Lincomycin-induced severe colitis in ponies: association with Clostridium cadaveris.
Abstract: Four groups of two ponies, free of fecal Salmonella and Clostridium cadaveris, were treated as follows: Group A, control group; B, single nasogastrically administered dose of lincomycin (25 mg/kg) followed 48 h later by 3 L of C. cadaveris (10(9) organisms/mL); C, the same dose of lincomycin as group B; D, the same dose of C. cadaveris as group B on each of three occasions at 12 h intervals. Groups A and D remained healthy, but groups B and C developed severe colitis 48-56 h (B) or 72 h (C) after administration of lincomycin. Three ponies were euthanized and one in group B died. Clostridium cadaveris was isolated at about 10(6)/mL of colonic contents from these ponies, but one pony in group B also yielded Salmonella typhimurium from the colon. Subsequent challenge of group A ponies (3 L of C. cadaveris 10(9)/mL, three times at 12 h intervals) did not produce colitis. Nasogastric administration of lincomycin (25 mg/kg) to group A and D ponies, 20 days after administration of C. cadaveris, resulted in severe colitis in all ponies within 48-72 h. Salmonella agona was isolated from the colonic contents of one pony and C. cadaveris (10(6)/mL) from all four ponies. Clostridium cadaveris was not isolated from the colonic content of 45 healthy horses examined immediately after death. These studies confirm the potential for lincomycin to induce severe enterocolitis in ponies and implicate C. cadaveris further as a cause of "idiopathic colitis" in ponies.
Publication Date: 1992-04-01 PubMed ID: 1591660PubMed Central: PMC1263527
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research examined the effects of lincomycin — a type of antibiotic — on ponies, with a focus on its potential to cause severe colitis termed “idiopathic colitis”, particularly in association with the bacterium Clostridium cadaveris.
Research Design
- The study involved four groups of two ponies each. All ponies were free from the bacteria Salmonella and Clostridium cadaveris (C. cadaveris).
- The groups were treated differently: Group A was the control group with no treatment, Group B received a single nasogastric administration of lincomycin and were exposed to C. cadaveris, Group C got the same dosage of lincomycin as Group B, and Group D received only doses of the C. cadaveris bacterium.
Findings
- Group A and D remained healthy, showing that neither the antibiotic nor the bacterium on its own led to colitis.
- Groups B and C developed severe colitis after the lincomycin administration. This suggests lincomycin induced colitis in the presence of C. cadaveris, or when administered on its own.
- Further, exposure to C. cadaveris post the lincomycin treatment also led to colitis in Group A and D ponies, indicating a relationship between the bacterium and antibiotic.
Significance
- This study, therefore, establishes the potential of lincomycin to induce enterocolitis in ponies.
- Notably, C. cadaveris was detected in the colonic contents of all ponies who developed colitis but was absent in 45 healthy horses. Therefore, the bacterium is implicated further as a causative agent in “idiopathic colitis” in ponies.
Implication
- These findings shed light on the interplay between antibiotics like lincomycin and bacteria such as C. cadaveris in the development of colitis in ponies, aiding better understanding and possibly more effective treatment of the disease condition.
Cite This Article
APA
Staempfli HR, Prescott JF, Brash ML.
(1992).
Lincomycin-induced severe colitis in ponies: association with Clostridium cadaveris.
Can J Vet Res, 56(2), 168-169.
Publication
Researcher Affiliations
- Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
MeSH Terms
- Animals
- Clostridium / isolation & purification
- Disease Models, Animal
- Enterocolitis, Pseudomembranous / microbiology
- Enterocolitis, Pseudomembranous / veterinary
- Horse Diseases / microbiology
- Horses
- Lincomycin
- Salmonella / isolation & purification
References
This article includes 4 references
- Can Vet J. 1991 Apr;32(4):232-7
- Vet Clin North Am. 1973 May;3(2):301-13
- Equine Vet J. 1988 Nov;20(6):417-20
- J Am Vet Med Assoc. 1963 Mar 1;142:510-1
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