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Home / Equine Research Bank / Acta Vet Scand / Listeria monocytogenes associated kerato-conjunctivitis in f...
Acta veterinaria Scandinavica2015; 57; 76; doi: 10.1186/s13028-015-0167-2

Listeria monocytogenes associated kerato-conjunctivitis in four horses in Norway.

Abstract: Listeria monocytogenes has been reported to cause various infectious diseases in both humans and animals. More rarely, ocular infections have been reported. To our knowledge, only two cases of Listeria keratitis have been described in horses. We report kerato-conjunctivitis in four Norwegian horses associated with L. monocytogenes. Clinically, all cases were presented with recurrent unilateral kerato-conjunctivitis. L. monocytogenes bacteria were isolated from swab samples from all cases, and cytology carried out in 3 cases was indicative of L. monocytogenes infection. The present report describes the first known cases in which L. monocytogenes has been isolated from keratitic lesions in horses in Norway. A potential risk factor may be feeding of silage or haylage, but other sources of infection cannot be ruled out. The phenotypic features including antimicrobial susceptibility and serotype of the isolates are described. Laboratory detection of L. monocytogenes demands extra caution since only low numbers of bacteria were detected in the eye-swabs, probably due to the low volume of sample material and the intracellular niche of the bacterium. A general poor response to treatment in all these cases indicates that clinicians should pay extra attention to intensity and duration of treatment if L. monocytogenes is identified in connection with equine kerato-conjunctivitis.
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Publication Date: 2015-11-09 PubMed ID: 26552393PubMed Central: PMC4638104DOI: 10.1186/s13028-015-0167-2Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research discusses the discovery of Listeria monocytogenes, a type of bacteria, causing kerato-conjunctivitis, an eye infection, in four horses from Norway, marking the first known instances of this in the region. The findings reveal challenges in treatment and identification of this bacteria.

Overview of the Study

  • The study reports on four cases of equine kerato-conjunctivitis, an eye infection in horses, caused by Listeria monocytogenes bacteria in Norway. This marks the first known instances of Listeria being the cause of this kind of infection in horses in the region.
  • The horses all had recurrent unilateral kerato-conjunctivitis and the bacteria was isolated from swabs taken from their eyes.
  • Cytology, the study of cells, was carried out in three of the cases and also indicated a Listeria monocytogenes infection.

Potential Risk Factors and Infection Sources

  • Although the precise source of the horses’ infections is unclear, the researchers suggest that a potential risk factor could be feeding the horses silage or haylage.
  • However, the researchers emphasized that other sources of infection couldn’t be ruled out, possibly including other feed or environmental contact points.

Challenges in Detection and Treatment

  • Detecting the bacteria in the lab proved challenging due to its low numbers in the eye-swab samples. This is thought to be due to the small sample material volume and the bacterium’s intracellular nature.
  • The treatment for this infection proved to be generally ineffective, making it important for veterinary clinicians to consider the intensity and duration of treatment when dealing with equine kerato-conjunctivitis possibly linked to Listeria monocytogenes.
  • The isolates of the bacteria presented certain phenotypic features, including serotype and antimicrobial susceptibility. These features are described in the study, providing a better understanding of the bacteria’s characteristics for future reference and treatment plans.

Importance of the Findings

  • The research’s findings are significant, as it’s the first recorded instance of this bacteria causing this type of infection in horses in Norway. This can increase the awareness in veterinary medicine about potential causes of equine kerato-conjunctivitis.
  • Additionally, the challenges faced in detecting and treating the bacteria present avenues for further research, with the aim of standardising a treatment protocol for this type of infection in the future.

