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Home / Equine Research Bank / Can J Comp Med / Nonsteroidal anti-inflammatory drugs: a review. New applicat...
Canadian journal of comparative medicine : Revue canadienne de medecine comparee1977; 41(3); 233-240;

Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.

Abstract: Nonsteroidal anti-inflammatory drugs inhibit the biosynthesis of kinins and prostaglandins and stabilize leukocyte lysosomal membranes. Nonsteroidal anti-inflammatory drugs also weakly block the biosynthesis of histamine and serotonin, and pharmacologically antagonize kinins, prostaglandins and slow-reacting substance of anaphylaxis. Nonsteroidal anti-inflammatory drugs effectively control both cardiovascular and respiratory manifestations of hypersensitivity in cattle and horses. This, coupled with the contrasting lack of effectiveness of "antiamine" drugs, suggests that bio-amines such as histamine and serotonin (5-hydroxytryptamine) may be less important than kinins, postaglandins and slow-reacting substance in the mediation of the hypersensitivity/inflammatory reaction, at least in cardiopulmonary systems of these species. Nonsteroidal anti-inflammatory drugs justify more prominence in the clinical control of acute respiratory disease in domestic herbivores.
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Publication Date: 1977-07-01 PubMed ID: 332290PubMed Central: PMC1277585
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research looks into how nonsteroidal anti-inflammatory drugs (NSAIDs) can control hypersensitivity reactions in cattle and horses. The findings suggest these drugs might be more efficient at treating acute respiratory disease in domestic herbivores than previously thought.

Role of Nonsteroidal anti-inflammatory drugs

  • NSAIDs work by inhibiting the production of kinins and prostaglandins, compounds that are involved in inflammation. They also maintain the stability of leukocyte lysosomal membranes which play a critical role in an immune response.
  • In addition, NSAIDs have a mild inhibitory effect on the biosynthesis of histamine (involved in allergic responses) and serotonin, a key hormone that stabilizes our mood, feelings of well-being, and happiness.
  • Their pharmacological properties make them antagonists to kinins, prostaglandins, and the slow-reacting substance of anaphylaxis (a severe, potentially life-threatening allergic reaction).

Application and Effectiveness in Animals

  • The research found NSAIDs effectively manage cardiovascular and respiratory aspects of hypersensitivity in cattle and horses. Hypersensitivity refers to an exaggerated or inappropriate immune response to an antigen (substance that triggers an immune response).
  • This effectiveness, when compared to the ineffectiveness of “antiamine” drugs, indicates that perhaps bio-amines such as histamine and serotonin are less crucial than kinins, prostaglandins, and slow-reacting substances in these hypersensitivity or inflammatory reaction, at least in the cardiopulmonary systems of these animals.

Implication of Findings

  • The research suggests that NSAIDs deserve more recognition in the clinical treatment of acute respiratory disease in domestic herbivores. This means they might offer better strategies for managing such diseases in animals like cattle and horses, especially where current interventions aren’t working effectively.

Cite This Article

APA
Chand N, Eyre P. (1977). Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses. Can J Comp Med, 41(3), 233-240.

Publication

Canadian journal of comparative medicine : Revue canadienne de medecine comparee
ISSN: 0008-4050
NlmUniqueID: 0151747
Country: Canada
Language: English
Volume: 41
Issue: 3
Pages: 233-240

Researcher Affiliations

Chand, N
    Eyre, P

      MeSH Terms

      • Anaphylaxis / veterinary
      • Animals
      • Anti-Inflammatory Agents / pharmacology
      • Anti-Inflammatory Agents / therapeutic use
      • Arthritis / veterinary
      • Ascariasis / veterinary
      • Aspirin / therapeutic use
      • Cattle
      • Cattle Diseases / drug therapy
      • Diethylcarbamazine / therapeutic use
      • Guinea Pigs
      • Horse Diseases / drug therapy
      • Horses
      • Hypersensitivity / drug therapy
      • Hypersensitivity / veterinary
      • Indomethacin / therapeutic use
      • Inflammation
      • Kinins / antagonists & inhibitors
      • Leukocytes / enzymology
      • Meclofenamic Acid / therapeutic use
      • Phagocytosis
      • Phenylbutazone / therapeutic use
      • Pneumonia, Atypical Interstitial, of Cattle / drug therapy
      • Prostaglandin Antagonists / pharmacology
      • SRS-A / antagonists & inhibitors

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      Citations

      This article has been cited 4 times.
      1. Beck MR, Gregorini P. How Dietary Diversity Enhances Hedonic and Eudaimonic Well-Being in Grazing Ruminants. Front Vet Sci 2020;7:191.
        doi: 10.3389/fvets.2020.00191pubmed: 32373637google scholar: lookup
      2. Basile RC, Rivera GG, Del Rio LA, de Bonis TC, do Amaral GP, Giangrecco E, Ferraz G, Yoshinari NH, Canola PA, Queiroz Neto A. Anaphylactoid reaction caused by sodium ceftriaxone in two horses experimentally infected by Borrelia burgdorferi. BMC Vet Res 2015 Aug 12;11:197.
        doi: 10.1186/s12917-015-0478-6pubmed: 26265349google scholar: lookup
      3. Kothavade PS, Nagmoti DM, Bulani VD, Juvekar AR. Arzanol, a potent mPGES-1 inhibitor: novel anti-inflammatory agent. ScientificWorldJournal 2013;2013:986429.
        doi: 10.1155/2013/986429pubmed: 24198734google scholar: lookup
      4. Ruckebusch Y, Toutain PL. Nonsteroidal anti-inflammatory agents: species differences in pharmacodynamics. Vet Res Commun 1983 Dec;7(1-4):359-68.
        doi: 10.1007/BF02228646pubmed: 6364554google scholar: lookup
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