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Home / Equine Research Bank / Vet Res Commun / Influence of fluid therapy on gentamicin pharmacokinetics in...
Veterinary research communications2005; 29(2); 141-147; doi: 10.1023/b:verc.0000047493.50112.97

Influence of fluid therapy on gentamicin pharmacokinetics in colic horses.

Abstract: The aminoglycoside antibiotic gentamicin is commonly used in equine medicine for the prevention and treatment of Gram-negative and staphylococcal bacteria in surgically treated colic patients. The pharmacokinetics of gentamicin in these patients might be altered by the disease status, and/or under the influence of fluid therapy. The purpose of this study was to investigate the effect of intravenous fluid treatment on gentamicin kinetics in colic patients. Colic patients subjected to laparotomy were given fluid infusions according to clinical status. Following gentamicin administration, blood samples were taken for gentamicin analysis at different time points, and the main pharmacokinetic parameters including Vc, Vss, t(1/2) and MRT were calculated. Horses undergoing fluid therapy showed a significantly different t(1/2), clearance and MRT as compared to non-infused patients. However, taking into account the clinical status of the patients receiving fluid support, the data suggest that endotoxaemia, rather than fluid therapy, influence gentamicin pharmacokinetics following laparotomy.
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Publication Date: 2005-02-26 PubMed ID: 15730138DOI: 10.1023/b:verc.0000047493.50112.97Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates how the administration of intravenous fluids in horses suffering from colic impacts the effectiveness of the antibiotic gentamicin. The study concluded that endotoxemia, a potential complication arising from colic surgery, rather than fluid therapy, seems to affect how gentamicin works in the patient’s body.

Objective of the Study

  • The study aimed to explore how intravenous fluid therapy affects the pharmacokinetics, or how the body absorbs, metabolizes and eliminates, of gentamicin in horses going through laparotomy for colic treatment.
  • Understanding this relationship is crucial in ensuring the effective administration and dose of gentamicin to this population of patients.

Methodology of the Study

  • The research was conducted on colic horses undergoing laparotomy, a surgical procedure to examine the abdominal region.
  • These horses were given intravenous fluid infusions based on their clinical status.
  • Gentamicin was administered following this, and blood samples were taken at various time intervals for gentamicin analysis.
  • The primary pharmacokinetic parameters including Vc (Volume of Central Compartment), Vss (Volume of Distribution at Steady State), t(1/2) (half-life), and MRT (Mean Residence Time) were then calculated.

Findings of the Study

  • The study found that horses receiving fluid therapy demonstrated significant changes in gentamicin’s half-life, clearance and MRT compared to those not given fluid infusions.
  • However, when considering the clinical status of the patients receiving the fluid support, the data indicates that endotoxaemia (the presence of endotoxins in the blood, which could be a complication from laparotomy), rather than the administered fluid therapy, might impact gentamicin pharmacokinetics.

Implications of the Study

  • This research suggests that clinicians should consider the patient’s endotoxin level in the blood, possibly from laparotomy complications, when assessing gentamicin dosage and response in equine patients undergoing fluid therapy.
  • Further research would be beneficial to confirm these findings and develop a comprehensive treatment guide for such patients.

Cite This Article

APA
van der Harst MR, Bull S, Laffont CM, Klein WR. (2005). Influence of fluid therapy on gentamicin pharmacokinetics in colic horses. Vet Res Commun, 29(2), 141-147. https://doi.org/10.1023/b:verc.0000047493.50112.97

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 29
Issue: 2
Pages: 141-147

Researcher Affiliations

van der Harst, M R
  • Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands. m.r.vanderHarst@vet.uu.nl
Bull, S
    Laffont, C M
      Klein, W R

        MeSH Terms

        • Animals
        • Anti-Bacterial Agents / pharmacokinetics
        • Colic / drug therapy
        • Colic / veterinary
        • Combined Modality Therapy / veterinary
        • Fluid Therapy / veterinary
        • Gentamicins / pharmacokinetics
        • Horse Diseases / metabolism
        • Horse Diseases / therapy
        • Horses
        • Time Factors

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        Citations

        This article has been cited 3 times.
        1. Ekstrand C, Nostell K, Gehring R, Bondesson U, Bröjer J. The disposition of trimethoprim and sulfadiazine in neonatal foals after intravenous administration. Vet Med Sci 2022 May;8(3):1065-1071.
          doi: 10.1002/vms3.763pubmed: 35152563google scholar: lookup
        2. Redpath A, Hallowell GD, Bowen IM. Use of aminoglycoside antibiotics in equine clinical practice; a questionnaire-based study of current use. Vet Med Sci 2021 Mar;7(2):279-288.
          doi: 10.1002/vms3.382pubmed: 33099884google scholar: lookup
        3. Rhodes DM, Magdesian KG, Byrne BA, Kass PH, Edman J, Spier SJ. Minimum inhibitory concentrations of equine Corynebacterium pseudotuberculosis isolates (1996-2012). J Vet Intern Med 2015 Jan;29(1):327-32.
          doi: 10.1111/jvim.12534pubmed: 25586790google scholar: lookup
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