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Home / Equine Research Bank / Antibiotics (Basel) / Occurrence and Antimicrobial Susceptibility Profiles of Stre...
Antibiotics (Basel, Switzerland)2021; 11(1); doi: 10.3390/antibiotics11010025

Occurrence and Antimicrobial Susceptibility Profiles of Streptococcus equi subsp. zooepidemicus Strains Isolated from Mares with Fertility Problems.

Abstract: Streptococcus equi subsp. zooepidemicus (S. zooepidemicus), is a β-hemolytic Streptococcus belonging to the Lancefield group C; it is a rare human pathogen, but in horses, it is frequently associated with endometritis. This study aimed to isolate S. zooepidemicus strains, associated with bacterial endometritis in mares, and to define their antimicrobial resistance profile. Twenty-three isolates were recovered from one hundred ninety-six equine uterine swabs (11.7%). Bacterial identification was carried out by Api 20 Strep and confirmed by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS), while antimicrobial susceptibility testing was performed by disk diffusion method on Muller Hinton agar plates. The antibiotic resistance profiles of the isolates revealed a high percentage of resistance to amikacin (95.6%), ampicillin (73.9%) and tetracycline (69.6%), while ceftiofur and ceftriaxone were highly effective with 82.6% and 78.3% of the isolates inhibited, respectively. An intriguing value of resistance to penicillin (34.8%), which represents the first-choice antibiotic in equine S. zooepidemicus infections, was observed. Furthermore, a high prevalence of multidrug-resistant strains (82.6%) was recorded. Continuous surveillance of this potential zoonotic pathogen and an appropriate antimicrobial stewardship program with the promotion of correct use of antimicrobials, after a proper diagnosis, are needed to allow an effective therapy.
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Publication Date: 2021-12-27 PubMed ID: 35052902PubMed Central: PMC8773361DOI: 10.3390/antibiotics11010025Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study delves into the occurrence and antimicrobial resistance of Streptococcus equi subsp. zooepidemicus (S. zooepidemicus), a bacteria often linked to endometritis in horses. The research involved isolating this bacteria from equine uterine swabs and determining its susceptibility to various antibiotics. Key findings include high resistance to some antibiotics, with a significant amount being multidrug-resistant, and an unexpected level of resistance to penicillin, a commonly-used treatment.

Methodology

  • The research involved the analysis of 196 equine uterine swabs from which they succeeded in isolating 23 strains of S. zooepidemicus. This represents a recovery rate of 11.7%.
  • Bacterial identification process involved the use of an analytical profile index for Streptococcus (Api 20 Strep) and was confirmed via matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
  • Antimicrobial susceptibility was tested via the disk diffusion method on Muller Hinton agar plates.

Findings

  • The isolates demonstrated a high degree of resistance to several antibiotics. This includes a 95.6% resistance observed to amikacin, 73.9% to ampicillin, and 69.6% to tetracycline.
  • Ceftiofur and Ceftriaxone showed significant efficacy against the bacteria with 82.6% and 78.3% of the isolates being inhibited, respectively.
  • A surprising finding was the high level of resistance to penicillin (34.8%), a drug commonly used as a first resort for such infections.
  • The study also recorded a high proportion of multidrug-resistant strains of S. zooepidemicus (82.6%).

Implications and Recommendations

  • The findings underscore the importance of continual monitoring of the pathogen and responsible use of antimicrobials
  • The high occurrence of antimicrobial resistance, particularly multidrug resistance, means veterinary professionals should make informed treatment decisions after a proper diagnosis.
  • The promotion of appropriate antimicrobial stewardship programs will ensure effective treatment and help to stem the spread of resistance.

