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Maternal and neonatal evaluation of derivated reactive oxygen metabolites (d-ROMs) and biological antioxidant potential in the horse.
Abstract: The aim of the present work was to evaluate derivated reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) in mares and foals to study perinatal oxidative status. A total of 60 animals were included in the present study. Maternal and foal venous blood samples were collected immediately after delivery along with a sample drawn from one of the umbilical arteries, and plasma samples were evaluated for lactatemia, d-ROMs, and BAP. The t test for unpaired data was applied between mares versus umbilical artery blood versus foals, both for d-ROMs and BAP. The Pearson test with two-tailed P value and a confidence interval of 95% was performed between d-ROMs and BAP and between d-ROMs and lactatemia, both for mares and foals. Finally, the t test for unpaired data was performed between fillies and colts. The t test showed differences between mares versus their own foals versus umbilical artery blood but not foals versus. umbilical artery blood, both for d-ROMs and BAP. A positive correlation was found both in mares and foals between BAP and d-ROMs and in mares between lactatemia and d-ROM. No differences in gender were found in BAP concentration. Our data are in line to previous studies performed in women and cattle.
Publication Date: 2014-12-03 PubMed ID: 25447151DOI: 10.1016/j.theriogenology.2014.07.041Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research article focuses on evaluating the levels of derivative reactive oxygen metabolites (d-ROMs) and Biological Antioxidant Potential (BAP) in mares and foals right after birth. The aim of the study is to learn more about how antioxidant activity might affect maternal and neonatal health in horses, and whether these measures are different in male and female foals.
Study Design
- The research was conducted on 60 horses in total, this included both mares (mothers) and their foals (newborns).
- Blood samples were taken from the mares and foals right after birth, as well as from one of the umbilical arteries. The aim was studying oxidative status symbolised by the levels of lactatemia, d-ROMs, and BAP.
- Statistical tests were applied to compare the levels of d-ROMs and BAP between the mares, their foals, and the umbilical artery blood. The tests were also designed to look for correlations between these measurements, and whether these relationships varied between mares and foals.
Results
- Statistical tests revealed differences between mares and their own foals, and the umbilical artery blood in terms of both d-ROMs and BAP levels. However, no differences were found between the foals and the umbilical artery blood.
- A positive correlation was observed between the BAP and d-ROMs in both mares and foals. In mares, there was also a correlation between lactatemia and d-ROMs, suggesting these two terms might be connected.
- No difference was found in BAP concentration between male and female foals, suggesting that gender does not have an impact on the Biological Antioxidant Potential.
Conclusion
- The results of the study are in line with previous research on human women and female cattle, suggesting similar biological processes might be at work in all three species as regards the roles of BAP and d-ROMs.
- Despite the differences found between the mares and their foals, the researchers did not find any gender-based disparities in BAP levels among the foals.
Cite This Article
APA
Sgorbini M, Bonelli F, Marmorini P, Biagi G, Corazza M, Pasquini A.
(2014).
Maternal and neonatal evaluation of derivated reactive oxygen metabolites (d-ROMs) and biological antioxidant potential in the horse.
Theriogenology, 83(1), 48-51.
https://doi.org/10.1016/j.theriogenology.2014.07.041 Publication
Researcher Affiliations
- Department of Veterinary Sciences, University of Pisa, Pisa, Italy.
MeSH Terms
- Animals
- Animals, Newborn
- Antioxidants / metabolism
- Female
- Fetal Blood / chemistry
- Horses / metabolism
- Male
- Oxidative Stress / physiology
- Oxygen / metabolism
- Pregnancy
- Reactive Oxygen Species / metabolism
Citations
This article has been cited 6 times.- Taylor SD, Serpa PBS, Santos AP, Hart KA, Vaughn SA, Moore GE, Mukhopadhyay A, Page AE. Effects of intravenous administration of peripheral blood-derived mesenchymal stromal cells after infusion of lipopolysaccharide in horses. J Vet Intern Med 2022 Jul;36(4):1491-1501.
- Sgorbini M, Bonelli F, Percacini G, Pasquini A, Rota A. Maternal and Neonatal Evaluation of Derived Reactive Oxygen Metabolites and Biological Antioxidant Potential in Donkey Mares and Foals. Animals (Basel) 2021 Oct 3;11(10).
- Shono S, Gin A, Minowa F, Okubo K, Mochizuki M. The Oxidative Stress Markers of Horses-the Comparison with Other Animals and the Influence of Exercise and Disease. Animals (Basel) 2020 Apr 3;10(4).
- Del Prete C, Vastolo A, Pasolini MP, Cocchia N, Montano C, Cutrignelli MI. Effects of maternal dietary supplementation with antioxidants on clinical status of mares and their foal. BMC Vet Res 2024 Sep 11;20(1):404.
- Riccio AV, Costa BK, Alonso MA, Affonso FJ, França DS, Nichi M, Belli CB, McLean AK, Boakari YL, Fernandes CB. Comparative Assessment of Oxidative and Antioxidant Parameters in Mule and Horse Neonates during Their First Month of Extrauterine Adaptation. Animals (Basel) 2023 Dec 16;13(24).
- Taylor SD, Hart KA, Vaughn S, Giancola SC, Serpa PBS, Santos AP. Effects of intravenous administration of ascorbic acid (vitamin C) on oxidative status in healthy adult horses. J Vet Intern Med 2024 Jan-Feb;38(1):460-468.
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