Liposomal bupivacaine provides longer duration analgesia than bupivacaine hydrochloride in an adjustable sole-pressure model of equine lameness.
Abstract: To compare the efficacy and duration of action for perineural analgesia with liposomal bupivacaine (LB) versus bupivacaine hydrochloride (BHCl) in a sole-pressure induced model of forelimb lameness in horses. Methods: 6 healthy adult research horses. Methods: In 1 randomly assigned forelimb, grade 3/5 lameness was induced by use of a sole-pressure lameness model. Objective lameness (vector sum [VS]) was determined with an inertial sensor system at 0, 1, 6, and 24 hours after lameness induction to evaluate the model. Mechanical nociceptive thresholds (MNTs) and objective lameness (VS and force platform kinetics) were recorded prior to and at 1, 6, 24, 48, and 72 hours after perineural anesthesia of the palmar nerves at the level of the proximal sesamoid bones with LB or BHCl in random order, with a 1-week washout period between crossover treatments. Data analysis was performed with mixed-model ANOVA. Results: When evaluating the lameness model, there was a decrease in lameness at 24 hours in at least 1 limb of each horse (7/12 limbs); thus, screw length was increased by 1 to 2 mm at each 24-hour interval to maintain lameness. Compared with results at baseline, horses treated with BHCl had significant improvements in median MNT and VS identified at only 1 hour after injection, whereas treatment with LB yielded significantly improved median MNT, VS score, and peak vertical force for up to 24 hours. Conclusions: In this experimental model of forelimb lameness, LB provided longer analgesia when compared with BHCl and should be further investigated for treatment of pain in horses.
Publication Date: 2022-01-28 PubMed ID: 35092669DOI: 10.2460/ajvr.21.08.0132Google Scholar: Lookup
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- Clinical Trial
- Veterinary
- Journal Article
Summary
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The research study focuses on comparing two types of analgesics – liposomal bupivacaine (LB) and bupivacaine hydrochloride (BHCl) – for their duration and efficacy in treating lameness in horses. The results showed that LB provided longer relief for the horses compared to BHCl.
Objective and Methods
The goal of the experiment was to understand if LB could offer better and longer-lasting pain relief than BHCl when used in a sole-pressure induced model of forelimb lameness in horses. The model chosen was a sole-pressure lameness model that was adapted on one forelimb of 6 adult research horses to induce a grade 3/5 lameness.
- An inertial sensor system was used to measure the lameness at 0, 1, 6, and 24 hours after the lameness had been induced to evaluate the model.
- Both LB and BHCl were administered to the affected horses with a gap of one week to ensure that the previous drug had been washed out before the next one was introduced. The order was randomized.
- The analgesic efficacy was then measured through a set of indicators including mechanical nociceptive thresholds (MNTs), vector sum (VS), and force platform kinetics. These measurements were taken before, and at designated time intervals of 1, 6, 24, 48, and 72 hours after the anesthesia was administered for both LB and BHCl drugs.
Findings and Conclusion
The study showed that LB provided a more effective analgesic effect compared to BHCl.
- It was observed that, in comparison to the baseline, horses that were treated with BHCl showed significant improvement in their MNT and VS only 1 hour post-injection.
- On the other hand, horses treated with LB displayed significantly better median MNT, VS score, and peak vertical force which lasted up to 24 hours.
Therefore, the researchers concluded that, based on the results gained from this experimental model, LB has the potential to deliver longer-lasting analgesia as compared to BHCl in treating horse lameness. They suggest further investigation into the use of LB as a pain treatment in horses.
Cite This Article
APA
Moorman VJ, Pezzanite LM, Griffenhagen GM.
(2022).
Liposomal bupivacaine provides longer duration analgesia than bupivacaine hydrochloride in an adjustable sole-pressure model of equine lameness.
Am J Vet Res, 83(4), 298-304.
https://doi.org/10.2460/ajvr.21.08.0132 Publication
Researcher Affiliations
MeSH Terms
- Analgesia / veterinary
- Animals
- Bupivacaine / pharmacology
- Bupivacaine / therapeutic use
- Forelimb
- Horse Diseases
- Horses
- Lameness, Animal / drug therapy
- Pain / veterinary
Citations
This article has been cited 2 times.- Qiu RE, Lan YP, Liu S, Fang XY, Zhang YF. Comparison of Liposomal Bupivacaine versus Bupivacaine in Superficial Parasternal Intercostal Plane Block for Cardiac Surgery with Median Sternotomy. Ann Thorac Cardiovasc Surg 2025;31(1).
- Giambrone G, Catone G, Marino G, Gugliandolo E, Miloro R, Vullo C. Loco-Regional Anaesthesia during Standing Laparoscopic Ovariectomy in Equids: A Systematic Review (2003-2023) of the Literature. Animals (Basel) 2024 Aug 8;14(16).
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