Intrafollicular effect of IGF1 on development of follicle dominance in mares.
Abstract: The effect of an injection of a supraphysiologic dose of rhIGF1 into the second-largest ovarian follicle (F2) at the expected beginning of deviation (F1, > or =20 mm; Day 0) on development of dominance by F2 was studied in mares (n=16; controls, n=8). F1 became dominant (> or =28 mm) in 8 of 8 and 15 of 16 follicles in the controls and treated groups, respectively. The incidence of dominance (P<0.001) and ovulation (P or =20mm after the expected beginning of deviation resulted in dominance by 8 of 12 follicles treated with rhIGF1 on Days 1-3 (n=8 mares). Results demonstrated that the IGF1 system plays a pivotal intrafollicular role in the deviation mechanism without altering systemic concentrations of the gonadotropins and ovarian follicular hormones.
Publication Date: 2007-11-22 PubMed ID: 18162334DOI: 10.1016/j.anireprosci.2007.11.007Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research explores the role of IGF1, a hormone-like substance, in influencing the development of ovarian follicle dominance in mares. Supraphysiologic doses of rhIGF1 were injected into the ovarian follicles, resulting in a markedly increased incidence of follicle dominance and ovulation.
Overview of the Study
- The researchers conducted an experiment on mares, focusing on the impact of Insulin-like growth factor 1 (IGF1) on the development of ovarian follicle dominance.
- They injected a supraphysiologic dose of rhIGF1, a recombinant human form of IGF1, into the second-largest ovarian follicle at the onset of follicular deviation.
- The size of the follicles was categorized using parameters such as F1, being more or equal to 20mm (which indicates the start of the deviation process), and dominance, being more or equal to 28mm.
Findings of the Study
- The outcome of the research showed that F1 became dominant in all control group follicles and almost all of the treated follicles.
- However, there was a notably greater incidence of F2 dominance and ovulation in the group that received the IGF1 treatment compared to the control group, indicating a significant influence of IGF1 on the development of follicle dominance.
- Despite the observed effect, the researchers found no significant effect on the systemic concentrations of several hormones, including Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), estradiol, or inhibin, following treatment.
Subsequent Experiment and Conclusion
- In an additional experiment, the researchers treated every follicle, except F1 when it reached more or equal to 20mm after the beginning of deviation. This treatment led to dominance in a majority of the follicles treated with rhIGF1.
- Overall, the research demonstrates the pivotal role of the IGF1 system in influencing intrafollicular deviation without altering systemic concentrations of various hormones. This suggests potential implications for understanding and possibly manipulating the process of ovarian follicle development and fertility in mares and potentially other species.
Cite This Article
APA
Ginther OJ, Gastal EL, Gastal MO, Beg MA.
(2007).
Intrafollicular effect of IGF1 on development of follicle dominance in mares.
Anim Reprod Sci, 105(3-4), 417-423.
https://doi.org/10.1016/j.anireprosci.2007.11.007 Publication
Researcher Affiliations
- Eutheria Foundation, Cross Plains, WI 53528, USA. ginther@svm.vetmed.wisc.edu
MeSH Terms
- Animals
- Estradiol / blood
- Female
- Follicle Stimulating Hormone / blood
- Horses / blood
- Horses / physiology
- Inhibins / blood
- Insulin-Like Growth Factor I / pharmacology
- Luteinizing Hormone / blood
- Ovarian Follicle / drug effects
- Ovarian Follicle / physiology
- Ovulation / drug effects
- Ovulation / physiology
- Statistics, Nonparametric
Citations
This article has been cited 4 times.- Gallelli MF, Bianchi C, Zampini E, Aba M, Gambarotta M, Miragaya M. Plasma IGF1 and 17β-Estradiol Concentrations During the Follicular Wave in Llamas. Front Vet Sci 2020;7:555261.
- Han Y, Wang S, Wang Y, Zeng S. IGF-1 Inhibits Apoptosis of Porcine Primary Granulosa Cell by Targeting Degradation of Bim(EL). Int J Mol Sci 2019 Oct 28;20(21).
- Wang T, Xue B, Shao H, Wang SY, Bai L, Yin CH, Zhao HY, Qi YC, Cui LL, He X, Ma YM. Effect of Dandelion Extracts on the Proliferation of Ovarian Granulosa Cells and Expression of Hormone Receptors. Chin Med J (Engl) 2018 Jul 20;131(14):1694-1701.
- Hatzirodos N, Hummitzsch K, Irving-Rodgers HF, Harland ML, Morris SE, Rodgers RJ. Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia. BMC Genomics 2014 Jan 18;15:40.
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