Lack of systemic absorption of lidocaine from 5% patches placed on horses.
Abstract: To measure concentrations of lidocaine serum after application of two 5% patches on horses. Methods: Prospective experimental trial Methods: Six client-owned, systemically healthy horses. Methods: The hair was clipped on the medial aspect above the carpus of both fore limbs and 2 patches of 5% lidocaine were applied within 30 minutes of jugular catheter placement and the area was then bandaged. Venous blood was drawn from a jugular vein catheter that was inserted using lidocaine as a local block. Samples were drawn immediately before and at 2, 4, 6, 8, and 12 hours after patch application. The presence of lidocaine in serum was determined using an ELISA test. Results: Lidocaine was detected in the serum of three horses at 0 hours immediately following the local block for catheter placement. Lidocaine was not detected at any other time from 2 to 12 hours. There was mild erythema at the site of patch placement at 12 hours in one horse but this resolved within 1 hour of patch removal. There were no other apparent adverse effects from the patches on any other horse. Conclusions: Five percent lidocaine patches applied proximally to the carpus did not result in detectable systemic concentrations of lidocaine. Conclusions: Any analgesic effects that might be produced by application of 5% lidocaine patches on horses will not be due to systemic absorption of the drug.
Publication Date: 2007-08-13 PubMed ID: 17696971DOI: 10.1111/j.1467-2995.2007.00348.xGoogle Scholar: Lookup
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- Journal Article
- Adverse Effects
- Bandaging
- Blood Analysis
- Clinical Pathology
- Clinical Study
- Drug
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Equine Health
- Experimental Methods
- Horses
- Lidocaine
- Local Anaesthesia
- Pharmacodynamics
- Pharmacokinetics
- Serum
- Topical Administration
- Veterinary Medicine
- Veterinary Practice
- Veterinary Procedure
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research study evaluated the absorption levels of lidocaine in horses when applied via a 5% lidocaine patch and found no systemic absorption of the drug, suggesting that any pain-relief effects are not due to the drug entering the bloodstream.
Study Overview
The study aimed to investigate whether or not a 5% lidocaine patch applied to horses results in the medication being absorbed into the bloodstream of the horse. The researchers used a sample of six healthy horses for the experimental trial.
Methods
- The team initiated the experiment by grooming the horses, clipping the hair on a specific part of their forelimbs, and applying two patches of 5% lidocaine. The patches were applied within 30 minutes of establishing a jugular catheter.
- Blood samples were collected from a catheter inserted into a jugular vein. The area for catheter insertion was temporarily numbed with lidocaine to reduce any discomfort.
- Blood samples were collected immediately before patch application and then at regular intervals for up to 12 hours afterwards – at 2, 4, 6, 8, and 12 hours post-applications.
- The collected blood samples underwent an ELISA test to detect the presence of lidocaine in the bloodstream.
Results
- The results showed that traces of lidocaine were found in the bloodstream of three horses immediately after the local numbing for catheter placement, as expected.
- However, no traces of lidocaine were detected in any of the horses’ bloodstream at all subsequent sampling times up to 12 hours after patch application.
- Only minor side effects were observed, with one instance of mild skin redness at the patch site that resolved within an hour of patch removal.
Conclusions
- The researchers concluded that the administration of a 5% lidocaine patch on horses does not seem to result in the absorption of the drug into the systemic circulation.
- This information implies that any potential pain-relieving effects from the application of lidocaine patches are not due to the systemic absorption of the drug into the horse’s body but likely due to localized numbing where the patch was applied.
Cite This Article
APA
Bidwell LA, Wilson DV, Caron JP.
(2007).
Lack of systemic absorption of lidocaine from 5% patches placed on horses.
Vet Anaesth Analg, 34(6), 443-446.
https://doi.org/10.1111/j.1467-2995.2007.00348.x Publication
Researcher Affiliations
- Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA. lbidwell@roodandriddle.com
MeSH Terms
- Administration, Cutaneous
- Anesthetics, Local / administration & dosage
- Anesthetics, Local / blood
- Anesthetics, Local / pharmacokinetics
- Animals
- Horses / metabolism
- Lidocaine / administration & dosage
- Lidocaine / blood
- Lidocaine / pharmacokinetics
- Prospective Studies
- Skin Absorption
Citations
This article has been cited 1 times.- Stahl J, Kietzmann M. The effects of chemical and physical penetration enhancers on the percutaneous permeation of lidocaine through equine skin.. BMC Vet Res 2014 Jun 20;10:138.
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