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Management of twin conceptuses by manual embryonic reduction: comparison of two techniques and three hormone treatments.
Abstract: One hundred mares carrying twin conceptuses between gestation days (GD) 12 and 30 were assigned to 4 groups. Group-1 mares (n = 20) were given a placebo (sterile saline solution, IV, and sesame oil, IM). Group-2 mares (n = 32) were given a single dose of progesterone (625 mg, IM) in sesame oil. Group-3 mares (n = 28) were given multiple progesterone treatments (625 mg, IM) at 6-day intervals until GD 42. Group-4 mares (n = 20) were given a single treatment of flunixin meglumine (500 mg, IV) and progesterone (625 mg, IM). Each group was further assigned to equal subgroups A and B according to the age of the embryos. In subgroup A, with embryos at GD 12 to 16, embryonic vesicle rupture was performed after the selected conceptus was moved to the tip of a uterine horn. In subgroup B, with embryos at GD 17 to 30, embryonic vesicle rupture was performed on the selected conceptus in situ. An additional 6 mares carrying single conceptuses (GD 12, 14, 16, 20, 25, and 30) were used as subjects for sham embryonic vesicle rupture. Both rupture techniques usually caused the release of prostaglandin (PG) F2 alpha for up to 90 minutes. Amounts of PGF2 alpha were directly correlated with the pressure required to effect embryonic vesicle rupture. Sham embryonic vesicle rupture attempts caused small PGF2 alpha releases after each manipulation, which rapidly returned to basal values. All 6 mares were still pregnant at GD 42. Flunixin meglumine inhibited PGF2 alpha release after embryonic vesicle rupture, regardless of the technique.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1987-11-01 PubMed ID: 3434903 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research study involves an examination of how to manage mares carrying twin pregnancies by manually reducing the number of embryos using different techniques and hormonal treatments. This is done in order to understand the subsequent effects on hormone release and pregnancy viability.
Research Methodology
The researchers divided one hundred pregnant mares into four groups, with varying methods of hormone treatment given to each group.
- Group 1 was given a placebo to serve as a control group.
- In Group 2, the mares were given a single dose of progesterone.
- Group 3 received multiple doses of progesterone at 6-day intervals until gestation day 42.
- Group 4 received a single dose of both flunixin meglumine, a non-steroidal anti-inflammatory drug, and progesterone.
Subgroups were then created based on the age of the embryos, with subgroup A having younger embryos and subgroup B older ones. The technique performed in these subgroups involved the rupture of the embryonic vesicle, either after it was moved to the tip of the uterine horn or in situ (in its original place).
Research Findings
The process of rupturing the embryonic vesicle generally caused a release of a hormone called prostaglandin (PG) F2 alpha for a duration of up to 90 minutes. The amount of this hormone released was directly related to the pressure needed to cause the vesicle rupture.
Attempting to rupture the vesicle but not actually doing so (sham vesicle rupture) also caused a brief release of PGF2 alpha. Despite this, all mares who had a sham vesicle rupture remained pregnant until gestation day 42.
The research findings also showed that the treatment of flunixin meglumine reduced the amount of PGF2 alpha release after the embryonic vesicle rupture. This was observed irrespective of the technique used to rupture the vesicle.
The study does not continue beyond this point in the abstract, but the findings suggest that flunixin meglumine might play a role in maintaining pregnancy after manual embryonic reduction by inhibiting the release of PGF2 alpha.
Cite This Article
APA
Pascoe DR, Pascoe RR, Hughes JP, Stabenfeldt GH, Kindahl H.
(1987).
Management of twin conceptuses by manual embryonic reduction: comparison of two techniques and three hormone treatments.
Am J Vet Res, 48(11), 1594-1599.
Publication
Researcher Affiliations
- Department of Reproduction, School of Veterinary Medicine, University of California, Davis 95616.
MeSH Terms
- Animals
- Clonixin / administration & dosage
- Clonixin / analogs & derivatives
- Clonixin / pharmacology
- Female
- Horses / physiology
- Injections, Intramuscular
- Injections, Intravenous
- Nicotinic Acids / pharmacology
- Pregnancy
- Pregnancy, Animal / drug effects
- Pregnancy, Multiple / drug effects
- Progesterone / administration & dosage
- Progesterone / pharmacology
- Twins
Citations
This article has been cited 3 times.- Veronesi MC, De Amicis I, Giangaspero BA, Fusi J, Robbe D, Castelli F, Carluccio A. Twin Pregnancy in the Martina Franca Donkey Breed Managed by Natural Reduction and Post-Fixation Manual Crushing. Animals (Basel) 2024 Aug 29;14(17).
- Roach J, Arango Sabogal JC, Smith K, Foote A, Verheyen K, de Mestre AM. Multivariable analysis to determine risk factors associated with abortion in mares. Reprod Fertil 2022 Nov 1;3(4):301-12.
- Raggio I, Lefebvre RC, Poitras P, Vaillancourt D, Goff AK. Twin pregnancy experimental model for transvaginal ultrasound-guided twin reduction in mares. Can Vet J 2008 Nov;49(11):1093-8.
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