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The Onderstepoort journal of veterinary research1990; 57(4); 269-275;

Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1.

Abstract: Leukoencephalomalacia (LEM) was induced by the oral administration of fumonisin B1 (FB1) to 2 horses: a filly received 59.5 mg/kg of a 50% preparation of FB1, administered in 21 doses of 1.25-4 mg/kg over 33 days; a colt, 44.3 mg/kg of 95% pure FB1 in 20 doses of 1-4 mg/kg in 29 days. Both animals developed nervous signs such as apathy, changes in temperament, inco-ordination, walking into objects, and one showed paralysis of the lips and tongue. Characteristic lesions of LEM were present in the brains. These trials proved conclusively that FB1 can induce LEM in horses.
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Publication Date: 1990-12-01 PubMed ID: 2293136
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research demonstrates that oral administration of fumonisin B1 (FB1) can cause Leukoencephalomalacia (LEM), a neurological disease, in horses.

Introduction to the Research

This research was conducted to investigate whether fumonisin B1 (FB1), when orally administered, could induce Leukoencephalomalacia (LEM) in horses. LEM is a fatal neurological disease that primarily affects horses and is caused by the fungal toxin fumonisin.

Methodology Used

  • Two horses, a filly and a colt, were included in the study.
  • The filly was given 59.5 mg/kg of a 50% preparation of FB1 in 21 separate doses ranging from 1.25 to 4 mg/kg during a 33-day period.
  • The colt was given 44.3 mg/kg of 95% pure FB1 in 20 separate doses ranging from 1 to 4 mg/kg in 29 days.

Observations and Findings

  • Both horses displayed nervous signs following the administration of FB1, including apathy, changes in temperament, incoordination, and walking into objects.
  • One horse also exhibited paralysis of the lips and tongue.
  • Upon examination, the presence of LEM lesions in the brains of these horses confirmed the development of the disease.

Conclusion

The research concluded that FB1, when orally administered, can induce LEM in horses, thereby confirming the link between FB1 and this neurological disorder. This study provides scientific evidence to support the need for preventive measures against FB1 exposure in horses to reduce the risk of LEM.

Cite This Article

APA
Kellerman TS, Marasas WF, Thiel PG, Gelderblom WC, Cawood M, Coetzer JA. (1990). Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort J Vet Res, 57(4), 269-275.

Publication

The Onderstepoort journal of veterinary research
ISSN: 0030-2465
NlmUniqueID: 0401107
Country: South Africa
Language: English
Volume: 57
Issue: 4
Pages: 269-275

Researcher Affiliations

Kellerman, T S
  • Veterinary Research Institute, Onderstepoort, Republic of South Africa.
Marasas, W F
    Thiel, P G
      Gelderblom, W C
        Cawood, M
          Coetzer, J A

            MeSH Terms

            • Animals
            • Brain / pathology
            • Encephalomalacia / chemically induced
            • Encephalomalacia / pathology
            • Encephalomalacia / veterinary
            • Female
            • Fumonisins
            • Horse Diseases / chemically induced
            • Horses
            • Mycotoxins / administration & dosage
            • Mycotoxins / poisoning
            • Time Factors

            Citations

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