholar: lookup

          Citations

          This article has been cited 0 times.
          Subscribe to our newsletter
          Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.