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Increased plasma fructosamine concentrations in laminitic horses.
Abstract: The use of plasma fructosamine concentration ([fructosamine]) as a marker of abnormal glucose homeostasis in laminitic horses has not been investigated. Objective: Plasma fructosamine concentration may be higher amongst laminitic horses than normal horses; this might relate to underlying insulin resistance. Objective: 1) To compare [fructosamine] between laminitic and normal horses. 2) To investigate associations between [fructosamine] at presentation in laminitic horses with a) single sample markers of insulin resistance and b) outcome. Methods: Plasma fructosamine concentration, fasting serum insulin concentration (insulin) and fasting plasma glucose concentration (glucose) were measured in 30 horses that presented with laminitis. Clinical details and follow-up data were recorded. Plasma fructosamine concentration was also measured in 19 nonlaminitic control horses. Results: Laminitic horses had significantly higher mean [fructosamine] than normal horses (P<0.001). Thirteen of 30 laminitic horses had fasting hyperinsulinaemia, 2/30 had fasting hyperglycaemia. Statistically significant univariable correlations were identified between [fructosamine] and [glucose], [insulin] and the proxies RISQI and MIRG. Trends for association between [fructosamine] and negative outcome did not reach statistical significance. Conclusions: Increased mean [fructosamine] in laminitic horses may represent abnormal glycaemic control and [fructosamine] may become a clinically useful marker.
© 2011 EVJ Ltd.
Publication Date: 2011-06-23 PubMed ID: 21696439DOI: 10.1111/j.2042-3306.2011.00419.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article investigates plasma fructosamine concentrations in horses with laminitis, a painful foot condition, and its potential as an indicator for abnormal glucose control. The study reveals that horses with laminitis have higher fructosamine concentrations than healthy horses, suggesting it could become a useful clinical marker.
Research Objectives
The research had two main objectives:
- To compare the concentration of plasma fructosamine between healthy horses and those suffering from laminitis.
- To investigate any possible relationships between the fructosamine levels in laminitic horses at the time of presentation and a) single sample markers of insulin resistance, and b) the eventual outcome or prognosis of the condition.
Methodology
The methods for this research were specifically detailed:
- Plasma fructosamine concentration, fasting serum insulin concentration, and fasting plasma glucose concentration were measured in 30 horses that were presented with laminitis.
- For comparison, the plasma fructosamine concentration was also measured in 19 horses that did not have laminitis (serving as control subjects).
- Additionally, the clinical details and follow-up data for each horse were recorded for further analysis.
Results
The results of the research showed:
- The mean plasma fructosamine concentration was significantly higher in the laminitic horses compared to the healthy horses.
- Out of 30 laminitic horses, 13 had fasting hyperinsulinaemia (an excess of insulin in the blood) and two had fasting hyperglycaemia (an excess of glucose in the blood).
- There were statistically significant correlations between the fructosamine levels and glucose levels, insulin levels, and the proxies for insulin resistance in the body of the horses (RISQI and MIRG).
Conclusion
Though any association between fructosamine levels and negative clinical outcomes wasn’t statistically significant, the research concludes that the increased mean plasma fructosamine concentration in laminitic horses may be indicative of abnormal glucose control. This could, in turn, suggest the potential application of plasma fructosamine as a clinically helpful marker for diagnosing and managing horses with laminitis.
Cite This Article
APA
Knowles EJ, Withers JM, Mair TS.
(2011).
Increased plasma fructosamine concentrations in laminitic horses.
Equine Vet J, 44(2), 226-229.
https://doi.org/10.1111/j.2042-3306.2011.00419.x Publication
Researcher Affiliations
- Bell Equine Veterinary Clinic, Mereworth, Maidstone, UK. e.j.knowles@gmail.com
MeSH Terms
- Animals
- Blood Glucose
- Case-Control Studies
- Female
- Foot Diseases / blood
- Foot Diseases / veterinary
- Fructosamine / blood
- Hoof and Claw
- Horse Diseases / blood
- Horses
- Inflammation / blood
- Inflammation / veterinary
- Insulin Resistance / physiology
- Male
Citations
This article has been cited 3 times.- Taylor S. A review of equine sepsis. Equine Vet Educ 2015 Feb;27(2):99-109.
- Ertelt A, Barton AK, Schmitz RR, Gehlen H. Metabolic syndrome: is equine disease comparable to what we know in humans?. Endocr Connect 2014 Sep;3(3):R81-93.
- Mlyneková E, Zaťko S, Halo M, Imrich I, Halo M Jr. The Effect of Seasonal Changes in Non-Structural Carbohydrates in Pasture on the Metabolic Profile of Horses with Laminitis. Animals (Basel) 2026 Jan 15;16(2).
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