Local photodynamic therapy delays recurrence of equine periocular squamous cell carcinoma compared to cryotherapy.
Abstract: (i) To report the successful treatment of 10 cases of equine periocular squamous cell carcinoma (PSCC) with surgical excision and photodynamic therapy (PDT) using verteporfin. (ii) To evaluate time to first tumor recurrence between PDT-treated horses and horses treated with surgical excision and cryotherapy. Methods: A total of 24 equine PSCC cases were included: group 1 (n = 14) had excision and cryotherapy (1993–2003), group 2 (n = 10), excision and local PDT (2006–2010). Evaluated data: signalment, treatment method, tumor location, size, and time to first recurrence. Groups were compared via chi-square test for categorical variables and Wilcoxon rank-sum test for numeric variables. Time to tumor recurrence was examined using Kaplan–Meier product-limit survival analysis. Results: Of 24 cases, nine breeds were affected. Mean age at treatment in years: 14 (range 5–24) in group 1; 11 (range 8–18) in group 2. Median tumor size: 163 mm2 (range 20–625 mm2) in group 1; 195 mm2 (range 45–775 mm2) in group 2. Signalment, tumor laterality, and size were not significantly different between groups. Time to recurrence was significantly different between groups (Logrank test, P = 0.0006). In group 1, 11/14 horses had tumor regrowth with median time to recurrence in months: 10 (range 1–44). In group 2 (minimum follow-up of 25 months; range 25–50), no horse demonstrated tumor recurrence after one treatment with excision and PDT. Conclusions: This represents the first report of local PDT using verteporfin for treatment of equine PSCC. Following surgery, the likelihood of tumor recurrence was significantly reduced with local PDT compared with cryotherapy.
© 2013 American College of Veterinary Ophthalmologists.
Publication Date: 2014-08-16 PubMed ID: 25126663DOI: 10.1111/vop.12099Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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The article reports on a study comparing the effectiveness of photodynamic therapy versus cryotherapy in treating equine periocular squamous cell carcinoma (PSCC), a type of eye cancer in horses. The study found that photodynamic therapy notably prolonged the time until cancer recurrence as compared to cryotherapy.
Study Design and Methods
- The research explored the impact of two treatment regimens on equine PSCC. A group of equine PSCC cases, carried out between 1993 and 2010, were analyzed.
- Group 1 consisted of 14 horses treated with surgical excision and cryotherapy between 1993 and 2003.
- Group 2 involved 10 horses treated with surgical excision and local photodynamic therapy (PDT) using verteporfin from 2006 to 2010.
- The research compared variables such as the horses’ characteristics, therapy method, tumor location and size, and time to the first tumor recurrence.
- Statistical analyses including the chi-square test, Wilcoxon rank-sum test, and Kaplan-Meier survival analysis were employed to compare results between the groups.
Research Findings
- Nine different horse breeds were included in the study with ages ranging from 5 to 24 years.
- Tumor sizes varied within both groups, but there were no significant differences in terms of breed, age, tumor size, or location between the two groups.
- However, a significant difference was found in the time to the first tumor recurrence between the two groups. Group 1 had 11 out of 14 horses experience tumor regrowth with an average recurrence time of 10 months.
- On the other hand, in Group 2, none of the horses showed symptoms of tumor recurrence after one treatment with surgery and PDT, with a follow-up period between 25-50 months.
Research Implications
- This study is the first to report on local PDT using verteporfin as a treatment for equine PSCC. The data suggests PDT after surgical removal significantly reduces the likelihood of tumor recurrence compared to using cryotherapy.
- The findings indicate that integrating PDT into equine PSCC treatment regimens would be more effective, despite no significant differences being identified between the groups in terms of patient characteristics.
Cite This Article
APA
Giuliano EA, Johnson PJ, Delgado C, Pearce JW, Moore CP.
(2014).
Local photodynamic therapy delays recurrence of equine periocular squamous cell carcinoma compared to cryotherapy.
Vet Ophthalmol, 17 Suppl 1, 37-45.
https://doi.org/10.1111/vop.12099 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antineoplastic Agents / therapeutic use
- Carcinoma, Squamous Cell / drug therapy
- Carcinoma, Squamous Cell / surgery
- Carcinoma, Squamous Cell / veterinary
- Cryosurgery / methods
- Cryosurgery / veterinary
- Eye Neoplasms / drug therapy
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Horse Diseases / therapy
- Horses
- Kaplan-Meier Estimate
- Male
- Neoplasm Recurrence, Local / prevention & control
- Neoplasm Recurrence, Local / veterinary
- Photochemotherapy / methods
- Photochemotherapy / veterinary
- Porphyrins / therapeutic use
- Verteporfin
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