Laboratory measures of hemostasis and fibrinolysis after intravenous administration of epsilon-aminocaproic acid in clinically normal horses and ponies.
Abstract: To determine whether epsilon-aminocaproic acid (EACA) administered IV affects hemostasis and fibrinolysis in clinically normal horses and ponies. Methods: 20 clinically normal adult horses and ponies. Methods: Blood samples were collected 24 hours before (baseline) and 1 and 5 hours after i.v. administration of a low dose (30 mg/kg) or high dose (100 mg/kg) of EACA. Platelet count, fibrinogen concentration, prothrombin time, partial thromboplastin time (PTT), D-dimer concentration, alpha2-antiplasmin activity, and thrombin-antithrombin complex concentration were measured. Values at 1 and 5 hours were compared with baseline values. Results: hour after administration of a low dose of EACA, mean fibrinogen concentration was significantly lower than baseline concentration. Mean PTT was significantly shorter than the baseline value 5 hours after administration of a low dose of EACA. One hour after administration of 100 mg of EACA/kg, mean alpha2-antiplasmin activity was significantly higher than baseline activity. Mean fibrinogen concentration was significantly lower than baseline concentration 1 and 5 hours after administration of a high dose of EACA. Mean PTT was significantly shorter than the baseline value 5 hours after administration of a high dose of EACA. Conclusions: i.v. administration of 30 and 100mg of EACA/kg to clinically normal horses significantly modified some laboratory measures of hemostasis, consistent with its known antifibrinolytic effects. Although enhanced clot maintenance and diminished bleeding were not directly assessed, the clinical use of EACA may benefit some patients.
Publication Date: 2005-03-11 PubMed ID: 15757133DOI: 10.2460/ajvr.2005.66.313Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research explores how the intravenous administration of epsilon-aminocaproic acid (EACA) affects hemostasis and fibrinolysis in healthy horses and ponies, finding that it significantly alters some laboratory measurements related to clotting and breakdown of clots, implying potential beneficial uses in a clinical setting.
Study Objectives and Methodology
- The study aims to ascertain the effects of intravenous (IV) epsilon-aminocaproic acid (EACA) on stable hemostasis and fibrinolysis in horses and ponies.
- 20 clinically healthy adult horses and ponies were chosen for the study.
- Blood samples were collected 24 hours prior (as a baseline), and then 1 and 5 hours after the IV administration of a low dose (30 mg/kg) or a high dose (100 mg/kg) of EACA.
- Several components and measures of blood clotting, including platelet count, fibrinogen concentration, prothrombin time, partial thromboplastin time (PTT), D-dimer concentration, alpha2-antiplasmin activity, and thrombin-antithrombin complex concentration were analyzed.
- Findings at the 1-and 5-hour marks were compared to the baseline data.
Results of the Study
- Intake of a low dose of EACA resulted in a significant decrease in the average fibrinogen concentration one hour after administration, compared to the baseline level.
- Mean PTT was notably shorter five hours after the administration of a low dose of EACA than the baseline value.
- Alpha2-antiplasmin activity was significantly higher one hour after a 100mg/kg dosage of EACA, compared to the baseline activity.
- A high dose of EACA caused a significant decrease in the fibrinogen concentration both one and five hours after administration, compared to the baseline concentration.
- PTT was significantly reduced five hours after a high EACA dose compared to the baseline value.
Conclusions from the Study
- Administering 30mg and 100mg doses of EACA to healthy horses through IV significantly alters some laboratory measures of hemostasis. This finding aligns with EACA’s known effects as an antifibrinolytic agent.
- Despite not directly assessing enhanced clot maintenance and diminished bleeding, this study implies that the use of EACA could potentially benefit certain patients clinically.
Cite This Article
APA
Heidmann P, Tornquist SJ, Qu A, Cebra CK.
(2005).
Laboratory measures of hemostasis and fibrinolysis after intravenous administration of epsilon-aminocaproic acid in clinically normal horses and ponies.
Am J Vet Res, 66(2), 313-318.
https://doi.org/10.2460/ajvr.2005.66.313 Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331-4803, USA.
MeSH Terms
- Aminocaproic Acid / administration & dosage
- Animals
- Antithrombin III
- Female
- Fibrin Fibrinogen Degradation Products / analysis
- Fibrinogen / analysis
- Fibrinolysis / drug effects
- Fibrinolysis / physiology
- Hemostasis / physiology
- Horses / physiology
- Infusions, Intravenous / veterinary
- Male
- Partial Thromboplastin Time / veterinary
- Peptide Hydrolases / blood
- Platelet Count / veterinary
- Prothrombin Time / veterinary
- alpha-2-Antiplasmin / analysis
Citations
This article has been cited 1 times.- Poole DC, Erickson HH. Exercise-induced pulmonary hemorrhage: where are we now?. Vet Med (Auckl) 2016;7:133-148.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
