Mast cell tumor invading the cornea in a horse.
Abstract: A 3-year-old Marwari mare was presented for evaluation of an irregular, reddish mass protruding from behind the right third eyelid. The mass appeared to arise at the ventral limbal area, involved the perilimbal bulbar conjunctiva and widely extended into corneal tissue. No other ocular or systemic abnormalities were detected at the time of presentation. The mass was surgically removed by lamellar keratectomy, with defocused CO(2) laser used as adjunctive therapy to treat the surgical exposed area and its surroundings. Histopathologic evaluation showed sheets of densely packed, well-differentiated neoplastic mast cells separated by fibrovascular connective tissue. Nuclear staining for Ki-67 was performed, and an average of 370 cells were positive per 1000 counted cells. Two months postoperatively, the surgical site was filled with flat fibrovascular and pigmented tissue, while the surrounding cornea was transparent with no superficial vascularization around the fibrotic scar. Thirty-two months after treatment, no recurrence of the neoplasia was reported.
© 2013 American College of Veterinary Ophthalmologists.
Publication Date: 2013-08-01 PubMed ID: 23905672DOI: 10.1111/vop.12084Google Scholar: Lookup
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Summary
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The research outlines a successful treatment of a horse with a mass tumor in its eye. The tumor was identified as a densely packed growth of abnormal cells, was surgically removed, and showed no sign of recurrence over two and a half years after the procedure.
Tumor Identification
- A three-year-old horse was presented with visible symptoms of a tumor growing in its right eye.
- The tumor appeared as a red mass emerging from behind the eyelid and seemed to originate in the bordering area between the cornea and the white of the eye, spreading extensively into the cornea.
- At the time of presentation, no other abnormalities, either in the eyes or throughout the horse’s system, were detectable.
Tumor Treatment
- The tumor was surgically removed via a procedure known as a lamellar keratectomy. This operation involves peeling away the affected layers of the cornea to excise the tumor.
- A laser therapy was also used in the surgery to treat the exposed area left by the removal of the tumor, as well as its surrounding areas.
Post-surgery Observations
- The removed tumor tissue was examined under a microscope (histopathological evaluation), and results showed it was made up of densely packed abnormal cells (mast cells), separated by fibrous tissue.
- The preparations were stained to detect Ki67, a protein in the cell nucleus often used as a marker for proliferation. On average, 370 of the 1000 counted cells were positive for Ki67, suggesting a high rate of division among mast cells.
- Two months after surgery, the wound had healed with no excessive capillary growth on the cornea surface. The cornea was clear, with no visible superficial vascularization around the scar.
- For this particular case, there was no recurrence of the tumor 32 months (almost 3 years) post-treatment
Cite This Article
APA
Halse S, Pizzirani S, Parry NM, Burgess KE.
(2013).
Mast cell tumor invading the cornea in a horse.
Vet Ophthalmol, 17(3), 221-227.
https://doi.org/10.1111/vop.12084 Publication
Researcher Affiliations
- Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA, 01536, USA.
MeSH Terms
- Animals
- Eye Neoplasms / pathology
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Horse Diseases / pathology
- Horse Diseases / surgery
- Horses
- Mastocytoma / pathology
- Mastocytoma / surgery
- Mastocytoma / veterinary
Citations
This article has been cited 1 times.- Flores AR, Azinhaga A, Pais E, Faria F, Nunes F, Gartner F, Amorim I. Equine ocular mast cell tumor: histopathological and immunohistochemical description. J Equine Sci 2017;28(4):149-152.
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