Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Abstract: Borna Disease Virus (BDV) is a neurotropic RNA virus that is worldwide in distribution, causing movement and behavior disorders in a wide range of animal species. BDV has also been reported to be associated with neuropsychiatric diseases of humans by serologic study and by recovery of nucleic acid or virus from blood or brain. Natural infections of horses and sheep produce encephalitis with erratic excited behaviors, hyperkinetic movement or gait abnormalities; naturally infected cats have ataxic "staggering disease." Experimentally infected primates develop hyperactivity, aggression, disinhibition, then apathy; prosimians (lower primates) have hyperactivity, circadian disruption, abnormal social and dominance behaviors, and postural disorders. However, the neuropharmacological determinants of BD phenotypes in laboratory and natural hosts are incompletely understood. Here we review how experimentally infected rodents have provided models for examining behavioral, pharmacologic, and biochemical responses to viral challenge, and how rodents experimentally infected as neonates or as adolescents are providing models for examining age-specific neuropharmacological adaptations to viral injury.
Publication Date: 2003-04-02 PubMed ID: 12667891DOI: 10.1016/s0091-3057(03)00019-4Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
- Review
Summary
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The research article explores the effects of Borna Disease Virus (BDV), a worldwide neurotropic RNA virus, which induces behavior disturbances and movement disorders in various animal species and is indicated to be connected to neuropsychiatric diseases in humans. The study uses experimentally infected rodents to help understand age-specific behavioral, biochemical, and pharmacological responses to viral infection.
Overview of Borna Disease Virus (BDV)
- BDV is a neurotropic RNA virus with a global distribution linked to behavioral disorders and movement discrepancies in numerous animal species.
- This virus has also been associated with neuropsychiatric diseases in humans, as indicated by serological studies and virus detection in blood or brain samples.
Effects of BDV in Different Animals
- Natural BDV infections in horses and sheep often result in encephalitis, hyperkinetic movement, irregular excitable behaviors, or gait abnormalities.
- Infected cats exhibit ataxic “staggering disease.”
- In experimental settings, primates infected with BDV showed a wide array of symptoms, including aggression, hyperactivity, disinhibition, and later apathy. Lower primates (prosimians) displayed signs of hyperactivity, abnormal social and dominance behaviors, disturbed circadian rhythms, and postural disorders.
Neuropharmacological Determinants of BD Phenotypes
- The study acknowledges that the neuropharmacological components leading to BD phenotypes in both natural and laboratory hosts are yet to be fully understood.
Use of Rodent Models in Understanding BDV
- The paper emphasizes the usefulness of experimentally infected rodents in studying the behavioral, pharmacological, and biochemical responses to BDV.
- Rodents infected as neonates or adolescents offer insight on the age-specific neuropharmacological adaptations to viral injury. These models represent potentially valuable tools for gaining further understanding of the correlation between BDV infection and associated behavioral disorders.
Cite This Article
APA
Solbrig MV, Koob GF.
(2003).
Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus.
Pharmacol Biochem Behav, 74(4), 777-787.
https://doi.org/10.1016/s0091-3057(03)00019-4 Publication
Researcher Affiliations
- Department of Neurology and Pharmacology, University of California at Irvine, 3107 Gillespie Neuroscience Research Building, Irvine, CA 92697-4292, USA. msolbrig@uci.edu
MeSH Terms
- Animals
- Borna Disease / chemically induced
- Borna Disease / drug therapy
- Borna Disease / physiopathology
- Borna Disease / virology
- Borna disease virus / pathogenicity
- Central Nervous System Viral Diseases / chemically induced
- Central Nervous System Viral Diseases / drug therapy
- Central Nervous System Viral Diseases / physiopathology
- Central Nervous System Viral Diseases / virology
- Disease Models, Animal
- Humans
Grant Funding
- DA00076 / NIDA NIH HHS
- DA13332 / NIDA NIH HHS
References
This article includes 110 references
Citations
This article has been cited 7 times.- Lourbopoulos A, Schnurbus L, Guenther R, Steinlein S, Ruf V, Herms J, Jahn K, Huge V. Case report: Fatal Borna virus encephalitis manifesting with basal brain and brainstem symptoms. Front Neurol 2023;14:1305748.
- Huang R, Gao H, Zhang L, Jia J, Liu X, Zheng P, Ma L, Li W, Deng J, Wang X, Yang L, Wang M, Xie P. Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells. PLoS One 2012;7(9):e44665.
- Chauhan VS, Kluttz JM, Bost KL, Marriott I. Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitis. J Immunol 2011 Jun 15;186(12):7255-63.
- Rackova S, Janu L, Kabickova H. Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis. BMC Psychiatry 2010 Sep 8;10:70.
- Solbrig MV. Animal models of CNS viral disease: examples from borna disease virus models. Interdiscip Perspect Infect Dis 2010;2010:709791.
- Chauhan VS, Sterka DG Jr, Furr SR, Young AB, Marriott I. NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens. Glia 2009 Mar;57(4):414-23.
- Solbrig MV, Hermanowicz N. Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats. J Neurovirol 2008 May;14(3):252-60.
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