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Nitrous oxide: effect on accumulation rate and uptake of bowel gases.
Abstract: Breathing 79% nitrous oxide (N2O) in oxygen increased the rate of accumulation of bowel gas during intraluminal bowel segment infusions of hydrogen, methane (CH4), air, or carbon dioxide (CO2) in four pentobarbital-anesthetized dogs more than did breathing 100% oxygen. A N2O-associated increase in the volume of naturally produced intestinal gas in five halothane-anesthetized ponies corroborated the findings in the dog studies. In a second group of four dogs a bolus of CH4 or CO2 was injected into the bowel lumen. When the dogs breathed O2 the bowel gas volume decreased. Gas was virtually absent in the CO2-containing segment within 20 minutes. Breathing N2O increased the volume of the segments containing CH4 while the CO2 segments decreased less rapidly than during O2 breathing. Breathing O2 after 30 minutes of N2O breathing caused little change in the rate of decrease in CO2 segment volumes. However, the CH4 segment volume ceased to increase and eventually returned toward control volumes.
Publication Date: 1979-09-01 PubMed ID: 573566DOI: 10.1213/00000539-197909000-00012Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research is about the impact of nitrous oxide on the accumulation and uptake of different gases in the bowel. It was found that nitrous oxide increases the rate of accumulation of bowel gas more than when only oxygen is breathed in.
Objective of the Research
The main aim of the research was to study the effects of nitrous oxide (N2O) on the accumulation and uptake of different types of bowel gases including hydrogen, methane (CH4), air, and carbon dioxide (CO2) in anesthetized dogs and ponies.
Methodology
- The research was conducted on two groups of dogs and one group of ponies.
- One group of dogs was made to breathe in a mixture of 79% nitrous oxide and oxygen during intraluminal bowel segment infusions of hydrogen, CH4, air, or CO2. The results were compared to those gathered when the dogs breathed 100% oxygen.
- Another group of dogs was given a bolus of CH4 or CO2 injected into their bowel lumen while they breathed either O2 or N2O.
- The volume changes in the bowel lumen segments filled with different gases were observed for the two groups of dogs under different breathing conditions.
- To corroborate the findings, similar studies were performed on halothane-anesthetized ponies as well.
Results
- Breathe in of Nitrous oxide increased the rate of accumulation of bowel gas compared to breathing 100% oxygen in the initial studies on dogs.
- In the second group of dogs, where a bolus of CH4 or CO2 was injected into the bowel lumen, a significant volume decrease was observed when the dogs breathed in O2. Particularly, gas was virtually absent in the CO2-containing segment within 20 minutes.
- Breathing in nitrous oxide increased the volume of the segments containing CH4, contrasting the effects of O2 breathing.
- However, in the case of the CO2 segments, the decrease in volume was less pronounced compared to when breathing O2.
- In the ponies, nitrous oxide resulted in an increased volume of naturally produced intestinal gas, substantiating the findings from the initial dog trials.
Conclusion
- The research concludes that nitrous oxide has a significant impact on the accumulation and absorption of bowel gases. Particularly, it boosts the accumulation rate of bowel gas during intraluminal bowel segment infusions of different gases compared to breathing in only oxygen.
Cite This Article
APA
Steffey EP, Johnson BH, Eger EI, Howland D.
(1979).
Nitrous oxide: effect on accumulation rate and uptake of bowel gases.
Anesth Analg, 58(5), 405-408.
https://doi.org/10.1213/00000539-197909000-00012 Publication
Researcher Affiliations
MeSH Terms
- Air
- Anesthesia, Inhalation
- Animals
- Carbon Dioxide / administration & dosage
- Dogs
- Gases
- Horses
- Hydrogen / administration & dosage
- Intestines / physiology
- Methane / administration & dosage
- Nitrous Oxide / administration & dosage
- Nitrous Oxide / pharmacology
- Oxygen
- Time Factors
Citations
This article has been cited 4 times.- Gupta N, Gupta A, Narayanan M R V. Current status of nitrous oxide use in pediatric patients. World J Clin Pediatr 2022 Mar 9;11(2):93-104.
- Boros M, Keppler F. Methane Production and Bioactivity-A Link to Oxido-Reductive Stress. Front Physiol 2019;10:1244.
- Katz I, Murdock J, Palgen M, Farjot G. A physiologically based model for denitrogenation kinetics. Med Gas Res 2017 Oct-Dec;7(4):256-259.
- Boulanger A, Hardy JF. [Intestinal distention during elective abdominal surgery: should nitrous oxide be banished?]. Can J Anaesth 1987 Jul;34(4):346-50.
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