[Influence of atracurium on cardiovascular parameters in horses undergoing vitrectomy during general anaesthesia, and on recovery duration and quality].
Abstract: In most ocular procedures, a central position of the eye is necessary. This can be achieved using a deep plane of anaesthesia, locoregional blocks or with neuromuscular blocking agents. The aim of this study was to evaluate the influence of atracurium on cardiovascular parameters, and on recovery quality and duration in horses. Methods: Thirty-four warmblood horses undergoing in total 50 vitrectomies were divided into two groups. Premedication, induction and maintenance were identical in all patients. After 20 minutes, horses of group A received atracurium (0.1 mg/kg) while in the control group (group K) the depth of anaesthesia was adapted to keep the bulbus in a central position. Dobutamine and fluids were administered to maintain the mean arterial blood pressure (MAP) above 70 mmHg. Cardiac output (CO), heart rate (HR), MAP, respiratory rate, end-expiratory isoflurane concentration (ETIso) and dobutamine requirements were determined. Position and movement of the globe during the surgical procedure were scored. Time and quality of the recovery period was scored. Results: Horses of group K required significantly higher concentrations of isoflurane (group A: 1.08 ± 0.1%; group K: 1.34 ± 0.2%) and had an overall lower MAP (group A: 88.4 ± 10.3 mmHg; group K: 76.6 ± 11.6 mmHg) and CO (group A: 36.9 ± 11.7 l/min; group K: 28.5 ± 7.2 l/min) but needed significantly more dobutamine (group A: 0.37 ± 0.17 μg/kg/min; group K: 0.99 ± 0.46 μg/kg/min) compared to group A. Complete relaxation occurred 9.5 ± 2.5 minutes after atracurium bolus and lasted for 25 ± 7.1 minutes. The score of the bulbus position and movement was significantly lower in group A, resulting in a better quality for the surgical procedure. In group A, the recovery time to standing was significantly shorter (group A: 18.1 ± 5.4 min; group K: 31.5 ± 7.1 min), with no difference in quality. Conclusions: The use of atracurium resulted in a better cardiovascular condition, probably because of the isoflurane-sparing effect. The recovery time was shorter in these horses without negative effects on recovery quality. No signs of residual atracurium effects were detected.
Publication Date: 2013-12-12 PubMed ID: 24326792
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- Journal Article
- Randomized Controlled Trial
Summary
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The research study explores the impact of a neuromuscular blocking drug, atracurium, on the cardiovascular parameters of horses undergoing vitrectomy (eye surgery), and how it affects the recovery duration and quality. The study found that atracurium improved cardiovascular conditions in horses, reduced isoflurane requirement, and shortened recovery time, without any residual effects or drop in recovery quality.
Research Methodology
- The study included 34 warmblood horses that underwent a total of 50 vitrectomies.
- The patients were divided into two groups. The same premedication, induction, and maintenance methods were employed for all horses.
- 20 minutes in, Group A horses were administered atracurium (0.1mg/kg), while the depth of anaesthesia in the control group or Group K was adjusted to keep the eye in a central position.
- Dobutamine and fluids were given to maintain a mean arterial blood pressure (MAP) above 70mmHg.
- Various parameters including cardiac output (CO), heart rate (HR), MAP, respiratory rate, end-expiratory isoflurane concentration (ETIso), and dobutamine requirements were measured.
- The duration and quality of recovery were scored, as well as the position and movement of the eye during surgery.
Research Findings
- Horses in the control group required significantly higher isoflurane concentrations than the atracurium group.
- The control group also had an overall lower MAP and CO, but required significantly more dobutamine compared to the atracurium group.
- The atracurium group experienced complete relaxation approximately 9.5 minutes after the bolus and this lasted for around 25 minutes.
- The score for the eye’s position and movement was significantly lower in the atracurium group, resulting in a better quality for the surgical procedure.
- Recovery time to standing was significantly shorter in the atracurium group, with no difference in the quality of recovery.
Conclusions
- The usage of atracurium led to better cardiovascular conditions in horses, possibly due to the isoflurane-sparing effect.
- Recovery time post-surgery was shorter in the horses administered with atracurium, but this didn’t compromise the quality of recovery.
- No signs of lingering atracurium effects were detected.
Cite This Article
APA
Hopster K, Ohnesorge B, von Borstel M, Rohn K, Kästner S.
(2013).
[Influence of atracurium on cardiovascular parameters in horses undergoing vitrectomy during general anaesthesia, and on recovery duration and quality].
Tierarztl Prax Ausg G Grosstiere Nutztiere, 41(6), 371-377.
Publication
Researcher Affiliations
- Dr. Klaus Hopster, Klinik für Pferde, Stiftung Tierärztliche Hochschule Hannover, Bünteweg 9, 30559 Hannover, E-Mail: klaus.hopster@tiho-hannover.de.
MeSH Terms
- Anesthesia / adverse effects
- Anesthesia / methods
- Anesthesia / veterinary
- Anesthetics, Inhalation / administration & dosage
- Animals
- Atracurium / administration & dosage
- Atracurium / adverse effects
- Cardiovascular System / drug effects
- Eye Diseases / surgery
- Hemodynamics / drug effects
- Horse Diseases / surgery
- Horses
- Isoflurane / administration & dosage
- Neuromuscular Nondepolarizing Agents / administration & dosage
- Neuromuscular Nondepolarizing Agents / adverse effects
- Vitrectomy / methods
- Vitrectomy / veterinary
Citations
This article has been cited 3 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
- Tutunaru A, Dupont J, Gougnard A, Ida K, Serteyn D, Sandersen C. Retrospective evaluation of clinical use of cis-atracurium in horses.. PLoS One 2019;14(8):e0221196.
- Darlong V, Garg R, Pandey R, Khokhar S, Chandralekha, Sinha R, Punj J, Sinha R. Evaluation of minimal dose of atracurium for cataract surgery in children: A prospective randomized double-blind study.. Saudi J Anaesth 2015 Jul-Sep;9(3):283-8.
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