Cite This Article

APA
Revold T, Abayneh T, Brun-Hansen H, Kleppe SL, Ropstad EO, Hellings RA, Sørum H. (2015). Listeria monocytogenes associated kerato-conjunctivitis in four horses in Norway. Acta Vet Scand, 57, 76. https://doi.org/10.1186/s13028-015-0167-2

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 57
Pages: 76
PII: 76

Researcher Affiliations

Revold, Tobias
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences (previously Norwegian School of Veterinary Science), Ullevålsveien 72, Postbox 8146 Dep, 0033, Oslo, Norway. tobias.revold@nmbu.no.
Abayneh, Takele
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences (previously Norwegian School of Veterinary Science), Ullevålsveien 72, Postbox 8146 Dep, 0033, Oslo, Norway. takeletefera99@gmail.com.
  • School of Veterinary Medicine, Addis Ababa University, Debre-Zeit, Ethiopia. takeletefera99@gmail.com.
Brun-Hansen, Hege
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences (previously Norwegian School of Veterinary Science), Ullevålsveien 72, Postbox 8146 Dep, 0033, Oslo, Norway. hege.brun-hansen@nmbu.no.
Kleppe, Signe L
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences (previously Norwegian School of Veterinary Science), Ullevålsveien 72, Postbox 8146 Dep, 0033, Oslo, Norway. signelundkleppe@gmail.com.
  • Aktiv Dyreklinikk, 1484, Hakadal, Norway. signelundkleppe@gmail.com.
Ropstad, Ernst-Otto
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences (previously Norwegian School of Veterinary Science), Ullevålsveien 72, Postbox 8146 Dep, 0033, Oslo, Norway. ernst.ropstad@nmbu.no.
Hellings, Robert A
  • Rikstotoklinikken Bjerke, Postboks 194, Økern, 0510, Oslo, Norway. fred.hellings@rikstoto.no.
Sørum, Henning
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences (previously Norwegian School of Veterinary Science), Ullevålsveien 72, Postbox 8146 Dep, 0033, Oslo, Norway. henning.sorum@nmbu.no.

MeSH Terms

  • Animals
  • Female
  • Horse Diseases / diagnosis
  • Horse Diseases / drug therapy
  • Horse Diseases / microbiology
  • Horses
  • Keratoconjunctivitis, Infectious / diagnosis
  • Keratoconjunctivitis, Infectious / drug therapy
  • Keratoconjunctivitis, Infectious / microbiology
  • Listeria monocytogenes / genetics
  • Listeria monocytogenes / isolation & purification
  • Listeriosis / diagnosis
  • Listeriosis / drug therapy
  • Listeriosis / microbiology
  • Listeriosis / veterinary
  • Male
  • Norway

