Lymphadenopathy-associated virus: from molecular biology to pathogenicity.
Abstract: Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in genome structure and biological properties, allows LAV to be placed in the retroviral subfamily of Lentivirinae. Molecular data indicate a high degree of genetic variation of the virus, especially in the envelope gene, which have important implications for the origin of the virus (the T4 lymphotropism may be a recently acquired property) and for future immunization. Another problem is the role of viral infection in the induction of irreversible immunodeficiency. This syndrome occurs in a minority of infected persons, who generally have in common a past of antigenic stimulation and of immune depression before LAV infection.
Publication Date: 1985-11-01 PubMed ID: 2996400DOI: 10.7326/0003-4819-103-5-689Google Scholar: Lookup
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Summary
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The research article investigates the lymphadenopathy-associated virus (LAV) and its similarities to other lentiviruses found in animals. Furthermore, it looks into the genetic variations of this virus and its potential implications for the origin of the virus and future vaccinations.
Examination of the Lymphadenopathy-Associated Virus
In this article, recent data suggests that the lymphadenopathy-associated virus shares a morphological similarity with animal lentiviruses, such as the equine infectious anemia and visna viruses.
- Further evidence of this similarity is found in the cross-reactivity of the LAV’s core proteins with those of the equine infectious anemia virus. There is also a correlation detected in the genome structure and biological properties between these two viruses.
- Based on these findings, the researchers place LAV in the retroviral subfamily of Lentivirinae.
Genetic Variation in LAV
The researchers also focused on the genetic variation within the LAV species.
- High genetic variations were observed, particularly within the envelope gene of the virus.
- These variations have important implications, first for understanding the origin of the virus and, second, for future immunization efforts. It is suggested that LAV’s T4 lymphotropism property could have been recently acquired, referencing the virus’s mutable characteristics.
LAV and Immune Deficiency Implications
Another significant concern addressed in this paper is the potential role of viral infections, particularly LAV, in inducing irreversible immunodeficiency.
- This syndrome, characterized by a deficient immune response, occurs in a small proportion of people infected with LAV.
- Common factors amongst these individuals include previous antigenic stimulation and a history of immune depression prior to LAV infection.
- Interpreting these findings could provide valuable insights into why only a minority develops severe immunodeficiency, and these findings could potentially lead to improved treatment or preventive measures.
Cite This Article
APA
Montagnier L.
(1985).
Lymphadenopathy-associated virus: from molecular biology to pathogenicity.
Ann Intern Med, 103(5), 689-693.
https://doi.org/10.7326/0003-4819-103-5-689 Publication
Researcher Affiliations
MeSH Terms
- Acquired Immunodeficiency Syndrome / immunology
- Acquired Immunodeficiency Syndrome / microbiology
- Animals
- Antibodies, Viral / analysis
- Deltaretrovirus / analysis
- Deltaretrovirus / immunology
- Deltaretrovirus / pathogenicity
- Deltaretrovirus / ultrastructure
- Gene Products, gag
- Humans
- Retroviridae Proteins / analysis
- Risk
- T-Lymphocytes / microbiology
- Viral Envelope Proteins / analysis
- Viral Proteins / analysis
Citations
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