Large Animal Models for Osteochondral Regeneration.
Abstract: Namely, in the last two decades, large animal models - small ruminants (sheep and goats), pigs, dogs and horses - have been used to study the physiopathology and to develop new therapeutic procedures to treat human clinical osteoarthritis. For that purpose, cartilage and/or osteochondral defects are generally performed in the stifle joint of selected large animal models at the condylar and trochlear femoral areas where spontaneous regeneration should be excluded. Experimental animal care and protection legislation and guideline documents of the US Food and Drug Administration, the American Society for Testing and Materials and the International Cartilage Repair Society should be followed, and also the specificities of the animal species used for these studies must be taken into account, such as the cartilage thickness of the selected defect localization, the defined cartilage critical size defect and the joint anatomy in view of the post-operative techniques to be performed to evaluate the chondral/osteochondral repair. In particular, in the articular cartilage regeneration and repair studies with animal models, the subchondral bone plate should always be taken into consideration. Pilot studies for chondral and osteochondral bone tissue engineering could apply short observational periods for evaluation of the cartilage regeneration up to 12 weeks post-operatively, but generally a 6- to 12-month follow-up period is used for these types of studies.
Publication Date: 2018-05-08 PubMed ID: 29736586DOI: 10.1007/978-3-319-76735-2_20Google Scholar: Lookup
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Summary
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The research article focuses on how large animal models – including sheep, goats, pigs, dogs, and horses – have been used for the past two decades to study the development and treatment of human osteoarthritis.
Use of Large Animal Models in Osteoarthritis Research
- The paper discusses how large animal models, specifically sheep, goats, pigs, dogs, and horses, are utilized in the study of osteoarthritis, specifically in understanding the disease’s physiopathology and in the development of new treatments for the human version of the illness.
- Cartilage and/or osteochondral defects are generally studied in these models at the stifle joint, with specific focus on the condylar and trochlear femoral areas, sites where natural regeneration is not seen.
- These animal studies also strictly abide by the guidelines set out by the US Food and Drug Administration, the American Society for Testing and Materials, and the International Cartilage Repair Society, ensuring the welfare of the animals.
- The unique characteristics of the animal species, such as the thickness of the cartilage at the chosen site of the defect, the size of the critical cartilage defect, and the anatomy of the joint are taken into account in these studies, as they influence the post-operative techniques used to evaluate the repair of the chondral/osteochondral area.
Understanding the Roles of the Subchondral Bone Plate and Post-Operative Techniques
- In studies centered on the regeneration and repair of the articular cartilage, special consideration is given to the subchondral bone plate. This bone plays a significant role in the function and maintenance of the cartilage and hence, its importance in these studies.
- Experimental studies for chondral and bone tissue engineering generally employ short observational periods for evaluation of the cartilage regeneration, lasting up to 12 weeks post-operatively. However, for most types of these studies, the typical follow-up period is between 6 and 12 months, providing a more comprehensive overview of the regeneration process and the effectiveness of the treatments or procedures employed.
Cite This Article
APA
Dias IR, Viegas CA, Carvalho PP.
(2018).
Large Animal Models for Osteochondral Regeneration.
Adv Exp Med Biol, 1059, 441-501.
https://doi.org/10.1007/978-3-319-76735-2_20 Publication
Researcher Affiliations
- Department of Veterinary Sciences, Agricultural and Veterinary Sciences School, University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal. idias@utad.pt.
- 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque da Ciência e Tecnologia, Zona Industrial da Gandra, Barco - Guimarães, 4805-017, Portugal. idias@utad.pt.
- Department of Veterinary Medicine, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. idias@utad.pt.
- Department of Veterinary Sciences, Agricultural and Veterinary Sciences School, University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal.
- 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque da Ciência e Tecnologia, Zona Industrial da Gandra, Barco - Guimarães, 4805-017, Portugal.
- Department of Veterinary Medicine, ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
- Department of Veterinary Medicine, University School Vasco da Gama, Av. José R. Sousa Fernandes 197, Lordemão, Coimbra, 3020-210, Portugal.
- CIVG - Vasco da Gama Research Center, University School Vasco da Gama, Coimbra, Portugal.
MeSH Terms
- Animals
- Biocompatible Materials / therapeutic use
- Bone Diseases / surgery
- Bone Diseases / therapy
- Cartilage Diseases / surgery
- Cartilage Diseases / therapy
- Chondrocytes / transplantation
- Dogs
- Goats
- Horses
- Humans
- Implants, Experimental
- Materials Testing / methods
- Models, Animal
- Sheep
- Species Specificity
- Stem Cell Transplantation
- Swine
- Swine, Miniature
- Tissue Engineering / methods
- Tissue Scaffolds
Citations
This article has been cited 16 times.- Jiang H, Lu J, Li J, Liu Z, Chen F, Wu R, Xu X, Liu Y, Jiang Y, Shi D. A novel allogeneic acellular matrix scaffold for porcine cartilage regeneration.. BMC Biotechnol 2023 Sep 14;23(1):38.
- Wang Y, Chen Y, Wei Y. Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration.. Biomater Transl 2022;3(4):264-279.
- Barui S, Ghosh D, Laurencin CT. Osteochondral regenerative engineering: challenges, state-of-the-art and translational perspectives.. Regen Biomater 2023;10:rbac109.
- Hart DA. Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies.. Int J Mol Sci 2022 Dec 6;23(23).
- Ma Z, Wang Y, Xue Y, Zhang W, Li D, Li Y, Li G, Zhou H, Hu X, Deng T, Hu K. Traumatic temporomandibular joint bony ankylosis in growing rats.. BMC Oral Health 2022 Dec 9;22(1):585.
- Fugazzola MC, Wever KE, van de Lest C, de Grauw J, Salvatori D. Reporting of anaesthesia and pain management in preclinical large animal models of articular cartilage repair - A long way to go.. Osteoarthr Cartil Open 2022 Jun;4(2):100261.
- Dias IE, Viegas CA, Requicha JF, Saavedra MJ, Azevedo JM, Carvalho PP, Dias IR. Mesenchymal Stem Cell Studies in the Goat Model for Biomedical Research-A Review of the Scientific Literature.. Biology (Basel) 2022 Aug 27;11(9).
- Lesage C, Lafont M, Guihard P, Weiss P, Guicheux J, Delplace V. Material-Assisted Strategies for Osteochondral Defect Repair.. Adv Sci (Weinh) 2022 May;9(16):e2200050.
- Peng L, Zhang B, Luo X, Huang B, Zhou J, Jiang S, Guo W, Tian G, Tian Z, Shen S, Li Y, Sui X, Liu S, Guo Q, Li H. Small Ruminant Models for Articular Cartilage Regeneration by Scaffold-Based Tissue Engineering.. Stem Cells Int 2021;2021:5590479.
- Aarntzen EHJG, Noriega-Álvarez E, Artiko V, Dias AH, Gheysens O, Glaudemans AWJM, Lauri C, Treglia G, van den Wyngaert T, van Leeuwen FWB, Terry SYA. EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases.. EJNMMI Res 2021 Sep 6;11(1):85.
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- Papantoniou I, Nilsson Hall G, Loverdou N, Lesage R, Herpelinck T, Mendes L, Geris L. Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.. Adv Drug Deliv Rev 2021 Feb;169:22-39.
- Meng X, Ziadlou R, Grad S, Alini M, Wen C, Lai Y, Qin L, Zhao Y, Wang X. Animal Models of Osteochondral Defect for Testing Biomaterials.. Biochem Res Int 2020;2020:9659412.
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