References

This article includes 42 references
  1. Gray ML, Killinger AH. Listeria monocytogenes and listeric infections.. Bacteriol Rev 1966 Jun;30(2):309-82.
    pmc: PMC440999pubmed: 4956900doi: 10.1128/br.30.2.309-382.1966google scholar: lookup
  2. Radostits OM, Blood DC, Gay CC. Diseases caused by Listeria spp.. In: Veterinary medicine. 8th edition. London: Bailliere Tindall; 1994, p. 660-6.
  3. Wesley IV. Listeriosis in animals. In: Ryser ET, Marth EH, editors. Listeria, listeriosis, and food safety. New York: Marcel Dekker; 1999. pp. 39–40.
  4. Schlech WF 3rd. Lowbury Lecture. Listeriosis: epidemiology, virulence and the significance of contaminated foodstuffs.. J Hosp Infect 1991 Dec;19(4):211-24.
    doi: 10.1016/0195-6701(91)90238-4pubmed: 1686033google scholar: lookup
  5. Cullen CL, Webb AA. Ocular manifestations of systemic disease. Part 4: food animals. In: Gelatt KN, Gilger BC, Kern TJ, Ames IA (editors) Veterinary Ophthalmology. Volume 2. 5th edition. : Wiley-Blackwell; 2013. p. 2071–101.
  6. Erdogan HM, Cetinkaya B, Green LE, Green LE, Cripps PJ, Morgan KL. Prevalence, incidence, signs and treatment of clinical listeriosis in dairy cattle in England.. Vet Rec 2001 Sep 8;149(10):289-93.
    doi: 10.1136/vr.149.10.289pubmed: 11570788google scholar: lookup
  7. Pearce JW, Moore CP. Food animal ophthalmology. In: Gelatt KN, Gilger BC, Kern TJ, Ames IA, editors. Veterinary ophthalmology. Volume 2. 5th edition. Wiley-Blackwell; 2013. p. 1610–74.
  8. Eliott D, O'Brien TP, Green WR, Jampel HD, Goldberg MF. Elevated intraocular pressure, pigment dispersion and dark hypopyon in endogenous endophthalmitis from Listeria monocytogenes.. Surv Ophthalmol 1992 Sep-Oct;37(2):117-24.
    doi: 10.1016/0039-6257(92)90074-4pubmed: 1455294google scholar: lookup
  9. Zaidman GW, Coudron P, Piros J. Listeria monocytogenes keratitis.. Am J Ophthalmol 1990 Mar 15;109(3):334-9.
    doi: 10.1016/S0002-9394(14)74561-1pubmed: 2309867google scholar: lookup
  10. Altaie R, Fahy GT, Cormican M. Failure of Listeria monocytogenes keratitis to respond to topical ofloxacin.. Cornea 2006 Aug;25(7):849-50.
    doi: 10.1097/01.ico.0000230251.19847.3apubmed: 17068464google scholar: lookup
  11. Eiferman RA, Flaherty KT, Rivard AK. Persistent corneal defect caused by Listeria monocytogenes.. Am J Ophthalmol 1990 Jan 15;109(1):97-8.
    doi: 10.1016/S0002-9394(14)75592-8pubmed: 2297040google scholar: lookup
  12. Duch ST, Quintana MC, Pujol OG. Listeria monocytogenes endophthalmitis.. Acta Ophthalmol (Copenh) 1991 Feb;69(1):108-10.
    doi: 10.1111/j.1755-3768.1991.tb02004.xpubmed: 2028755google scholar: lookup
  13. Alkatan HM, Al-Dhibi HA, Edward DP, Al-Rajhi AA. Pigmented hypopyon in association with Listeria monocytogenes endopthalmitis: an interesting case report following refractive surgery procedure with literature review.. Middle East Afr J Ophthalmol 2014 Jan-Mar;21(1):40-3.
    doi: 10.4103/0974-9233.124090pmc: PMC3959040pubmed: 24669144google scholar: lookup
  14. Mason RW, Brennan RG, Corbould A. Listeria monocytogenes abortion in a mare. Austr Vet J 1980;56:613.
    doi: 10.1111/j.1751-0813.1980.tb02627.xgoogle scholar: lookup
  15. Welsh RD. Equine abortion caused by Listeria monocytogenes serotype 4.. J Am Vet Med Assoc 1983 Feb 1;182(3):291.
    pubmed: 6402475
