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Home / Equine Research Bank / Can J Vet Res / Metoclopramide ameliorates the effects of endotoxin on gastr...
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire1999; 63(1); 37-40;

Metoclopramide ameliorates the effects of endotoxin on gastric emptying of acetaminophen in horses.

Abstract: The effect of metoclopramide on gastric emptying of a liquid marker in horses was evaluated by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal, fasted horses (n = 7), horses given endotoxin intravenously (n = 7), and horses given intravenous metoclopramide plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration vs time curve (AUC) were compared among treatment groups. Endotoxin caused a profound delay in gastric emptying, and pretreatment with metoclopramide significantly (P < 0.05) ameliorated this effect.
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Publication Date: 1999-01-26 PubMed ID: 9918332PubMed Central: PMC1189513
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study examines how metoclopramide, a drug often used to treat digestive issues, can improve the effects of endotoxins on the speed at which horses’ stomachs empty acetaminophen.

Overview of the Study

  • The researchers aimed to investigate the impact of metoclopramide, a gastrointestinal medication, on gastric emptying (the process wherein the stomach empties its contents into the small intestine) when horses are exposed to endotoxins.
  • Endotoxins are harmful substances that are released when certain bacteria die and break apart. They can cause a broad variety of symptoms, including a decline in the rate of gastric emptying.
  • The focus of the study was to understand whether metoclopramide can help enhance the rate of gastric emptying, particularly in the presence of endotoxin, using acetaminophen as a marker to measure gastric emptying.

Methodology

  • Three groups of horses were used in the experiment: normal, fasted horses, horses given endotoxin intravenously, and horses given both intravenous metoclopramide and endotoxin.
  • The researchers measured gastric emptying by analyzing serum concentrations of acetaminophen, a medication commonly used for pain relief and reducing fever. When taken orally, the rate at which acetaminophen can be detected in the blood through serum concentration serves as a good indicator of gastric emptying.
  • Key parameters, including the time to reach peak serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration vs. time curve (AUC), were compared among the treatment groups.

Findings

  • The study found that the introduction of endotoxin deeply delayed gastric emptying. This illustrates the harmful effects of endotoxin on the digestive process.
  • However, the researchers observed that when metoclopramide was given to horses prior to the endotoxin, it notably ameliorated these effects. The horses that received metoclopramide demonstrated a quicker rate of gastric emptying compared to those that were only given endotoxin.
  • This suggests that metoclopramide could potentially be used as an effective intervention to combat the impediment in gastric emptying caused by endotoxins in horses.

Cite This Article

APA
Doherty TJ, Andrews FM, Abraha TW, Osborne D, Frazier DL. (1999). Metoclopramide ameliorates the effects of endotoxin on gastric emptying of acetaminophen in horses. Can J Vet Res, 63(1), 37-40.

Publication

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
ISSN: 0830-9000
NlmUniqueID: 8607793
Country: Canada
Language: English
Volume: 63
Issue: 1
Pages: 37-40

Researcher Affiliations

Doherty, T J
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA. Doherty.Tom@Hospital.Vet.UTK.edu
Andrews, F M
    Abraha, T W
      Osborne, D
        Frazier, D L

          MeSH Terms

          • Acetaminophen / blood
          • Acetaminophen / pharmacokinetics
          • Animals
          • Anti-Inflammatory Agents, Non-Steroidal / blood
          • Area Under Curve
          • Biomarkers
          • Dopamine Antagonists / pharmacology
          • Endotoxins / pharmacology
          • Female
          • Gastric Emptying / drug effects
          • Horses / physiology
          • Metoclopramide / pharmacology

          References

          This article includes 15 references
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          Citations

          This article has been cited 3 times.
          1. Marzok M, Kandeel M, Alkhodair K, Abdel-Raheem S, Ismail H, Farag A, Ibrahim H, El-Ashkar M, Shousha S, El-Khodery S. Evaluation of cardiac indices using M-mode echocardiography after administration of metoclopramide and ondansetron in donkeys (Equus asinus): an experimental study.. Front Vet Sci 2023;10:1189710.
            doi: 10.3389/fvets.2023.1189710pubmed: 37680391google scholar: lookup
          2. Koenig J, Cote N. Equine gastrointestinal motility--ileus and pharmacological modification.. Can Vet J 2006 Jun;47(6):551-9.
            pubmed: 16808227
          3. Meisler SD, Doherty TJ, Andrews FM, Osborne D, Frazier DL. Yohimbine ameliorates the effects of endotoxin on gastric emptying of the liquid marker acetaminophen in horses.. Can J Vet Res 2000 Oct;64(4):208-11.
            pubmed: 11041497
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