Joint report of the Third International Workshop on Lymphocyte Alloantigens of the Horse, Kennett Square, Pennsylvania, 25-27 April 1984.
Abstract: The Third International Workshop on Lymphocyte Alloantigens of the Horse was held on 25-27 April 1984 in Kennett Square, Pennsylvania. Twelve laboratories from five countries participated. The principal purpose of this Workshop was to determine the phenotypic and gene frequencies of the 10 equine lymphocyte antigens (ELA) and a non-ELA lymphocyte antigen, ELY-2.1, in several breeds of horse. A total of 86 alloantisera characterized in previous workshops were tested against lymphocytes from 1179 horses. In addition, several experimental antisera were also tested against the same panel of lymphocytes. As a result of analysis of these data, the Workshop recognized two new equine lymphocyte alloantigens: W11 of the ELA system, and ELY-1.1, an antigen not linked to the ELA system.
Publication Date: 1986-01-01 PubMed ID: 3826760DOI: 10.1111/j.1365-2052.1986.tb00730.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research from the Third International Workshop on Lymphocyte Alloantigens of the Horse involves collaborative testing and analysis to identify the frequencies of known equine lymphocyte antigens across different horse breeds and discover new ones.
Workshop Details
- The workshop was organized by international laboratories from five countries where they convened in Kennett Square, Pennsylvania, over the course of three days from 25-27 April 1984.
Workshop Purpose
- The primary goal of the workshop was to determine the phenotypic (observable traits) and gene frequencies of the ten identified equine lymphocyte antigens (ELA) and an additional non-ELA lymphocyte antigen, ELY-2.1, in various horse breeds.
- This study aimed to gather more information on how common these antigens are among horses, which could inform health and breeding decisions.
Methodology
- For this study, 86 alloantisera, antibodies used to identify and categorize antigens, characterized in previous workshops, were tested against lymphocytes from 1179 horses.
- To support this testing, several experimental antisera were also tested against the same panel of lymphocytes. This large scale cross-testing was designed to ensure the thoroughness of the results.
Findings
- Upon analyzing the result from the testing, the Workshop discovered two new equine lymphocyte alloantigens.
- The first one, W11, is part of the existing ELA system, suggesting a development or evolution within known antigen systems.
- The second antigen, ELY-1.1, is not linked to the ELA system providing evidence of the existence of separate, previously unidentified antigen systems in horses.
Cite This Article
APA
Antczak DF, Bailey E, Barger B, Guerin G, Lazary S, McClure J, Mottironi VD, Symons R, Templeton J, Varewyck H.
(1986).
Joint report of the Third International Workshop on Lymphocyte Alloantigens of the Horse, Kennett Square, Pennsylvania, 25-27 April 1984.
Anim Genet, 17(4), 363-373.
https://doi.org/10.1111/j.1365-2052.1986.tb00730.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Gene Frequency
- Histocompatibility Antigens
- Horses / immunology
- Isoantigens
- Lymphocytes / immunology
Citations
This article has been cited 12 times.- Sadeghi R, Moradi-Shahrbabak M, Miraei Ashtiani SR, Miller DC, Antczak DF. MHC haplotype diversity in Persian Arabian horses determined using polymorphic microsatellites. Immunogenetics 2018 May;70(5):305-315.
- Bergmann T, Lindvall M, Moore E, Moore E, Sidney J, Miller D, Tallmadge RL, Myers PT, Malaker SA, Shabanowitz J, Osterrieder N, Peters B, Hunt DF, Antczak DF, Sette A. Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses. Immunogenetics 2017 May;69(5):351-358.
- Miller D, Tallmadge RL, Binns M, Zhu B, Mohamoud YA, Ahmed A, Brooks SA, Antczak DF. Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes. Immunogenetics 2017 Mar;69(3):145-156.
- Bergmann T, Moore C, Sidney J, Miller D, Tallmadge R, Harman RM, Oseroff C, Wriston A, Shabanowitz J, Hunt DF, Osterrieder N, Peters B, Antczak DF, Sette A. The common equine class I molecule Eqca-1*00101 (ELA-A3.1) is characterized by narrow peptide binding and T cell epitope repertoires. Immunogenetics 2015 Nov;67(11-12):675-89.
- Schnabel LV, Pezzanite LM, Antczak DF, Felippe MJ, Fortier LA. Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro. Stem Cell Res Ther 2014 Jan 24;5(1):13.
- Tseng CT, Miller D, Cassano J, Bailey E, Antczak DF. Identification of equine major histocompatibility complex haplotypes using polymorphic microsatellites. Anim Genet 2010 Dec;41 Suppl 2(Suppl 2):150-3.
- Tallmadge RL, Campbell JA, Miller DC, Antczak DF. Analysis of MHC class I genes across horse MHC haplotypes. Immunogenetics 2010 Mar;62(3):159-72.
- Mealey RH, Zhang B, Leib SR, Littke MH, McGuire TC. Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus. Virology 2003 Sep 1;313(2):537-52.
- Mealey RH, Fraser DG, Oaks JL, Cantor GH, McGuire TC. Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: lessons for control of lentiviruses. Clin Immunol 2001 Nov;101(2):237-47.
- Hammond SA, Cook SJ, Lichtenstein DL, Issel CJ, Montelaro RC. Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process. J Virol 1997 May;71(5):3840-52.
- Allen G, Yeargan M, Costa LR, Cross R. Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1. J Virol 1995 Jan;69(1):606-12.
- Ansari HA, Hediger R, Fries R, Stranzinger G. Chromosomal localization of the major histocompatibility complex of the horse (ELA) by in situ hybridization. Immunogenetics 1988;28(5):362-4.
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