Influence of dietary molybdenum on copper metabolism in ponies.
Abstract: The effects of molybdenum ingestion on copper metabolism were investigated in bile duct-cannulated ponies fed diets containing 1.01, 27.4 and 107.3 ppm molybdenum. Copper metabolism was assessed by examination of 64Cu and stable copper excretion in feces, bile and urine. The addition of molybdenum to the diet decreased copper absorption and retention as a consequence of increased excretion of dietary copper in feces and increased excretion of absorbed copper in bile. Only 5% or less of the absorbed copper was excreted in urine regardless of dietary treatment. Biliary molybdenum excretion was only 0.86 mg per 100 kg of body weight per day even when ponies were fed the highest level of molybdenum. However, increased molybdenum ingestion produced elevations in protein bound copper in bile. Molybdenum was absorbed by ponies but urinary excretion was effective in eliminating most of the element from the body.
Publication Date: 1981-01-01 PubMed ID: 7452378DOI: 10.1093/jn/111.1.96Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates how the consumption of molybdenum affects the way ponies process copper, revealing that a higher intake of molybdenum decreases copper absorption and increases its excretion through feces and bile.
Objective and Methodology
- The purpose of this study was to explore the interplay between dietary molybdenum, a chemical element, and copper metabolism in ponies.
- To do this, the researchers monitored ponies that were fed diets varying in molybdenum concentration (1.01, 27.4, and 107.3 ppm).
- Ponies’ copper metabolism was then assessed through analyzing copper excretion in feces, bile, and urine.
- In particular, the researchers focused on 64Cu, a radioactive isotope of copper, and stable copper, the naturally abundant, non-radioactive form of copper.
Findings
- The research found that increasing the ponies’ intake of molybdenum led to a decrease in copper absorption and retention in the body due to an increase in copper excreted in the feces and in the bile.
- Regardless of the concentration of molybdenum in the diet, only 5% or less of the absorbed copper was excreted through urine.
- Even with high molybdenum ingestion, biliary molybdenum excretion remained relatively low, with just 0.86 mg per 100 kg of body weight per day.
- Nonetheless, a rise in molybdenum intake corresponded to an increase in protein-bound copper levels in bile.
- Despite molybdenum being absorbed by ponies, its urinary excretion efficiently eliminated most of the element from the body.
Implications
- This research contributes to a better understanding of how different nutrients and elements interact within an organism’s system.
- The findings suggest a significant influence of molybdenum on copper metabolism and underline the necessity of careful dietary planning in domestic animals to ensure balanced nutrient intake.
- Furthermore, increased intake of molybdenum may be used as a strategy to control copper concentration in animals experiencing copper-related disorders.
Cite This Article
APA
Cymbaluk NF, Schryver HF, Hintz HF, Smith DF, Lowe JE.
(1981).
Influence of dietary molybdenum on copper metabolism in ponies.
J Nutr, 111(1), 96-106.
https://doi.org/10.1093/jn/111.1.96 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Bile / metabolism
- Bile Ducts
- Catheterization
- Ceruloplasmin / metabolism
- Copper / metabolism
- Copper / urine
- Digestion / drug effects
- Dose-Response Relationship, Drug
- Feces / analysis
- Horses / metabolism
- Molybdenum / blood
- Molybdenum / pharmacology
Citations
This article has been cited 1 times.- Dill SG, Hintz HF, deLahunta A, Waldron CH. Plasma and liver copper values in horses with equine degenerative myeloencephalopathy. Can J Vet Res 1989 Jan;53(1):29-32.
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