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Journal of equine veterinary science2025; 155; 105713; doi: 10.1016/j.jevs.2025.105713

Lethal Sycamore maple intoxication in a grazing three-month-old foal.

Abstract: The case of a young foal poisoned by maple toxin is described. It showed signs of myopathy caused by ingesting life-threatening amounts of maple toxin. Some maple trees (Acer species) can pose a health risk to grazing horses. The leaves, seeds and shoots contain hypoglycin A (HGA) and methylencyclopropylglycine (MCPRG) and can cause life-threatening atypical myopathy.
Publication Date: 2025-10-30 PubMed ID: 41176075DOI: 10.1016/j.jevs.2025.105713Google Scholar: Lookup
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Summary

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Lethal sycamore maple intoxication in a three-month-old foal occurred due to ingestion of toxic compounds present in parts of the maple tree, causing severe muscle disease. The report highlights the dangers of certain maple species to grazing horses.

Introduction to the Case

  • A three-month-old foal was observed to have symptoms related to muscle disease.
  • The investigation revealed poisoning caused by exposure to toxins from sycamore maple (Acer species).
  • Symptoms were consistent with atypical myopathy, a serious and often fatal muscle condition.

Source of Intoxication

  • Sycamore maple trees contain toxic compounds: hypoglycin A (HGA) and methylencyclopropylglycine (MCPG).
  • These toxins are located in various parts of the tree, including leaves, seeds, and shoots.
  • Horses ingesting these toxins while grazing are at risk of developing toxic myopathy.

Mechanism of Toxicity

  • Hypoglycin A (HGA) and MCPG disrupt normal muscle metabolism in horses.
  • This disruption leads to atypical myopathy, characterized by muscle cell damage and breakdown.
  • The resulting muscle damage can be severe enough to cause death, especially in young or vulnerable animals.

Clinical Implications

  • Horses grazing in areas with sycamore maple trees are at risk for poisoning.
  • Foals, such as the reported case, may be particularly susceptible due to age and grazing behavior.
  • Early recognition of symptoms and prevention of exposure are critical to avoid fatal outcomes.
  • This case underscores the importance of monitoring grazing environments and managing tree risks in horse pastures.

Conclusion

  • The report highlights a fatal case of sycamore maple intoxication in a very young foal.
  • It emphasizes the threat posed by certain Acer species to horses through toxic compounds.
  • Veterinarians and horse owners should be aware of this poisoning risk and aim to minimize exposure.

Cite This Article

APA
Janzen N, Sander J, Terhardt M, Mallek M, Smith H, Witt P, Theelen MJP. (2025). Lethal Sycamore maple intoxication in a grazing three-month-old foal. J Equine Vet Sci, 155, 105713. https://doi.org/10.1016/j.jevs.2025.105713

Publication

ISSN: 0737-0806
NlmUniqueID: 8216840
Country: United States
Language: English
Volume: 155
Pages: 105713
PII: S0737-0806(25)00371-5

Researcher Affiliations

Janzen, N
  • Hannover Medical School, Department of Clinical Chemistry, Carl-Neuberg-Str. 1, Hannover, Lower Saxony, 30625, Germany; Screening-Labor Hannover, Postbox 91 10 09, Hannover, Lower Saxony, 30430, Germany. Electronic address: janzen.nils@mh-hannover.de.
Sander, J
  • Screening-Labor Hannover, Postbox 91 10 09, Hannover, Lower Saxony, 30430, Germany.
Terhardt, M
  • Screening-Labor Hannover, Postbox 91 10 09, Hannover, Lower Saxony, 30430, Germany.
Mallek, M
  • MVZ Dr. Eberhard & Partner GbR, Brauhausstr. 4, Dortmund, North Rhine-Westphalia, 44137, Germany.
Smith, H
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, Utrecht, 3584 CM, The Netherlands.
Witt, P
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, Utrecht, 3584 CM, The Netherlands.
Theelen, M J P
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, Utrecht, 3584 CM, The Netherlands.

MeSH Terms

  • Animals
  • Acer / chemistry
  • Acer / poisoning
  • Horse Diseases / chemically induced
  • Horse Diseases / pathology
  • Horses
  • Hypoglycins / poisoning
  • Muscular Diseases / veterinary
  • Muscular Diseases / chemically induced
  • Plant Poisoning / veterinary

Conflict of Interest Statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Citations

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