Intestinal ischemia-reperfusion injury in horses: pathogenesis and therapeutics.
Abstract: This article discusses the potential role of oxidative injury to the intestinal tract of horses and the therapeutic approaches that have been investigated to decrease cellular damage secondary to ischemia-reperfusion (IR) injury. Equine colic is a major concern for horse owners and veterinary practitioners. Strangulating and obstructive lesions of the small and large intestines commonly require intervention in patients via exploratory celiotomy. However, the application of information from experimentally induced IR injury in horses to clinical cases of naturally occurring equine colic is not clear. Thus, while the exact mechanisms and clinical significance of intestinal IR are being defined and may be matters of academic debate, a review of the available information may provide knowledge of potential underlying pathophysiologic mechanisms contributing to intestinal injury in equine colic. This information may allow clinicians to offer additional therapeutic strategies for horses with strangulating obstruction of the small or large intestine. Further clinical study of the therapeutic options for horses with naturally occurring disease is warranted.
Publication Date: 2012-09-01 PubMed ID: 22935993
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Summary
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The research investigates the role of oxidative damage in the horse’s digestive system, along with possible treatment methods focusing on reducing cellular harm caused by Ischemia-Reperfusion injury, a common issue associated with equine colic. The connection between this experimental data and real-life cases of equine colic, however, requires further study.
Ischemia-Reperfusion (IR) injury in horses
- The study revolves around Ischemia-Reperfusion (IR) injury in horses, a condition characterized by cellular damage due to blood flow problems, most commonly resulting from strangulation or obstruction in the intestines.
- This issue is a significant concern for horse owners and veterinary practitioners, often requiring surgical intervention (exploratory celiotomy) to address both small and large intestinal obstructions.
Oxidative Injury
- The paper highlights oxidative injury to the horse’s digestive system as a possible driving factor of the said IR injuries. Oxidative injury refers to cellular damage caused by harmful reactive oxygen species (ROS), leading to potential intestinal harm.
- Understanding the role of this oxidative injury in IR injuries could be beneficial to finding therapeutic methods to minimize the damage.
Therapeutic Approaches
- Various therapeutic strategies have been explored to decrease cellular damage due to IR injuries. However, the paper emphasizes the need to clarify the application of findings drawn from these experimental IR injury inductions to real-life cases of equine colic.
- While the precise mechanisms and the clinical significance of intestinal IR remain subjects of debate, the review of available information could offer useful knowledge of underlying pathophysiologic mechanisms contributing to intestinal injury in equine colic.
Necessity for Further Clinical Study
- Although the research offers valuable insights into possible pathophysiologic mechanisms leading to intestinal injury in equine colic, it calls for more clinical studies on therapeutic options for horses with a natural disease occurrence.
- Focused investigations will enhance understanding and likely lead to improved therapeutic strategies for horses suffering from both small and large intestine strangulating obstruction.
Cite This Article
APA
Wong DM, Moore RM, Brockus CW.
(2012).
Intestinal ischemia-reperfusion injury in horses: pathogenesis and therapeutics.
Compend Contin Educ Vet, 34(8), E5.
Publication
Researcher Affiliations
- Iowa State University, Ames, IA, USA.
MeSH Terms
- Animals
- Colic / complications
- Colic / surgery
- Colic / veterinary
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
- Ischemia / etiology
- Ischemia / pathology
- Ischemia / therapy
- Ischemia / veterinary
- Reperfusion Injury / etiology
- Reperfusion Injury / pathology
- Reperfusion Injury / therapy
- Reperfusion Injury / veterinary
Citations
This article has been cited 3 times.- Lambertini C, Bombardi C, Zannoni A, Bernardini C, Dondi F, Morini M, Rinnovati R, Spadari A, Romagnoli N. Proteinase Activated Receptor 4 in the Jejunum of Healthy Horses and of Horses With Epiploic Hernia. Front Vet Sci 2020;7:158.
- Morgaz J, Ventura S, Muñoz-Rascón P, Navarrete R, Pérez J, Granados MDM, Fernández-Sarmiento JA, Domínguez JM, Molina V, Gómez-Villamandos RJ, Zafra R. Assessment of effects of methylene blue on intestinal ischemia and reperfusion in a rabbit model: hemodynamic, histological and immunohistochemical study. BMC Vet Res 2020 Feb 12;16(1):54.
- Gonzalez LM, Fogle CA, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT. Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013. Equine Vet J 2015 May;47(3):279-84.
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