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Is the thoroughbred race-horse under chronic stress?

Abstract: Thoroughbred fillies were divided into three groups according to age: group 1, 7 fillies aged 1 to 2 years (G1) starting the training program; group 2, 9 fillies aged 2 to 3 years (G2) in a full training program; group 3, 8 older fillies 3 to 4 years of age (G3) training and racing. Blood samples were collected weekly from July to December. Cortisol was quantified using a solid phase DPC kit. The intra- and interassay coefficients of variation were 12.5% and 15.65% and sensitivity was 1.9 +/- 0.2 nmol/l. The semester average of cortisol levels varied between groups: G1 = 148.8 +/- 6.7, G2 = 125.7 +/- 5.8, G3 = 101.1 +/- 5.4 nmol/l, with G3 differing statistically from the other groups. The lower cortisol levels observed in the older fillies leads us to propose that the stress stimulus, when maintained over a long period of time, may become chronic and result in a reduction of hypophyseal corticotropin-releasing hormone receptors. The secretion of endogenous opioids may also lead to low serum cortisol levels.
Publication Date: 1998-03-13 PubMed ID: 9496444DOI: 10.1590/s0100-879x1997001000016Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The research aims to determine if thoroughbred racehorses, particularly young fillies, are under chronic stress, which is assessed through the analysis of cortisol levels in their blood.

Research Design and Methodology

  • For this study, the researchers divided thoroughbred fillies into three groups according to their age. Group 1 included seven fillies between 1 and 2 years old just starting their training program. Group 2 consisted of nine fillies aged 2 to 3 years, who were involved in an extensive training program. Group 3 composed of eight fillies from 3 to 4 years of age, both training and currently racing.
  • Blood samples were collected from all these horses weekly over a span from July to December.
  • These samples were analyzed for cortisol levels using a solid-phase DPC kit. Cortisol is a hormone released in response to stress and low blood glucose concentration.

Summary of Findings

  • The cortisol levels varied across the groups – The average cortisol levels for the semester in Group 1, Group 2, and Group 3 were 148.8 +/- 6.7, 125.7 +/- 5.8, and 101.1 +/- 5.4 nmol/l, respectively. This index indicates that Group 3, the older, racing fillies, had significantly lower cortisol levels than the others.
  • The researchers proposed that the stress stimulus, sustained over a long period, may become chronic for these horses and could result in a reduction of the receptors in the brain that respond to the corticotropin-releasing hormone from the pituitary gland. This could potentially explain the lower cortisol levels in the older fillies.
  • In addition to this, the researchers also suggested that the release of endogenous opioids, which are the body’s naturally occurring painkillers, could be another reason for the diminished serum cortisol levels.

Conclusion

  • The observed reduced cortisol levels in older fillies under chronic training and racing conditions suggest that these horses could indeed be in a state of chronic stress, which may pose concerns for their health and overall well-being.

Cite This Article

APA
Nogueira GP, Barnabe RC. (1998). Is the thoroughbred race-horse under chronic stress? Braz J Med Biol Res, 30(10), 1237-1239. https://doi.org/10.1590/s0100-879x1997001000016

Publication

ISSN: 0100-879X
NlmUniqueID: 8112917
Country: Brazil
Language: English
Volume: 30
Issue: 10
Pages: 1237-1239

Researcher Affiliations

Nogueira, G P
  • Departamento de Reprodução Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brasil. guilherme@infocenter.com.br
Barnabe, R C

    MeSH Terms

    • Animals
    • Chronic Disease
    • Horse Diseases / blood
    • Horses
    • Hydrocortisone / blood
    • Physical Conditioning, Animal
    • Stress, Physiological / blood
    • Stress, Physiological / veterinary

    Citations

    This article has been cited 6 times.
    1. Henshall C, Randle H, Francis N, Freire R. Habit Formation and the Effect of Repeated Stress Exposures on Cognitive Flexibility Learning in Horses. Animals (Basel) 2022 Oct 18;12(20).
      doi: 10.3390/ani12202818pubmed: 36290204google scholar: lookup
    2. Dzięgielewska A, Dunislawska A. Mitochondrial Dysfunctions and Potential Molecular Markers in Sport Horses. Int J Mol Sci 2022 Aug 4;23(15).
      doi: 10.3390/ijms23158655pubmed: 35955789google scholar: lookup
    3. Peterson EW, Segabinazzi LGTM, Gilbert RO, Bergfelt DR, French HM. Evaluation of Stress Accompanying Immunocontraceptive Vaccination in Donkeys. Animals (Basel) 2022 Feb 13;12(4).
      doi: 10.3390/ani12040457pubmed: 35203165google scholar: lookup
    4. Aldrich K, Velez-Irizarry D, Fenger C, Schott M, Valberg SJ. Pathways of calcium regulation, electron transport, and mitochondrial protein translation are molecular signatures of susceptibility to recurrent exertional rhabdomyolysis in Thoroughbred racehorses. PLoS One 2021;16(2):e0244556.
      doi: 10.1371/journal.pone.0244556pubmed: 33566847google scholar: lookup
    5. Pawluski J, Jego P, Henry S, Bruchet A, Palme R, Coste C, Hausberger M. Low plasma cortisol and fecal cortisol metabolite measures as indicators of compromised welfare in domestic horses (Equus caballus). PLoS One 2017;12(9):e0182257.
      doi: 10.1371/journal.pone.0182257pubmed: 28886020google scholar: lookup
    6. Kang OD, Lee WS. Changes in Salivary Cortisol Concentration in Horses during Different Types of Exercise. Asian-Australas J Anim Sci 2016 May;29(5):747-52.
      doi: 10.5713/ajas.16.0009pubmed: 26954193google scholar: lookup