Cite This Article

APA
Nocera FP, D'Eletto E, Ambrosio M, Fiorito F, Pagnini U, De Martino L. (2021). Occurrence and Antimicrobial Susceptibility Profiles of Streptococcus equi subsp. zooepidemicus Strains Isolated from Mares with Fertility Problems. Antibiotics (Basel), 11(1). https://doi.org/10.3390/antibiotics11010025

Publication

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
NlmUniqueID: 101637404
Country: Switzerland
Language: English
Volume: 11
Issue: 1

Researcher Affiliations

Nocera, Francesca Paola
  • Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
D'Eletto, Elena
  • Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
Ambrosio, Monica
  • Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
Fiorito, Filomena
  • Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
Pagnini, Ugo
  • Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
De Martino, Luisa
  • Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
  • Task Force on Microbiome Studies, University of Naples "Federico II", Naples, 80137, Italy.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 53 references
  1. Frontoso R, De Carlo E, Pasolini MP, van der Meulen K, Pagnini U, Iovane G, De Martino L. Retrospective study of bacterial isolates and their antimicrobial susceptibilities in equine uteri during fertility problems.. Res Vet Sci 2008 Feb;84(1):1-6.
    doi: 10.1016/j.rvsc.2007.02.008pubmed: 17434193google scholar: lookup
  2. Chalker VJ, Brooks HW, Brownlie J. The association of Streptococcus equi subsp. zooepidemicus with canine infectious respiratory disease.. Vet Microbiol 2003 Aug 29;95(1-2):149-56.
    doi: 10.1016/S0378-1135(03)00155-Xpmc: PMC7117392pubmed: 12860084google scholar: lookup
  3. Pesavento PA, Hurley KF, Bannasch MJ, Artiushin S, Timoney JF. A clonal outbreak of acute fatal hemorrhagic pneumonia in intensively housed (shelter) dogs caused by Streptococcus equi subsp. zooepidemicus.. Vet Pathol 2008 Jan;45(1):51-3.
    doi: 10.1354/vp.45-1-51pubmed: 18192575google scholar: lookup
  4. Britton AP, Davies JL. Rhinitis and meningitis in two shelter cats caused by Streptococcus equi subspecies zooepidemicus.. J Comp Pathol 2010 Jul;143(1):70-4.
    doi: 10.1016/j.jcpa.2009.12.007pmc: PMC7094740pubmed: 20106485google scholar: lookup
  5. Blum S, Elad D, Zukin N, Lysnyansky I, Weisblith L, Perl S, Netanel O, David D. Outbreak of Streptococcus equi subsp. zooepidemicus infections in cats.. Vet Microbiol 2010 Jul 29;144(1-2):236-9.
    doi: 10.1016/j.vetmic.2009.12.040pmc: PMC7126194pubmed: 20106608google scholar: lookup
  6. Yamaguchi R, Nakamura S, Hori H, Kato Y, Une Y. Purulent meningoventriculitis caused by Streptococcus equi subspecies zooepidemicus in a snow leopard (Panthera uncia).. J Comp Pathol 2012 Aug-Oct;147(2-3):397-400.
    doi: 10.1016/j.jcpa.2012.02.002pubmed: 22516084google scholar: lookup
  7. Costa MO, Lage B. Streptococcus equi Subspecies zooepidemicus and Sudden Deaths in Swine, Canada.. Emerg Infect Dis 2020 Oct;26(10):2522-2524.
    doi: 10.3201/eid2610.191485pmc: PMC7510724pubmed: 32946731google scholar: lookup
