New antimicrobials, systemic distribution, and local methods of antimicrobial delivery in horses.
Abstract: The local delivery of antimicrobials is a valuable therapeutic tool with a low morbidity, is practical to use, and is well tolerated by horses. Clinically, its use has allowed equine practitioners to achieve better results when treating musculoskeletal infections, and it represents an extremely useful tool in the practitioner's armamentarium against these types of infections. The technique is indicated to combat orthopedic infections involving bones, joints, physes, tendon sheaths, and foot tissues. Optimal treatment must include other approaches, such as systemic antimicrobial therapy and surgical debridement and lavage, and monitoring of the clinical progression of the patient can help to determine the ideal protocol for each patient.
Publication Date: 2006-08-03 PubMed ID: 16882477DOI: 10.1016/j.cveq.2006.03.006Google Scholar: Lookup
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Summary
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This research paper discusses the benefits of local antimicrobial delivery in horses for the treatment of musculoskeletal infections, indicating that such method is practical, has low morbidity and is well received by horses.
Benefits of Local Antimicrobial Delivery
- The paper highlights local delivery of antimicrobials as a valuable therapeutic tool in equine treatment, specifically due to its low level of morbidity, making it a safer option compared to some other treatments.
- It is also cited for its practicality in usage which might be ideal in conditions where horses may not tolerate other more invasive or extensive methods of treatment.
- The method seems to be well tolerated by horses, an aspect that might impact recovery time and overall improvement in health
Clinical Applications
- Local antimicrobial delivery has shown promising results in treating musculoskeletal infections in horses. Such infections often involve bones, joints, and foot tissues, and are challenging to treat effectively.
- The authors emphasize that the method is now a useful tool for veterinary practitioners in battling such complex infections, thus improving the overall efficacy of equine treatment strategies.
Combination with Other Treatment Approaches
- While advocating for local antimicrobials, the research does underscore the importance of a comprehensive treatment approach. This recommendation suggests that best results can be achieved when the local delivery of antimicrobial is combined with other routine treatment strategies.
- Such routines often include systemic antimicrobial therapy, surgical debridement, and lavage. Supporting this assertion, the authors maintain that monitoring the clinical progression of the patient can lead to a more tailored and effective treatment plan.
Cite This Article
APA
Cruz AM, Rubio-Martinez L, Dowling T.
(2006).
New antimicrobials, systemic distribution, and local methods of antimicrobial delivery in horses.
Vet Clin North Am Equine Pract, 22(2), 297-viii.
https://doi.org/10.1016/j.cveq.2006.03.006 Publication
Researcher Affiliations
- Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1. acruz@uoguelph.ca
MeSH Terms
- Absorbable Implants / veterinary
- Animals
- Anti-Infective Agents / administration & dosage
- Anti-Infective Agents / pharmacokinetics
- Drug Delivery Systems / veterinary
- Drug Implants / administration & dosage
- Horse Diseases / drug therapy
- Horses
- Infusion Pumps / veterinary
- Injections, Intra-Articular / veterinary
- Perfusion / veterinary
Citations
This article has been cited 9 times.- Mizuguchi Y, Kato A, Aizu M. Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis. J Vet Med Sci 2023 Jan 6;85(1):55-61.
- Bonilla AG, Causeret L, Torrent-Crosa A. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses. Can Vet J 2021 Sep;62(9):975-981.
- Gustafsson K, Tatz AJ, Dahan R, Abu Ahmad W, Britzi M, Sutton GA, Kelmer G. Synovial Concentration of Trimethoprim-Sulphadiazine Following Regional Limb Perfusion in Standing Horses. Animals (Basel) 2021 Jul 13;11(7).
- Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases. Animals (Basel) 2021 Jan 19;11(1).
- Merkatoris P, Schleining J, Krull A, Borts D, Fajt V. In vitro Elution of Penicillin, Ampicillin, Tetracycline, Tulathromycin, and Florfenicol From Plaster of Paris Beads. Front Vet Sci 2020;7:585423.
- Nieto JE, Trela J, Stanley SD, Yamout S, Snyder JR. Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses. Can J Vet Res 2016 Jul;80(3):230-5.
- Hyde RM, Lynch TM, Clark CK, Slone DE, Hughes FE. The influence of perfusate volume on antimicrobial concentration in synovial fluid following intravenous regional limb perfusion in the standing horse. Can Vet J 2013 Apr;54(4):363-7.
- Delfosse V, El Warrak A, Clerfond P, Lussier B. Clinical investigation of local implantation of gentamicin-impregnated collagen sponges in dogs. Can Vet J 2011 Jun;52(6):627-30.
- Guillot M, Mespoulhes-Rivière C, Bousquet-Mélou A, Lacroix MZ, Roques BB, Lallemand EA. Pharmacokinetics, pharmacodynamics, and local tolerance at injection site of penicillin and gentamicin administered by intravenous regional limb perfusion in standing horses: comparison between weightbearing and flexed limbs. BMC Vet Res 2025 Nov 7;21(1):650.
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