Inhibitory effects of intravenous chloramphenicol sodium succinate on the disposition of phenylbutazone in horses.
Abstract: The effects of i.v. chloramphenicol sodium succinate on the pharmacokinetics of i.v. phenylbutazone in six healthy adult horses were investigated. Administration of chloramphenicol sodium succinate to mares reduced mean (+/- SD) phenylbutazone clearance from 0.600 +/- 0.222 to 0.339 +/- 0.123 ml/min per kg and increased mean (+/- SD) half life from 244 +/- 59.8 to 371 +/- 80.8 min and mean residence time from 333 +/- 86.2 to 533 +/- 124 min. The mean steady-state volume of distribution of phenylbutazone was unchanged, with mean (+/- SD) values of 187 +/- 28.9 ml/kg in control animals and 170 +/- 32.4 ml/kg after chloramphenicol sodium succinate.
Publication Date: 1985-10-01 PubMed ID: 3834064DOI: 10.1007/BF01059330Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research study investigates the effect of intravenous chloramphenicol sodium succinate on the pharmacokinetics of intravenous phenylbutazone in horses. The study revealed that chloramphenicol sodium succinate reduces the clearance of phenylbutazone, and increases its half-life and mean residence time.
Experiment Details
- The study was conducted on six healthy adult horses to explore the inhibitory effects of the antibiotic chloramphenicol sodium succinate on the pharmacokinetics (the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body) of phenylbutazone. Phenylbutazone is a medication often used in horses to manage pain and inflammation.
- Investigators measured several pharmacokinetic parameters such as phenylbutazone clearance, half-life, mean residence time, and the steady-state volume of distribution. These parameters give important insights into how the body processes and eliminates the drug.
Results
- Administration of chloramphenicol sodium succinate to mares resulted in a reduced phenylbutazone clearance from an average of 0.600 to 0.339 ml/min per kg. This shows that the presence of the antibiotic slows down the elimination of phenylbutazone from the body.
- The half-life (the time it takes for the concentration of the drug to decrease by half in the body) increased from 244 minutes to 371 minutes. This suggests that phenylbutazone stays in the body for a longer period when chloramphenicol sodium succinate is also present.
- Mean residence time (the average length of time that the drug molecule stays in the body) also increased from 333 to 533 minutes when chloramphenicol was administered.
- The steady-state volume of distribution which indicates the extent of drug distribution in the body, remained unchanged. It averaged 187 ml/kg in control animals and 170 ml/kg after administering chloramphenicol sodium succinate.
Conclusion
- The research concludes that chloramphenicol sodium succinate impacts the disposition of phenylbutazone in horses, reducing its clearance and extending its residence time in the body.
- This has potential clinical implications for the dosing and safety of phenylbutazone when used in combination with chloramphenicol sodium succinate in horses.
Cite This Article
APA
Gerken DF, Sams RA.
(1985).
Inhibitory effects of intravenous chloramphenicol sodium succinate on the disposition of phenylbutazone in horses.
J Pharmacokinet Biopharm, 13(5), 467-476.
https://doi.org/10.1007/BF01059330 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Biological Availability
- Chloramphenicol / administration & dosage
- Chloramphenicol / analogs & derivatives
- Chloramphenicol / blood
- Chloramphenicol / pharmacology
- Chromatography, High Pressure Liquid
- Dose-Response Relationship, Drug
- Female
- Horses / metabolism
- Injections, Intravenous
- Oxyphenbutazone / blood
- Phenylbutazone / administration & dosage
- Phenylbutazone / antagonists & inhibitors
- Phenylbutazone / blood
- Phenylbutazone / metabolism
- Phenylbutazone / pharmacology
- Time Factors
References
This article includes 15 references
- Pang KS, Gillette JR. Sequential first-pass elimination of a metabolite derived from a precursor.. J Pharmacokinet Biopharm 1979 Jun;7(3):275-90.
- Adams HR, Isaacson EL, Masters BS. Inhibition of hepatic microsomal enzymes by chloramphenicol.. J Pharmacol Exp Ther 1977 Nov;203(2):388-96.
- Finocchio EJ, Ozog FJ, Oehme FW, Johnson JH, Osbaldiston GW. Detection of phenylbutazone and oxyphenbutazone in the urine of thoroughbreds.. J Am Vet Med Assoc 1970 Feb 15;156(4):454-6.
- Azadegan A, Johnson DW, Stowe CM. Influence of time interval between administration of chloramphenicol and thiamylal on the sleeping time of mice.. Am J Vet Res 1980 Jun;41(6):976-7.
- Gupta RC, Welsch F, Thornburg JE, Paul BS. Effect of chloramphenicol pretreatment on malathion-induced acute toxicity in the rat.. J Toxicol Environ Health 1983 Apr-Jun;11(4-6):897-905.
- Adams HR, Dixit BN. Prolongation of pentobarbital anesthesia by chloramphenicol in dogs and cats.. J Am Vet Med Assoc 1970 Apr 1;156(7):902-5.
- Tobin T, Blake JW, Valentine R. Drug interactions in the horse: effects of chloramphenicol, quinidine, and oxyphenbutazone on phenylbutazone metabolism.. Am J Vet Res 1977 Jan;38(1):123-7.
- Adams HR. Prolongation of barbiturate anesthesia by chloramphenicol in laboratory animals.. J Am Vet Med Assoc 1970 Dec 1;157(11):1908-13.
- Brumbaugh GW, Martens RJ, Knight HD, Martin MT. Pharmacokinetics of chloramphenicol in the neonatal horse.. J Vet Pharmacol Ther 1983 Sep;6(3):219-27.
- Soma LR, Sams R, Duer W, Tobin T, Woodward C, McDonald J. Plasma and serum concentrations of phenylbutazone and oxyphenbutazone in racing Thoroughbreds 24 hours after treatment with various dosage regimens.. Am J Vet Res 1985 Apr;46(4):932-8.
- Sanders JE, Yeary RA, Fenner WR, Powers JD. Interaction of phenytoin with chloramphenicol or pentobarbital in the dog.. J Am Vet Med Assoc 1979 Jul 15;175(2):177-80.
- Koup JR, Gibaldi M, McNamara P, Hilligoss DM, Colburn WA, Bruck E. Interaction of chloramphenicol with phenytoin and phenobarbital. Case report.. Clin Pharmacol Ther 1978 Nov;24(5):571-5.
- Jähnchen E, Levy G. Inhibition of phenylbutazone elimination by its metabolite oxyphenbutazone.. Proc Soc Exp Biol Med 1972 Dec;141(3):963-5.
- DIXON RL, FOUTS JR. Inhibition of microsomal drug metabolic pathways by chloramphenicol.. Biochem Pharmacol 1962 Aug;11:715-20.
- Lam FC, Hung CT, Perrier DG. Estimation of variance for harmonic mean half-lives.. J Pharm Sci 1985 Feb;74(2):229-31.
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