  8. Sitthicharoenchai P, Derscheid R, Schwartz K, Macedo N, Sahin O, Chen X, Li G, Main R, Burrough E. Cases of high mortality in cull sows and feeder pigs associated with Streptococcus equi subsp. zooepidemicus septicemia.. J Vet Diagn Invest 2020 Jul;32(4):565-571.
    doi: 10.1177/1040638720927669pmc: PMC7438661pubmed: 32532177google scholar: lookup
  9. Gruszynski K, Young A, Levine SJ, Garvin JP, Brown S, Turner L, Fritzinger A, Gertz RE Jr, Murphy JM, Vogt M, Beall B. Streptococcus equi subsp. zooepidemicus infections associated with guinea pigs.. Emerg Infect Dis 2015 Jan;21(1):156-8.
    doi: 10.3201/eid2101.140640pmc: PMC4285269pubmed: 25531424google scholar: lookup
  10. Las Heras A, Vela AI, Fernández E, Legaz E, Domínguez L, Fernández-Garayzábal JF. Unusual outbreak of clinical mastitis in dairy sheep caused by Streptococcus equi subsp. zooepidemicus.. J Clin Microbiol 2002 Mar;40(3):1106-8.
    doi: 10.1128/JCM.40.3.1106-1108.2002pmc: PMC120234pubmed: 11880454google scholar: lookup
  11. Pisoni G, Zadoks RN, Vimercati C, Locatelli C, Zanoni MG, Moroni P. Epidemiological investigation of Streptococcus equi subspecies zooepidemicus involved in clinical mastitis in dairy goats.. J Dairy Sci 2009 Mar;92(3):943-51.
    doi: 10.3168/jds.2008-1548pubmed: 19233787google scholar: lookup
  12. Corpa JM, Carvallo F, Anderson ML, Nyaoke AC, Moore JD, Uzal FA. Streptococcus equi subspecies zooepidemicus septicemia in alpacas: three cases and review of the literature.. J Vet Diagn Invest 2018 Jul;30(4):598-602.
    doi: 10.1177/1040638718772071pmc: PMC6505895pubmed: 29717639google scholar: lookup
  13. Mätz-Rensing K, Winkelmann J, Becker T, Burckhardt I, van der Linden M, Köndgen S, Leendertz F, Kaup FJ. Outbreak of Streptococcus equi subsp. zooepidemicus infection in a group of rhesus monkeys (Macaca mulatta).. J Med Primatol 2009 Oct;38(5):328-34.
    doi: 10.1111/j.1600-0684.2009.00359.xpmc: PMC7166853pubmed: 19508349google scholar: lookup
  14. Nocera FP, Ambrosio M, Conte A, Di Palma T, Castaldo S, Pasolini MP, Fiorito F, De Martino L. Importance of broth-enrichment culture in equine endometritis diagnosis.. New Microbiol 2021 Jan;44(1):19-23.
    pubmed: 33582824
  15. Timoney JF. The pathogenic equine streptococci.. Vet Res 2004 Jul-Aug;35(4):397-409.
    doi: 10.1051/vetres:2004025pubmed: 15236673google scholar: lookup
  16. Kawakami V, Rietberg K, Lipton B, Eckmann K, Watkins M, Oltean H, Kay M, Rothschild C, Kobayashi M, Van Beneden C, Duchin J. Notes from the Field: Fatal Infection Associated with Equine Exposure - King County, Washington, 2016.. MMWR Morb Mortal Wkly Rep 2016 Aug 5;65(30):788.
    doi: 10.15585/mmwr.mm6530a5pubmed: 27490189google scholar: lookup
  17. Høyer-Nielsen AK, Gaini S, Kjerulf A, Kollslíð R, Steig TÁ, Stegger M, Jóanesarson J. Sepsis, Endocarditis, and Purulent Arthritis due to a Rare Zoonotic Infection with Streptococcus equi Subspecies zooepidemicus.. Case Rep Infect Dis 2018;2018:3265701.
    doi: 10.1155/2018/3265701pmc: PMC6022317pubmed: 30013802google scholar: lookup
  18. Kittang BR, Pettersen VK, Oppegaard O, Skutlaberg DH, Dale H, Wiker HG, Skrede S. Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer.. BMC Infect Dis 2017 Feb 15;17(1):147.
    doi: 10.1186/s12879-017-2262-7pmc: PMC5312586pubmed: 28201995google scholar: lookup
