Luteinizing hormone concentrations in healthy horses and horses with trigeminal-mediated headshaking over an 8-hour period.
Abstract: Trigeminal-mediated headshaking results from a low threshold for firing of the trigeminal nerve. A seasonal component has been implicated in onset of clinical signs, which occur during the spring and summer months. Geldings are overrepresented in the affected population and hormonal differences as compared to a healthy control population of geldings might contribute to headshaking. Objective: To assess concentrations of luteinizing hormone (LH) over an 8-hour period in gelded healthy controls and horses affected with headshaking. Our hypothesis was that geldings with seasonal headshaking would have higher concentrations of LH over an 8-hour period compared to control horses during the summer when affected horses manifested headshaking. Methods: Twelve geldings (6 controls and 6 affected). Methods: Prospective controlled trial. Blood samples were drawn every 15 minutes over an 8-hour time period during summer from all horses to measure circulating LH concentrations by using a radioimmunoassay for equine LH. All affected horses were actively affected by headshaking at the time of sample collection. Results: No statistically significant differences in LH concentrations were found throughout the study period in headshakers as compared to control horses. Time had no significant effect, but a slight decrease in LH concentrations was observed for all horses. The main limitation of the study was the low number of horses. Conclusions: Horses affected with headshaking did not have significant differences in circulating LH during the late summer as compared to control horses.
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
Publication Date: 2019-02-17 PubMed ID: 30773684PubMed Central: PMC6430929DOI: 10.1111/jvim.15451Google Scholar: Lookup
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- Journal Article
Summary
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The research article focuses on a study that aimed to identify whether horses with trigeminal-mediated headshaking had differing luteinizing hormone (LH) concentrations compared to healthy control horses over an 8-hour period in summer. The findings indicated no significant differences in LH concentrations between the two groups.
Objective and Hypothesis
- The goal of the study was to assess the concentrations of luteinizing hormone over an 8-hour period in both healthy horses and those suffering from trigeminal-mediated headshaking.
- The researchers hypothesized that geldings with seasonal headshaking would exhibit higher concentrations of luteinizing hormone when compared to the control group during the summer period when the affected horses exhibited headshaking symptoms.
Methodology
- A prospective controlled trial was adopted as the primary research methodology. This involved assessing luteinizing hormone concentrations over an 8-hour period.
- The sample population for the study consisted of twelve geldings, with half being healthy controls and the other half suffering from headshaking.
- Blood samples were collected every 15 minutes over the stated period and analyzed to determine LH concentrations using a radioimmunoassay specifically for equine LH. It should be noted that samples were only taken from horses who were in an active state of headshaking.
Results and Conclusion
- The results of the study indicated that there were no statistically significant differences in the concentrations of luteinizing hormone in horses with headshaking when compared to those in the control group.
- The analysis of data also showed that the time of day had no significant impact on LH concentrations. However, a minor decrease in LH concentrations was noticed in all horses.
- Despite the research outcomes, it was acknowledged that the study was limited by the low sample size.
- In conclusion, the research findings suggested that horses affected with trigeminal-mediated headshaking did not exhibit significant differences in circulating luteinizing hormone during the summer as compared to control horses.
Cite This Article
APA
Sheldon SA, Aleman M, Costa LRR, Santoyo AC, Weich KM, Howey Q, Madigan JE.
(2019).
Luteinizing hormone concentrations in healthy horses and horses with trigeminal-mediated headshaking over an 8-hour period.
J Vet Intern Med, 33(2), 885-888.
https://doi.org/10.1111/jvim.15451 Publication
Researcher Affiliations
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
MeSH Terms
- Animals
- Behavior, Animal / physiology
- Head / physiopathology
- Horse Diseases / physiopathology
- Horses
- Luteinizing Hormone / blood
- Male
- Radioimmunoassay / veterinary
- Seasons
- Trigeminal Nerve / physiopathology
Grant Funding
- Not applicable / Gift from anonymous donor
Conflict of Interest Statement
Authors declare no conflict of interest.
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Citations
This article has been cited 1 times.- Wright S. Highlights of recent clinically relevant papers.. Equine Vet Educ 2019 Sep;31(9):450-451.
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