Lasalocid toxicosis is inadequately quantified for horses.

The research article assesses the toxicity of Lasalocid in horses. It questions the current estimate of LD50 (the lethal dose at which 50% of the population would die) based on discrepancies in the analyzed data.

Raw Data Analysis

The researchers pointed out inconsistent data analysis in estimating the LD50 for Lasalocid in horses. From the paper, we understand that:

• The existing estimate of LD50, 21.5 mg/kg body weight (BW), was drawn only from data on 4 horses that died after being administered respective doses of 15, 21, 22, and 26 mg/kg of Lasalocid.
• This existing analysis completely ignored the survival data from an additional 6 horses that were given varying dose levels ranging from 5, 10, 14, 18, 19, 25, 29, and 50 mg/kg and survived.
• Consequently, this existing LD50 estimate was deemed flawed and biased due to its selective data extraction.

Insufficient Data

Upon inspection of all the available data, several observations were made:

• There was inadequate data to accurately determine the LD50 of Lasalocid in horses.
• However, the comprehensive dataset suggested the lowest toxic dose at 15 mg/kg.
• This suggestion was based on a single affected animal in 8 tests that were undertaken with escalating lasalocid dosages ranging from 5 to 15 mg/kg.
• The verification of this new finding was difficult due to the lack of balance in the experiment’s design – implying that a more evidence-based conclusion requires additional investigation and testing.