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Tijdschrift voor diergeneeskunde1975; 100(4); 191-201;

[Indications for prostaglandins in the field of reproduction in farm animals (author’s transl)].

Abstract: Parenteral administration of 2.5-5 mg. of prostaglandin F2alpha to horses, 15 mg. to heifers or 25-30 mg to lactating cows and 15 mg. to sheep will induce regression of the corpus luteum (luteolysis) and a fertile oestrus within 48-72 hours. Because of their luteolytic effect prostaglandins may be used in various indications in the field of reproduction. An exception is the pig in which administration of prostaglandins does not induce luteolysis before D12 and therefore fails to induce oestrus. In horses, cattle and sheep, administration of prostaglandins during the first four days of the cycle is ineffective. In the present paper, a few indications for the use of prostaglandins are described, including induction of oestrus (in cases of suboestrus), synchronisation of oestrus, termination of unwanted gestation, elimination of a persistent corpus luteum (purulent endometritis, pyometra, mummified foetus), induction of parturition. In addition, some other indications are listed, such as reduction of the interval between parturition and conception, chronic endometritis, hydroallantois, luteinized cysts and suboestrus post weaning. In the opinion of the present authors, the most important field for the use of prostaglandins will be that of induction and synchronisation of oestrus. As regards the fertility of synchronized oestrus induced by prostaglandins, it is stated that, in cattle and horses, this is superior to that following treatment with progestagen. Extensive field trials will be required to determine whether the fertility of oestrus induced by prostaglandins is equivalent to that following spontaneous oestrus.
Publication Date: 1975-02-15 PubMed ID: 1171535
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Summary

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This research explores the implications of using prostaglandins in reproductive procedures for farm animals like horses, heifers, cows, and sheep. The study indicates that this biochemical can induce fertile oestrus and affect other reproduction-related factors.

Introduction to the Research

  • The study investigates the impact of using prostaglandins in the field of reproduction, particularly focusing on farm animals. It outlines how administering prostaglandin F2alpha can induce regression of the corpus luteum and make the animals fertile for reproductive activity.
  • Researchers have found that this prostaglandin F2alpha has an effect on horses, heifers, lactating cows, and sheep but it does not affect pigs in the same way.

Usage of Prostaglandins

  • Researchers discovered that administering prostaglandins is not effective during the first four days of the animal’s reproductive cycle.
  • Prostaglandins can be used for various reproduction-related procedures, such as inducing oestrus in cases of suboestrus, synchronizing oestrus, terminating unwanted gestation, and eliminating persistent corpus luteum.
  • They can also be used to stimulate parturition and manage conditions such as chronic endometritis, hydroallantois, luteinized cysts, and suboestrus post weaning.

Potential Advantages and Further Research

  • The authors suggest the key use of prostaglandins will be in the induction and synchronisation of oestrus for optimal breeding management. Such an application could potentially facilitate timed artificial insemination and improve pregnancy rates in farmed animals.
  • Compared to treatment with progestagen, the fertility of synchronized oestrus induced by prostaglandins was found to be superior in cattle and horses. Nevertheless, it is still unknown if the fertility following spontaneous oestrus matches that of oestrus induced by prostaglandins, hence the authors call for more extensive field trials.

Cite This Article

APA
Brand A, de Bois CH, Vandenhende R. (1975). [Indications for prostaglandins in the field of reproduction in farm animals (author’s transl)]. Tijdschr Diergeneeskd, 100(4), 191-201.

Publication

ISSN: 0040-7453
NlmUniqueID: 0031550
Country: Netherlands
Language: dut
Volume: 100
Issue: 4
Pages: 191-201

Researcher Affiliations

Brand, A
    de Bois, C H
      Vandenhende, R

        MeSH Terms

        • Animals
        • Cattle
        • Estrus / drug effects
        • Estrus Synchronization / drug effects
        • Female
        • Fertility / drug effects
        • Horses
        • Luteolysis / drug effects
        • Pregnancy
        • Prostaglandins F / pharmacology
        • Sheep