Intraperitoneal use of sodium carboxymethylcellulose in horses undergoing exploratory celiotomy.
Abstract: The effect of intraperitoneal sodium carboxymethylcellulose (SCMC) administration on clinical outcome and survival was evaluated in horses undergoing exploratory celiotomy for acute gastrointestinal disease. Comparison of variables was made retrospectively between 44 horses that had SCMC and 92 horses (controls) not treated with SCMC. Mean age, body weight, heart rate, packed cell volume and plasma total protein of horses at admission, and convalescent period were not significantly different between control and SCMC groups. No significant differences were noted between control horses and SCMC horses with respect to incisional infection, hernia formation, recurrent episodes of colic, clinical outcome, and long-term survival (> 6 months). Seventy-six (83%) control horses and 34 (77%) SCMC horses survived long-term. Seventy (76%) control horses and 30 (68%) SCMC horses survived without complications and returned to their previous use. These results suggest that intraperitoneal use of SCMC does not adversely affect abdominal incisional wound healing, clinical outcome or long-term survival, however, the efficacy of SCMC in prevention of postoperative intestinal adhesions in horses requires further investigation.
Publication Date: 1995-03-01 PubMed ID: 7778249DOI: 10.1111/j.1532-950x.1995.tb01304.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article investigates whether the use of sodium carboxymethylcellulose (SCMC) inside the abdomen influences the outcomes and survival rates of horses undergoing exploratory celiotomy for acute gastrointestinal disease. The study did not find significant differences between horses treated with SCMC and those that were not, suggesting that SCMC use doesn’t negatively impact wound healing, clinical results, or long-term survival.
Research Background
- The study was conducted to evaluate the impact of sodium carboxymethylcellulose (SCMC), used intraperitoneally (administered inside the abdominal cavity), on clinical outcomes and survival rates in horses undergoing exploratory celiotomy due to acute gastrointestinal disease.
Research Methodology
- A comparison was conducted retrospectively between a group of 44 horses treated with SCMC and a control group of 92 horses that did not receive the SCMC treatment.
- The researchers considered various factors for comparison, including mean age, body weight, heart rate, packed cell volume, plasma total protein levels at admission, and convalescent period. None of these factors showed significant differences between the control and SCMC groups.
Results of the Research
- The researchers found no significant differences between control horses and those treated with SCMC in terms of incisional infection, hernia formation, recurrent episodes of colic, clinical outcome, and long-term survival (more than 6 months).
- Long-term survival was observed in 76 (83%) of control horses and 34 (77%) of SCMC treated horses. Additionally, 70 (76%) of control horses and 30 (68%) of SCMC treated horses were found to have survived without complications and returned to their previous use.
Conclusions and Future Directions
- The results confirmed that the intraperitoneal use of SCMC does not adversely affect the healing of abdominal incisional wounds, clinical outcomes, or survival in the long term.
- However, the research article suggested the necessity of further investigations to evaluate the efficacy of SCMC in the prevention of postoperative intestinal adhesions in equine patients.
Cite This Article
APA
Mueller PO, Hunt RJ, Allen D, Parks AH, Hay WP.
(1995).
Intraperitoneal use of sodium carboxymethylcellulose in horses undergoing exploratory celiotomy.
Vet Surg, 24(2), 112-117.
https://doi.org/10.1111/j.1532-950x.1995.tb01304.x Publication
Researcher Affiliations
- Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
MeSH Terms
- Abdomen / surgery
- Acute Disease
- Animals
- Carboxymethylcellulose Sodium / administration & dosage
- Carboxymethylcellulose Sodium / pharmacology
- Carboxymethylcellulose Sodium / therapeutic use
- Female
- Follow-Up Studies
- Gastrointestinal Diseases / mortality
- Gastrointestinal Diseases / surgery
- Gastrointestinal Diseases / veterinary
- Horse Diseases / mortality
- Horse Diseases / prevention & control
- Horse Diseases / surgery
- Horses
- Injections, Intraperitoneal / veterinary
- Intestinal Diseases / prevention & control
- Intestinal Diseases / veterinary
- Male
- Peritoneal Cavity
- Prognosis
- Retrospective Studies
- Survival Analysis
- Tissue Adhesions / prevention & control
- Tissue Adhesions / veterinary
- Wound Healing / drug effects
Citations
This article has been cited 1 times.- Willette J, Guinn A, Munsterman A. Primary Jejunal Impactions Resolved via Exploratory Celiotomy in Six Horses: 2017-2023. Animals (Basel) 2025 Aug 12;15(16).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
