Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken.
Abstract: In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors. In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established. We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken. Dogs were of different breeds and were aged 2 months to 15 years. The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine. The 2 horses were 11 and 12 years old. The equine tumors were located in the subcutis of the neck and axilla. The chicken was a mature white Leghorn chicken with an ocular neoplasm. Neurofibromas of this study had localized, plexiform, diffuse and combined plexiform and diffuse growth patterns, and microscopic features similar to those in classic, collagenous, cellular, myxoid, and pigmented neurofibromas of humans. One diffuse neurofibroma contained areas of schwannian differentiation (hybrid neurofibroma-schwannoma). Two plexiform neurofibromas occurred together with diffuse ganglioneuromatosis in the large intestine of young dogs, as has also been reported in humans. This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans. This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.
Publication Date: 2009-05-09 PubMed ID: 19429995DOI: 10.1354/vp.08-VP-0322-S-FLGoogle Scholar: Lookup
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- Journal Article
Summary
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This research paper discusses the investigation resulting in the identification of subtypes of neurofibroma, a type of benign peripheral nerve sheath tumor, in various species of animals. It highlights the similarities between human and animal neurofibromas, pinpointing common factors in tumor location and patient age, ultimately offering further insights in diagnosis, epidemiology, and prognosis of this condition.
Research Purpose and Context
- The primary goal of this research was to scrutinize benign peripheral nerve sheath tumors in various animal species, similar to the neurofibroma and schwannoma subtypes seen in humans. The study intended to provide a basis for a more refined classification of these tumors in the veterinary field.
- In veterinary medicine, these tumors are often broadly classified as benign peripheral nerve sheath tumors, with the specific criteria for further classification not well established.
Research Process and Findings
- The study incorporated 12 dogs, 2 horses, and 1 chicken, all of different breeds and ages, suffering from peripheral nerve sheath tumors.
- The researchers conducted microscopic, immunohistologic, and ultrastructural examination of these tumors. They observed that the tumors had characteristics similar to those found in subtypes of human neurofibroma.
- The tumors in the dogs were located in various places including the skin, tongue, large intestine, and peripheral nerve. The horse’s tumors were located in the subcutis of the neck and axilla. The chicken, a mature white Leghorn, had an ocular neoplasm.
- Identified variants of neurofibromas showed localized, plexiform, diffuse, and combined plexiform and diffuse growth patterns, akin to the patterns observed in human neurofibromas.
- One diffuse neurofibroma demonstrated areas of schwannian differentiation, indicating a hybrid neurofibroma-schwannoma.
- Two plexiform neurofibromas were found in conjunction with diffuse ganglioneuromatosis in the large intestine of young dogs, a finding that mirrors what has been previously reported in humans.
Conclusion and Impact
- The study established the existence of identical subtypes of neurofibroma in animals and humans, highlighting commonalities in terms of tumor location and age of the patient.
- The findings of the research offer a foundation for more comprehensive classification of benign peripheral nerve sheath tumors in the veterinary field.
- The results may also affect the understanding of the epidemiology, pathogenesis, and prognosis of these tumors, enriching both human and veterinary medicine.
Cite This Article
APA
Schöniger S, Summers BA.
(2009).
Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken.
Vet Pathol, 46(5), 904-915.
https://doi.org/10.1354/vp.08-VP-0322-S-FL Publication
Researcher Affiliations
- Department of Pathology and Infectious Disease, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK. sschoeniger@rvc.ac.uk
MeSH Terms
- Animals
- Chickens
- Dog Diseases / pathology
- Dogs
- Female
- Horse Diseases / pathology
- Horses
- Immunohistochemistry / veterinary
- Male
- Microscopy, Electron, Transmission / veterinary
- Neurofibroma / pathology
- Neurofibroma / ultrastructure
- Poultry Diseases / pathology
- Retrospective Studies
Citations
This article has been cited 12 times.- Lee D, Yun H, Yun T, Koo Y, Chae Y, Nam H, Kang S, Lee H, Chang D, Yang MP, Kang BT, Kim H. 18F-fluorodeoxyglucose positron emission tomography findings of peripheral nerve sheath tumour of the nasal cavity in a dog.. Vet Med Sci 2023 Mar;9(2):584-590.
- Ahn H, Song WJ, Choi S, Kim JH, Jung JY, Cheong J, Park H, Jeong H, Yun Y. A rare case of cecal malignant peripheral nerve sheath tumor in a dog.. J Vet Med Sci 2022 Aug 1;84(8):1051-1055.
- Tekavec K, Švara T, Knific T, Gombač M, Cantile C. Histopathological and Immunohistochemical Evaluation of Canine Nerve Sheath Tumors and Proposal for an Updated Classification.. Vet Sci 2022 Apr 22;9(5).
- Castiglioni V, Caielli C, Guenzi G, Sacchini F. Cutaneous spindle cell tumors with features of peripheral nerve sheath tumors and concurrent cardiac involvement: neurofibromatosis type 1-like presentation in a Labrador Retriever dog.. J Vet Diagn Invest 2022 May;34(3):535-538.
- Armando F, Pigoli C, Gambini M, Ghidelli A, Ghisleni G, Corradi A, Passeri B, Caniatti M, Grieco V, Baumgärtner W, Puff C. Peripheral Nerve Sheath Tumors Resembling Human Atypical Neurofibroma in Goldfish (Carassius auratus, Linnaeus, 1758).. Animals (Basel) 2021 Sep 7;11(9).
- Osum SH, Watson AL, Largaespada DA. Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1.. Int J Mol Sci 2021 Feb 16;22(4).
- Rinnovati R, Xenos S, Beltrame A, Marigo A, Forni G, Morini M. Subcutaneous neurofibroma as a cause of lameness in a warmblood horse: Neurofibroma in a horse.. J Equine Sci 2020 Oct;31(3):45-48.
- Dobromylskyj MJ, Martinez F, Lovell A. Spindle cell sarcomas, suggestive of peripheral nerve sheath tumours, arising in the tongues of two cats.. JFMS Open Rep 2019 Jul-Dec;5(2):2055116919875259.
- Basa RM, Crowley AM, Johnson KA. Neurofibroma of the ulnar nerve in the carpal canal in a dog: treatment by marginal neurectomy.. J Small Anim Pract 2020 Aug;61(8):512-515.
- Ribas A, Miller R, Rasotto R. Small intestinal peripheral nerve sheath tumour in a cat.. JFMS Open Rep 2017 Jan-Jun;3(1):2055116917710394.
- Miller AD, Baitchman EJ, Masek-Hammerman K. Multiple endocardial neurofibromas in a rosy-billed pochard (Netta peposaca).. J Vet Diagn Invest 2012 Mar;24(2):408-11.
- Alves DA, Bell TM, Benton C, Rushing EJ, Stevens EL. Giant thoracic schwannoma in a rhesus macaque (Macaca mulatta).. J Am Assoc Lab Anim Sci 2010 Nov;49(6):868-72.
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