  16. Mayer H, Kinzler M, Sickel E. [Listeriosis in a riding-horse stock].. Berl Munch Tierarztl Wochenschr 1976 Jun 1;89(11):209-11.
    pubmed: 820329
  17. Higgins R, Goyette G, Sauvageau R, Lemaire T. Septicemia due to listeria monocytogenes in a newborn foal.. Can Vet J 1987 Jan;28(1-2):63.
    pmc: PMC1680375pubmed: 17422889
  18. Pirs T, Zdovc I, Gombac M, Svara T, Juntes P, Vengust M. Listeria monocytogenes septicaemia in a foal. Slov Vet Res 2005;42:49–53.
  19. Clark EG, Turner AS, Boysen BG, Rouse BT. Listeriosis in an Arabian foal with combined immunodeficiency.. J Am Vet Med Assoc 1978 Feb 1;172(3):363-6.
    pubmed: 413818
  20. Rütten M, Lehner A, Pospischil A, Sydler T. Cerebral listeriosis in an adult Freiberger gelding.. J Comp Pathol 2006 Feb-Apr;134(2-3):249-53.
    doi: 10.1016/j.jcpa.2005.09.007pubmed: 16542674google scholar: lookup
  21. Monteiro F, Wong D, Scarratt WK, Buechner-Maxwell V, Crisman M. Listeria monocytogenes septicaemia in two neonatal foals. Equine Vet Educ 2006;18:27–31.
    doi: 10.1111/j.2042-3292.2006.tb00409.xgoogle scholar: lookup
  22. Gudmundsdottir KB, Svansson V, Aalbaek B, Gunnarsson E, Sigurdarson S. Listeria monocytogenes in horses in Iceland.. Vet Rec 2004 Oct 9;155(15):456-9.
    doi: 10.1136/vr.155.15.456pubmed: 15518406google scholar: lookup
  23. Jose-Cunilleras E, Hinchcliff KW. Listeria monocytogenes septicaemia in foals.. Equine Vet J 2001 Sep;33(5):519-22.
    doi: 10.2746/042516401776254727pubmed: 11558750google scholar: lookup
  24. Wilkins PA, Marsh PS, Acland H, Del Piero F. Listeria monocytogenes septicemia in a Thoroughbred foal.. J Vet Diagn Invest 2000 Mar;12(2):173-6.
    doi: 10.1177/104063870001200216pubmed: 10730952google scholar: lookup
  25. Sanchez S, Studer M, Currin P, Barlett P, Bounous D. Listeria keratitis in a horse.. Vet Ophthalmol 2001 Sep;4(3):217-9.
    doi: 10.1046/j.1463-5216.2001.00179.xpubmed: 11722787google scholar: lookup
  26. Evans K, Smith M, McDonough P, Wiedmann M. Eye infections due to Listeria monocytogenes in three cows and one horse.. J Vet Diagn Invest 2004 Sep;16(5):464-9.
    doi: 10.1177/104063870401600519pubmed: 15460335google scholar: lookup
  27. English R, Gilger BC. Ocular immunology. In: Gelatt KN, Gilger BC, Kern TJ, Ames IA, editors. Veterinary Ophthalmology. Volume 1. 5th edition. Wiley-Blackwell; 2013. p. 273–299.
  28. Rácz P, Tenner K, Szivessy K. Electron microscopic studies in experimental keratoconjunctivitis listeriosa. I. Penetration of Listeria monocytogenes into corneal epithelial cells.. Acta Microbiol Acad Sci Hung 1970;17(3):221-36.
    pubmed: 4101180
  29. Morris MC, Julianelle LA. A study of an infection induced experimentally with bacterium monocytogenes. Am J Ophthalmol 1935;18:535–541.
    doi: 10.1016/S0002-9394(35)93550-4google scholar: lookup
  30. Julianelle LA, Pons CA. Identification of Listerella monocytogenes. Proc Soc Exp Biol Med 1939;40:362–363.
    doi: 10.3181/00379727-40-10415Pgoogle scholar: lookup
  31. Ledbetter EC, Scarlett JM. In vivo confocal microscopy of the normal equine cornea and limbus.. Vet Ophthalmol 2009 Nov-Dec;12 Suppl 1:57-64.
    doi: 10.1111/j.1463-5224.2009.00730.xpubmed: 19891653google scholar: lookup
  32. Pirie CG, Alario AF, Barysauskas CM, Gradil C, Uricchio CK. Manual corneal thickness measurements of healthy equine eyes using a portable spectral-domain optical coherence tomography device.. Equine Vet J 2014 Sep;46(5):631-4.
