Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies.
Abstract: To investigate the influence of calcium chloride (CaCl(2)) on the cardio-respiratory effects of enoximone in isoflurane anaesthetized ponies. Methods: Prospective consecutive experimental trial. Animals Six healthy ponies, weighing 287 +/- 55 kg were included in this study. Methods: After sedation (romifidine, 80 microg kg(-1)), anaesthesia was induced with midazolam (0.06 mg kg(-1)) and ketamine (2.2 mg kg(-1)) and maintained with isoflurane in oxygen. The ponies' lungs were ventilated to maintain normocapnia. After 90 minutes, a bolus of enoximone (0.5 mg kg(-1)) was administered, followed by a CaCl(2) infusion (0.5 mg kg(-1) minute(-1) over 10 minutes) (treatment EC). Sodium, potassium, ionized and total calcium concentrations, cardiovascular variables and blood-gases were measured in the 120 minutes after treatment. Using a mixed model anova, the results were compared to those of a previous report [Vet Anaesth Analg, 34 (2007) 416], evaluating the effects of 0.5 mg kg(-1) enoximone in the same ponies and under identical circumstances (treatment E). Both an overall comparison and comparisons at specific time points after treatment were performed (alpha = 0.05). Results: Although ionized and total calcium concentrations were higher during treatment EC, the cardio-respiratory effects of enoximone were comparable for both treatments. A small but significant difference in packed cell volume was detected. Conclusions: Calcium chloride did not enhance the effects of enoximone in normocalcaemic anaesthetized ponies.
Publication Date: 2009-02-26 PubMed ID: 19239648DOI: 10.1111/j.1467-2995.2008.00435.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
Summary
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The research investigated whether calcium chloride affects the cardio-respiratory responses of enoximone in ponies sedated with isoflurane. It was discovered that calcium chloride did not enhance the effects of enoximone on these anaesthetized ponies.
Study Design and Methodology
- The study was a prospective experimental trial involving six healthy ponies, each weighing around 287 +/- 55 kg.
- After sedation with romifidine, anaesthesia was induced using midazolam and ketamine, and maintained with isoflurane in oxygen.
- The ponies’ lungs were ventilated to maintain normocapnia (a normal level of carbon dioxide in the blood).
Treatment Procedure and Measurement
- A bolus of enoximone was administered to each pony 90 minutes after sedation, followed by an infusion of calcium chloride over 10 minutes.
- After the treatment, several measurements were taken including sodium, potassium, ionized and total calcium concentrations, cardiovascular variables, and blood-gases. These measurements were taken in the 120 minutes following the treatment.
Data Analysis and Comparison
- The researchers performed a mixed model analysis of variance (ANOVA) on the collected data. Results were then compared to a previous report, which examined the effects of enoximone under similar conditions but without calcium chloride.
- Comparisons were made both overall and at specific time points after treatment.
Research Findings
- Despite greater ionized and total calcium concentrations in ponies treated with enoximone and calcium chloride, the cardio-respiratory effects of enoximone were similar for both treatments: those that did and didn’t include calcium chloride.
- The study found a small, notable difference in packed cell volume among the treated ponies.
Conclusion
- The findings showed that calcium chloride did not heighten the impact of enoximone in ponies anaesthetized with isoflurane. Therefore, it suggests no significant benefits in adding calcium chloride to the enoximone treatment regimen for anaesthetized ponies.
Cite This Article
APA
Schauvliege S, Van den Eede A, Duchateau L, Pille F, Vlaminck L, Gasthuys F.
(2009).
Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies.
Vet Anaesth Analg, 36(2), 101-109.
https://doi.org/10.1111/j.1467-2995.2008.00435.x Publication
Researcher Affiliations
- Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium. stijn.schauvliege@ugent.be
MeSH Terms
- Anesthesia / veterinary
- Anesthetics, Inhalation / pharmacology
- Animals
- Blood Gas Analysis / veterinary
- Blood Pressure / drug effects
- Body Temperature / drug effects
- Calcium / blood
- Calcium Chloride / pharmacology
- Cardiac Output
- Cardiotonic Agents / administration & dosage
- Cardiotonic Agents / pharmacology
- Enoximone / administration & dosage
- Enoximone / pharmacology
- Horses / physiology
- Isoflurane
- Oxygen / blood
- Potassium / blood
- Sodium / blood
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