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Zentralblatt fur Veterinarmedizin. Reihe A1991; 38(7); 494-500; doi: 10.1111/j.1439-0442.1991.tb01040.x

Influence of dopamine and dobutamine on the cardiovascular depression during a standard halothane anaesthesia in dorsally recumbent, ventilated ponies.

Abstract: The influence of different rates of dopamine and dobutamine on the cardiovascular depression during a standard halothane anesthesia was studied in dorsally recumbent ventilated ponies. Haemodynamic and respiratory responses were investigated by means of cardiac output (CO) determination (thermodilution technique), mean systemic (MAP) and pulmonary artery pressure (MPAP) (direct intravascular method) and arterial blood analysis (blood gases and packed cell volume). An important cardiopulmonary depression characterized by decreases (55% of the standing values) in CO, cardiac index (CI), MAP, MPAP and other cardiovascular related parameters occurred in the dorsally recumbent anaesthetized ponies after a stabilization period of 30 minutes. Dopamine at 2 different infusion rates (2.5 and 5.0 micrograms/kg/min) induced few changes of the cardiopulmonary parameters (non-significant increases in MAP, CI, left ventricular work [LVW], stroke volume [SV]; non-significant decrease in total peripheral resistance [TPR]). Several minor time related influences were also observed (increases in MPAP and total pulmonary resistance [TpR]). Arterial blood gases did not change during the different dopamine infusions. Low doses of dobutamine (1.25 micrograms/kg/min) were efficient to counteract the cardiovascular depression. Significant increases in CO, CI, MAP, MPAP and SV were observed. TPR and TpR tended to decrease but non-significantly. Heart rate and blood gases remained constant. The higher doses of dobutamine (2.5 and 5.0 micrograms/kg/min) accentuated these changes but a significant increase in heart rate with even periods of severe tachycardia and an increase of the packed cell volume were also observed. Apparently, low doses of dobutamine were indicated for the management of the cardiovascular depression during anaesthesia in the dorsally recumbent ventilated horse.
Publication Date: 1991-08-01 PubMed ID: 1950240DOI: 10.1111/j.1439-0442.1991.tb01040.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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This research investigates the effects of dopamine and dobutamine on cardiovascular depression that occurs during standard halothane anesthesia in managed ventilated ponies. The results show that low doses of dobutamine are effective in counteracting the cardiovascular depression.

Research Methodology

  • The study was conducted in dorsally recumbent, ventilated ponies undergoing standard halothane anesthesia.
  • Cardiac output, mean systemic, and pulmonary artery pressure were assessed using thermodilution technique and direct intravascular method respectively.
  • Blood analysis was performed to examine blood gases and packed cell volume.

Findings: Stabilization Period

  • After a stabilization period of 30 minutes, the authors observed notable cardiopulmonary depression characterized by decreases in cardiac output, cardiac index, systemic and pulmonary artery pressure, and other cardiovascular parameters.

Impact of Dopamine

  • Dopamine was administered to the ponies at two different infusion rates (2.5 and 5.0 micrograms/kg/min). This induced minor changes of the cardiopulmonary parameters, with insignificant increases in systemic pressure, cardiac index, left ventricular work, stroke volume, and a trivial decrease in total peripheral resistance.
  • There were also a number of minor time-related changes observed, such as increases in pulmonary artery pressure and total pulmonary resistance.
  • The level of arterial blood gases remained constant during the different dopamine infusions.

Impact of Dobutamine

  • Low doses of dobutamine (1.25 micrograms/kg/min) were found to effectively combat the cardiovascular depression with significant increases in CO, CI, systemic and pulmonary artery pressure and stroke volume observed.
  • Total peripheral resistance and total pulmonary resistance tended to decrease, although not significantly. Heart rate and blood gases remained unchanged.
  • Higher doses of dobutamine (2.5 and 5.0 micrograms/kg/min) intensified these changes. However, along with those, a significant increase in heart rate and an increase of the packed cell volume were noticed. At times, periods of severe tachycardia (rapid heart rate) were also observed.

Conclusion

  • Based on the study’s observations, low doses of dobutamine could potentially be used to manage cardiovascular depression during anesthesia in the dorsally recumbent ventilated horse.

Cite This Article

APA
Gasthuys F, de Moor A, Parmentier D. (1991). Influence of dopamine and dobutamine on the cardiovascular depression during a standard halothane anaesthesia in dorsally recumbent, ventilated ponies. Zentralbl Veterinarmed A, 38(7), 494-500. https://doi.org/10.1111/j.1439-0442.1991.tb01040.x

Publication

ISSN: 0514-7158
NlmUniqueID: 0331323
Country: Germany
Language: English
Volume: 38
Issue: 7
Pages: 494-500

Researcher Affiliations

Gasthuys, F
  • Large Animal Surgical Clinic, State University of Gent, Belgium.
de Moor, A
    Parmentier, D

      MeSH Terms

      • Anesthesia / veterinary
      • Animals
      • Dobutamine / pharmacology
      • Dopamine / pharmacology
      • Female
      • Halothane
      • Hemodynamics / drug effects
      • Horses / physiology
      • Male

      Citations

      This article has been cited 1 times.
      1. Gorenberg EB, Slack J, Stefanovski D, Theiss D, Hopster K. Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane-anaesthetised horses. Equine Vet J 2025 Nov;57(6):1677-1689.
        doi: 10.1111/evj.14488pubmed: 40052197google scholar: lookup