Mitomycin C, with or without surgery, for the treatment of ocular squamous cell carcinoma in horses.
Abstract: Ocular lesions in horses, confirmed as squamous cell carcinoma, were treated topically with mitomycin C. Fourteen horses with confirmed ocular squamous cell carcinoma, three of which were affected bilaterally, were included in the study. Eight of the affected eyes were treated topically with mitomycin C alone; in the other nine eyes, the tumours were surgically removed and topical treatment with mitomycin C was then applied. The treatment protocol consisted of 0.2 ml of 0.04 per cent mitomycin C instilled into the conjunctival sac of the affected eye, every six hours, in rounds of seven days of treatment followed by seven days without treatment. This was repeated until full regression of the tumour occurred (up to four rounds of treatment with mitomycin C). Of the eight eyes treated with mitomycin C alone (without surgery), clinical resolution occurred in six cases. Of the nine eyes treated with a combination of surgery and topical mitomycin C, clinical resolution occurred in seven cases. No complications were observed.
Publication Date: 2010-09-08 PubMed ID: 20817898DOI: 10.1136/vr.c3815Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
Summary
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The research paper reports on the use of mitomycin C, with or without surgery, to treat squamous cell carcinoma in horses’ eyes. The results indicate a positive outcome when using this treatment approach.
Research Subject and Methodology
- The study centred around fourteen horses confirmed to have ocular squamous cell carcinoma, a common type of eye cancer in horses. It’s important to note that three of these horses were impacted in both eyes.
- A total of seventeen affected eyes were treated either by mitomycin C alone or in combination with surgery. Specifically, eight eyes received topical treatment of mitomycin C only, while nine eyes underwent surgery to remove the tumours followed by mitomycin C application.
Treatment Protocol
- The treatment protocol involved topically applying 0.2 ml of 0.04 per cent mitomycin C onto the conjunctival sac of the afflicted eye. This was performed every six hours.
- The treatment was given in rounds of seven continuous days, followed by an equal period without treatment. This schedule was maintained until the cancerous growth completely regressed.
- The maximum number of treatment rounds per horse was limited to four.
Findings
- Out of eight eyes that underwent treatment with mitomycin C alone, six reported clinical resolution, indicating the significant efficacy of mitomycin C in treating ocular squamous cell carcinoma.
- When mitomycin C application was combined with surgery, higher effectiveness was observed. Seventy-eight percent of the treated eyes (seven out of nine) reported clinical resolution.
- Remarkably, no associated complications surfaced during or following the treatment. This further emphasises the viability of this approach in treating ocular squamous cell carcinoma in horses.
The findings hint towards the potential of a non-invasive approach, i.e., the use of mitomycin C alone, to treat ocular squamous cell carcinoma in horses effectively. Furthermore, the combination of surgery and mitomycin C treatment seems highly effective and safe. Further studies, with a larger sample size, might provide more insight into the applicability of these findings.
Cite This Article
APA
Malalana F, Knottenbelt D, McKane S.
(2010).
Mitomycin C, with or without surgery, for the treatment of ocular squamous cell carcinoma in horses.
Vet Rec, 167(10), 373-376.
https://doi.org/10.1136/vr.c3815 Publication
Researcher Affiliations
- Philip Leverhulme Equine Hospital, University of Liverpool, Leahurst, Chester High Road, Neston, Cheshire. fernmala@liverpool.ac.uk
MeSH Terms
- Animals
- Antibiotics, Antineoplastic / therapeutic use
- Carcinoma, Squamous Cell / drug therapy
- Carcinoma, Squamous Cell / surgery
- Carcinoma, Squamous Cell / veterinary
- Dose-Response Relationship, Drug
- Eye Neoplasms / drug therapy
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Horse Diseases / drug therapy
- Horse Diseases / surgery
- Horses
- Male
- Mitomycin / therapeutic use
- Treatment Outcome
Citations
This article has been cited 3 times.- Delgado EC. Topical chemotherapy with mitomycin C in a feline corneal squamous cell carcinoma. JFMS Open Rep 2020 Jan-Jun;6(1):2055116920917833.
- Jeanes EC, Koll-Hampp S, Dawson C, Dunkel B, Tetas Pont R. Rhomboid blepharoplasty and cryotherapy for the treatment of a squamous cell carcinoma on the lower eyelid in a horse. Clin Case Rep 2019 Jan;7(1):40-46.
- Beermann A, Clottu O, Reif M, Biegel U, Unger L, Koch C. A randomized placebo-controlled double-blinded study comparing oral and subcutaneous administration of mistletoe extract for the treatment of equine sarcoid disease. J Vet Intern Med 2024 May-Jun;38(3):1815-1824.
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