Measurement of pulmonary diffusing capacity for carbon monoxide and functional residual capacity during rebreathing in conscious thoroughbreds.
Abstract: A rebreathing method for measurement of pulmonary diffusing capacity for carbon monoxide (DLCO) and functional residual capacity (FRC) was evaluated in conscious horses. Horses were manually ventilated through an endotracheal tube, using a custom-made syringe filled with a gas mixture containing 18-carbon monoxide (18CO) and helium (He). The 18CO and He concentrations were continuously monitored by use of a mass spectrometer connected to the rebreathing circuit. Values for DLCO and FRC were calculated from changes in the concentration of these 2 gases. In 11 Thoroughbreds, mean (+/- SD) DLCO was 330.3 +/- 56.9 ml.min-1 x mm of Hg-1, and FRC was 20.21 +/- 3.35 L. Body weight normalization yielded mean (+/- SD) values of 0.652 +/- 0.114 ml.min-1 x mm of Hg-1 x kg-1 for DLCO, and 39.9 +/- 6.4 ml.kg-1 for FRC.
Publication Date: 1993-10-01 PubMed ID: 8250403
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Animal Health
- Body Weight
- Clinical Findings
- Clinical Study
- Comparative Study
- Diagnosis
- Diagnostic Technique
- Disease Diagnosis
- Equine Diseases
- Equine Health
- Horses
- In Vivo
- Laboratory Methods
- Physiology
- Pulmonary Health
- Respiratory Health
- Thoroughbreds
- Veterinary Care
- Veterinary Medicine
- Veterinary Procedure
- Veterinary Research
Summary
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The study details a method for measuring the pulmonary diffusing capacity for carbon monoxide (DLCO) and functional residual capacity (FRC) in horses using a rebreathing approach that involves manual ventilation with a customized gas mixture. Using this technique, researchers calculated average DLCO and FRC values based on variations in monitored gas concentrations.
Research Approach
- An experimental method was developed to evaluate the pulmonary variables—DLCO and FRC—in conscious horses.
- In this context, DLCO refers to the ability of the horse’s lung to transfer gas from inhaled air into the bloodstream and it is vital for proper respiratory function.
- FRC, on the other hand, refers to the volume of gas that remains in the lungs after a normal exhalation. This residual gas plays a crucial role in preventing the lungs from collapsing.
- Eleven thoroughbred horses were selected for the study.
Idea and Implementation
- The researchers used a gas mixture containing 18-carbon monoxide (18CO) and helium (He) to manually ventilate the horses via an endotracheal tube.
- A custom-made syringe was used to manage the gas administration.
- The concentrations of 18CO and He in the rebreathing circuit were continuously observed using a mass spectrometer.
Results Interpretation
- The researchers used the changes in the concentrations of the two gases to calculate the values for DLCO and FRC.
- The average DLCO in the eleven horses was found to be 330.3 +/- 56.9 ml.min-1 x mm of Hg-1.
- Meanwhile, the average FRC was measured at 20.21 +/- 3.35 L.
- The values were normalized according to the horses’ body weight which resulted in mean values of 0.652 +/- 0.114 ml.min-1 x mm of Hg-1 x kg-1 for DLCO, and 39.9 +/- 6.4 ml.kg-1 for FRC.
Implications
- This study presents a useful method for the measurement of lung function parameters in conscious horses.
- Having accurate readings of DLCO and FRC can help in the medical assessment, diagnosis, and treatment of various equine respiratory disorders.
Cite This Article
APA
Aguilera-Tejéro E, Pascoe JR, Amis TC, Kurpershoek CJ, Woliner MJ.
(1993).
Measurement of pulmonary diffusing capacity for carbon monoxide and functional residual capacity during rebreathing in conscious thoroughbreds.
Am J Vet Res, 54(10), 1752-1757.
Publication
Researcher Affiliations
- Department of Surgery, School of Veterinary Medicine, University of California-Davis 95616.
MeSH Terms
- Animals
- Carbon Monoxide
- Functional Residual Capacity / physiology
- Horses / physiology
- Male
- Models, Biological
- Pulmonary Diffusing Capacity / physiology
Citations
This article has been cited 2 times.- Dane DM, Cao K, Lu H, Yilmaz C, Dolan J, Thaler CD, Ravikumar P, Hammond KA, Hsia CCW. Acclimatization of low altitude-bred deer mice ( Peromyscus maniculatus) to high altitude. J Appl Physiol (1985) 2018 Nov 1;125(5):1411-1423.
- Yilmaz C, Ravikumar P, Bellotto DJ, Unger RH, Hsia CC. Fatty diabetic lung: functional impairment in a model of metabolic syndrome. J Appl Physiol (1985) 2010 Dec;109(6):1913-9.
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