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Home / Equine Research Bank / Chromosome Res / Multidirectional cross-species painting illuminates the hist...
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2008; 16(1); 89-107; doi: 10.1007/s10577-007-1201-7

Multidirectional cross-species painting illuminates the history of karyotypic evolution in Perissodactyla.

Abstract: The order Perissodactyla, the group of odd-toed ungulates, includes three extant families: Equidae, Tapiridae, and Rhinocerotidae. The extremely rapid karyotypic diversification in perissodactyls has so far prevented the establishment of genome-wide homology maps between these three families by traditional cytogenetic approaches. Here we report the first genome-wide comparative chromosome maps of African rhinoceroses, four tapir species, four equine species, and humans. These maps were established by multidirectional chromosome painting, with paint probes derived from flow-sorted chromosomes of Equus grevyi, Tapirus indicus, and Ceratotherium simum as well as painting probes from horse and human. The Malayan tapir (Tapirus indicus), Baird's tapir (T. bairdii), mountain tapir (T. pinchaque), lowland tapir (T. terrestris), and onager (E. hemionus onager), were studied by cross-species chromosome painting for the first time. Our results, when integrated with previously published comparative chromosome maps of the other perissodactyl species, have enabled the reconstruction of perissodactyl, ceratomorph, and equid ancestral karyotypes, and the identification of the defining evolutionary chromosomal rearrangements along each lineage. Our results allow a more reliable estimate of the mode and tempo of evolutionary chromosomal rearrangements, revealing a striking switch between the slowly evolving ceratomorphs and extremely rapidly evolving equids.
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Publication Date: 2008-02-23 PubMed ID: 18293107DOI: 10.1007/s10577-007-1201-7Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the establishment of the first genome-wide comparative chromosome maps for the order Perissodactyla (odd-toed ungulates) which includes the Equidae, Tapiridae, and Rhinocerotidae families. Through the use of multidirectional chromosome painting, they have determined the ancestral karyotypes and defining evolutionary chromosomal rearrangements of these species, highlighting a switch in the rate of evolution between slowly evolving ceratomorphs and rapidly evolving equids.

Research Objective and Approach

  • Researchers embarked on a study to create the first genome-wide comparative chromosome maps for the Perissodactyla order (odd-toed ungulates). This order includes extant families such as Equidae (horses, donkeys, zebras), Tapiridae (tapirs), and Rhinocerotidae (rhinoceroses).
  • The traditional cytogenetic approach had fallen short in establishing genome-wide homology maps due to the fast pace of karyotypic diversification in perissodactyls.
  • The maps in the current research were created using a process known as multidirectional chromosome painting with paint probes derived from the chromosomes of species within these families as well as horse and human.

Species Studied and Methodology

  • The species included in the study for the first time were four tapir species—Malayan tapir, Baird’s tapir, mountain tapir, lowland tapir, one equine species, the onager, and African rhinoceroses.
  • These species were studied using cross-species chromosome painting, a method that allows the identification of homologous segments among different species.

Findings and Implications

  • The findings from this research combined with previously published comparative chromosome maps allowed the reconstruction of ancestral karyotypes for perissodactyl, ceratomorph, and equid lineages as well as the identification of defining evolutionary chromosomal rearrangements in each lineage.
  • Through these maps, the researchers were able to identify a striking switch between the slowly evolving ceratomorphs and the rapidly evolving equids.
  • These results can facilitate a more accurate estimation of the mode and tempo of evolutionary chromosomal rearrangements in these species, contributing significantly to our understanding of their evolutionary history.

Cite This Article

APA
Trifonov VA, Stanyon R, Nesterenko AI, Fu B, Perelman PL, O'Brien PC, Stone G, Rubtsova NV, Houck ML, Robinson TJ, Ferguson-Smith MA, Dobigny G, Graphodatsky AS, Yang F. (2008). Multidirectional cross-species painting illuminates the history of karyotypic evolution in Perissodactyla. Chromosome Res, 16(1), 89-107. https://doi.org/10.1007/s10577-007-1201-7

Publication

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
ISSN: 0967-3849
NlmUniqueID: 9313452
Country: Netherlands
Language: English
Volume: 16
Issue: 1
Pages: 89-107

Researcher Affiliations

Trifonov, Vladimir A
  • Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090, Russia. vlad@bionet.nsc.ru
Stanyon, Roscoe
    Nesterenko, Anastasia I
      Fu, Beiyuan
        Perelman, Polina L
          O'Brien, Patricia C M
            Stone, Gary
              Rubtsova, Nadezhda V
                Houck, Marlys L
                  Robinson, Terence J
                    Ferguson-Smith, Malcolm A
                      Dobigny, Gauthier
                        Graphodatsky, Alexander S
                          Yang, Fengtang

                            MeSH Terms

                            • Animals
                            • Chromosome Painting
                            • Chromosomes, Mammalian / genetics
                            • Equidae / genetics
                            • Evolution, Molecular
                            • Humans
                            • Karyotyping
                            • Molecular Probes
                            • Perissodactyla / genetics
                            • Phylogeny
                            • Species Specificity

                            Grant Funding

                            • Wellcome Trust

                            References

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