Keratitis due to Histoplasma spp. in a horse.

This research tracked the case of an eye infection in a horse, caused by the fungus Histoplasma. The study also found that a treatment involving a drug called fluconazole was effective.

Horse’s Condition

• The case involves a 5-year-old Holsteiner gelding from Germany with an observed white discoloration of the left cornea that had been noticeable for two months. The term Holsteiner gelding refers to the breed and sex of the horse, with Holsteiner being a German breed and gelding referring to a castrated male horse.

Cytologic Examination

• A cytologic examination was conducted which revealed the presence of both intra- and extracellular globular structures of up to 4 micro m in size.
• These structures consisted of a central spherical deeply basophilic body surrounded by an unstained halo.
• The structures were found to be morphologically consistent with Histoplasma spp, indicating that the horse was infected by this fungal organism.

Fungal Infection

• Histoplasma organisms are fungi that can cause infection in both humans and animals, commonly causing a disease called histoplasmosis.
• In Europe, where the horse was located, such infections are not endemic, making this case quite unusual.

Treatment

• The horse was given a topical application of fluconazole, an antifungal medication.
• This treatment was successful in eliminating the Histoplasma organisms within 10 days of initiation.

Conclusion

• In conclusion, this research provides valuable insight into an unusual case of a fungal eye infection in a horse caused by Histoplasma. It also demonstrates the effectiveness of fluconazole as a treatment option.