Isolation of macrocyclic and non-macrocyclic trichothecenes (stachybotrys and fusarium toxins) from the Environment of 200 III Sport Horses.
Abstract: Satratoxins H and G, verrucarin J, and roridin E were isolated from the bedding straw of 200 sport horses exhibiting typical symptoms of stachybotryo-toxicosis. At the same time, the oat feed consumed by the horses contained non-macrocyclicFusarium trichothecenes: T-2 toxin and diacetoxyscirpenol.
Publication Date: 1987-09-01 PubMed ID: 23604940DOI: 10.1007/BF03191991Google Scholar: Lookup
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- Journal Article
Summary
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The study is about the isolation of harmful toxins (both macrocyclic and non-macrocyclic trichothecenes) from the environment of sport horses exhibiting symptoms of stachybotryo-toxicosis, particularly from their bedding straw and oat feed.
Understanding the Study
In this research, scientists investigated a health problem in sport horses. These horses were showing symptoms of a condition known as stachybotryo-toxicosis. The scientists suspected that the cause of this illness was exposure to specific toxins produced by a group of fungi. These toxins were believed to be present in the horse’s environment – specifically, in their bedding straw and oat feed.
- To confirm their hypothesis, they isolated the toxins from both the straw and feed.
- From the straw, they identified macrocyclic trichothecenes toxins – known as Satratoxins H and G, verrucarin J, and roridin E. These toxins are produced by the Stachybotrys fungus.
- From the oat feed, they identified non-macrocyclic trichothecenes toxins – specifically, T-2 toxin and diacetoxyscirpenol. These are produced by the Fusarium species of fungus.
Significance of the Findings
Macrocyclic and non-macrocyclic trichothecenes are a class of toxins produced by various fungi, which are known to cause serious health problems in animals and humans when ingested or inhaled.
- The identification of these toxins in the environment of sport horses is significant because this gives a probable cause for the illness observed in these animals.
- Knowing the source of the toxins, mitigation measures can be enacted to reduce or eliminate the fungi producing the toxins, thereby improving the health and performance of the horses.
Implications and Further Research
These findings suggest that other cases of ill health in horses and potentially other livestock could be linked to similar fungal toxins in their environments.
- Further research could focus on implementing and studying the effects of measures to reduce these toxins in animal environments.
- This may involve developing new ways of processing and storing feed, or investigating more resistant types of bedding material.
- There is also potential for studying the biology and ecology of these toxin-producing fungi further, to understand how to inhibit their growth and toxin production.
Cite This Article
APA
Harrach B, Bata A, Sándor G, Ványi A.
(1987).
Isolation of macrocyclic and non-macrocyclic trichothecenes (stachybotrys and fusarium toxins) from the Environment of 200 III Sport Horses.
Mycotoxin Res, 3(2), 65-68.
https://doi.org/10.1007/BF03191991 Publication
Researcher Affiliations
- Veterinary Medical Research Institute, Hungarian Academy of Sciences, POB 18, H-1581, Budapest, Hungary.
References
This article includes 7 references
- Harrach B, Nummi M, Niku-Paavola ML, Mirocha CJ, Palyusik M. Identification of "water-soluble" toxins produced by a Stachybotrys atra strain from Finland.. Appl Environ Microbiol 1982 Aug;44(2):494-5.
- Hajtós I, Harrach B, Szigeti G, Fodor L, Malik G, Varga J. Stachybotryotoxicosis as a predisposing factor of ovine systemic pasteurellosis.. Acta Vet Hung 1983;31(4):181-8.
- Boján F, Dankó G, Krasznai G. Immunological studies in experimental stachybotryotoxicosis.. Acta Vet Acad Sci Hung 1976;26(2):223-33.
- Harrach B, Bata A, Bajmócy E, Benko M. Isolation of satratoxins from the bedding straw of a sheep flock with fatal stachybotryotoxicosis.. Appl Environ Microbiol 1983 May;45(5):1419-22.
- Bata A, Harrach B, Ujszászi K, Kis-Tamás A, Lásztity R. Macrocyclic trichothecene toxins produced by Stachybotrys atra strains isolated in Middle Europe.. Appl Environ Microbiol 1985 Mar;49(3):678-81.
- Harrach B, Mirocha CJ, Pathre SV, Palyusik M. Macrocyclic trichothecene toxins produced by a strain of Stachybotrys atra from Hungary.. Appl Environ Microbiol 1981 Jun;41(6):1428-32.
- Jarvis BB, Lee YW, Cömezoglu SN, Yatawara CS. Trichothecenes produced by Stachybotrys atra from Eastern Europe.. Appl Environ Microbiol 1986 May;51(5):915-8.
Citations
This article has been cited 5 times.- Steinert K, Berg N, Kalinin DV, Jagels A, Würthwein EU, Humpf HU, Kalinina S. Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum.. ACS Omega 2022 Dec 13;7(49):45215-45230.
- Lindemann V, Jagels A, Behrens M, Hübner F, Humpf HU. In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys.. Toxins (Basel) 2022 Jun 8;14(6).
- Jagels A, Lindemann V, Ulrich S, Gottschalk C, Cramer B, Hübner F, Gareis M, Humpf HU. Exploring Secondary Metabolite Profiles of Stachybotrys spp. by LC-MS/MS.. Toxins (Basel) 2019 Feb 27;11(3).
- Harrach B. Method for small routine laboratories for the detection of satratoxins in straw samples.. Mycotoxin Res 1988 Mar;4(1):20-4.
- Kuhn DM, Ghannoum MA. Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective.. Clin Microbiol Rev 2003 Jan;16(1):144-72.
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