    doi: 10.1111/evj.12198pubmed: 24131285google scholar: lookup
  33. Reiser BJ, Ignacio TS, Wang Y, Taban M, Graff JM, Sweet P, Chen Z, Chuck RS. In vitro measurement of rabbit corneal epithelial thickness using ultrahigh resolution optical coherence tomography.. Vet Ophthalmol 2005 Mar-Apr;8(2):85-8.
    doi: 10.1111/j.1463-5224.2005.00345.xpubmed: 15762921google scholar: lookup
  34. Braun U, Stehle C, Ehrensperger F. Clinical findings and treatment of listeriosis in 67 sheep and goats.. Vet Rec 2002 Jan 12;150(2):38-42.
    doi: 10.1136/vr.150.2.38pubmed: 11829065google scholar: lookup
  35. Morgan JH. Infectious keratoconjunctivitis in cattle associated with Listeria monocytocytogenes.. Vet Rec 1977 Feb 5;100(6):113-4.
    doi: 10.1136/vr.100.6.113pubmed: 402729google scholar: lookup
  36. Kummeneje K, Mikkelsen T. Isolation of Listeria monocytogenes type 04 from cases of keratoconjunctivitis in cattle and sheep.. Nord Vet Med 1975 Mar;27(3):144-9.
    pubmed: 806058
  37. Welchman D, Hooton JK, Low JC. Ocular disease associated with silage feeding and Listeria monocytogenes in fallow deer.. Vet Rec 1997 Jun 28;140(26):684-5.
    doi: 10.1136/vr.140.26.684pubmed: 9234555google scholar: lookup
  38. Fenlon DR. Listeria monocytogenes in the natural environment. In: Ryser ET, Marth EH, editors. Listeria, listeriosis and food safety. 2nd edition. New York: Marcel Dekker; 1999. p. 21–37.
  39. Walker JK, Morgan JH. Ovine ophthalmitis associated with Listeria monocytogenes.. Vet Rec 1993 Jun 19;132(25):636.
    doi: 10.1136/vr.132.25.636pubmed: 8351784google scholar: lookup
  40. Regnier A. Antimicrobials, Antiinfalmmatory Agents, and Antiglaucoma Drugs. In: Gelatt KN, Ames IA, editors. Veterinary ophthalmology. Volume 1. 4th edition. Blackwell Publishing; 2007. p. 288–331.
  41. Riff LJ, Thomason JL. Comparative aminoglycoside inactivation by beta-lactam antibiotics. Effects of a cephalosporin and six penicillins on five aminoglycosides.. J Antibiot (Tokyo) 1982 Jul;35(7):850-7.
    doi: 10.7164/antibiotics.35.850pubmed: 7174538google scholar: lookup
  42. Tay E, Rajan M, Tuft S. Listeria monocytogenes sclerokeratitis: a case report and literature review.. Cornea 2008 Sep;27(8):947-9.
    doi: 10.1097/ICO.0b013e31816c4078pubmed: 18724160google scholar: lookup

Citations

This article has been cited 4 times.
  1. Phelps S, Chong D, McKenzie E, Kiupel M, Gorman E. Rapport de cas Mononuclear pleocytosis and meningoencephalitis caused by Listeria monocytogenes in an adult horse.. Can Vet J 2023 Apr;64(4):363-366.
    pubmed: 37008639
  2. Elbert JA, Rissi DR. Systemic Listeria monocytogenes infection and concurrent pleural mesothelioma in a cat.. J Vet Diagn Invest 2021 Jan;33(1):120-123.
    doi: 10.1177/1040638720966321pubmed: 33054600google scholar: lookup
  3. Wei P, Bao R, Fan Y. Brainstem Encephalitis Caused by Listeria monocytogenes.. Pathogens 2020 Aug 30;9(9).
    doi: 10.3390/pathogens9090715pubmed: 32872638google scholar: lookup
  4. Marlo TL, Giuliano EA, Sharma A, Mohan RR. Development of a novel ex vivo equine corneal model.. Vet Ophthalmol 2017 Jul;20(4):288-293.
    doi: 10.1111/vop.12415pubmed: 27471196google scholar: lookup
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