  19. Abbott Y, Acke E, Khan S, Muldoon EG, Markey BK, Pinilla M, Leonard FC, Steward K, Waller A. Zoonotic transmission of Streptococcus equi subsp. zooepidemicus from a dog to a handler.. J Med Microbiol 2010 Jan;59(Pt 1):120-123.
    doi: 10.1099/jmm.0.012930-0pubmed: 19745031google scholar: lookup
  20. Zahlanie Y, Almatrafi M, Filkins L, Hsiang MS. Possible canine source of Streptococcus equi subspecies zooepidemicus causing meningitis in an infant.. IDCases 2019;17:e00568.
    doi: 10.1016/j.idcr.2019.e00568pmc: PMC6555896pubmed: 31194131google scholar: lookup
  21. Balter S, Benin A, Pinto SW, Teixeira LM, Alvim GG, Luna E, Jackson D, LaClaire L, Elliott J, Facklam R, Schuchat A. Epidemic nephritis in Nova Serrana, Brazil.. Lancet 2000 May 20;355(9217):1776-80.
    pubmed: 10832828doi: 10.1016/s0140-6736(00)02265-0google scholar: lookup
  22. Bordes-Benítez A, Sánchez-Oñoro M, Suárez-Bordón P, García-Rojas AJ, Saéz-Nieto JA, González-García A, Alamo-Antúnez I, Sánchez-Maroto A, Bolaños-Rivero M. Outbreak of Streptococcus equi subsp. zooepidemicus infections on the island of Gran Canaria associated with the consumption of inadequately pasteurized cheese.. Eur J Clin Microbiol Infect Dis 2006 Apr;25(4):242-6.
    doi: 10.1007/s10096-006-0119-xpubmed: 16550347google scholar: lookup
  23. Hughes JP, Loy RG. Investigations on the effect on intrauterine inoculation of Streptococcus zooepidemicus in the mare.. Proc. Am. Assoc. Equine Pract. 1969;15:289–292.
  24. Trotter GW, McKinnon AO. Surgery for abnormal vulvar and perineal conformation in the mare.. Vet Clin North Am Equine Pract 1988 Dec;4(3):389-405.
    doi: 10.1016/S0749-0739(17)30618-1pubmed: 3061601google scholar: lookup
  25. Canisso IF, Stewart J, Coutinho da Silva MA. Endometritis: Managing Persistent Post-Breeding Endometritis.. Vet Clin North Am Equine Pract 2016 Dec;32(3):465-480.
    doi: 10.1016/j.cveq.2016.08.004pubmed: 27810036google scholar: lookup
  26. Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology.. Int J Mol Sci 2020 Feb 20;21(4).
    doi: 10.3390/ijms21041432pmc: PMC7073041pubmed: 32093296google scholar: lookup
  27. Rasmussen CD, Haugaard MM, Petersen MR, Nielsen JM, Pedersen HG, Bojesen AM. Streptococcus equi subsp. zooepidemicus isolates from equine infectious endometritis belong to a distinct genetic group.. Vet Res 2013 Apr 18;44(1):26.
    doi: 10.1186/1297-9716-44-26pmc: PMC3640914pubmed: 23597033google scholar: lookup
  28. Petersen MR, Skive B, Christoffersen M, Lu K, Nielsen JM, Troedsson MH, Bojesen AM. Activation of persistent Streptococcus equi subspecies zooepidemicus in mares with subclinical endometritis.. Vet Microbiol 2015 Aug 31;179(1-2):119-25.
    doi: 10.1016/j.vetmic.2015.06.006pubmed: 26123371google scholar: lookup
  29. Maisonneuve E, Gerdes K. Molecular mechanisms underlying bacterial persisters.. Cell 2014 Apr 24;157(3):539-48.
    doi: 10.1016/j.cell.2014.02.050pubmed: 24766804google scholar: lookup
  30. Cattoir V. Mechanisms of Antibiotic Resistance.. Streptococcus pyogenes: Basic Biology to Clinical Manifestations University of Oklahoma Health Sciences Center; Oklahoma City, OK, USA: 2016.
    pubmed: 26866208
  31. Alves-Barroco C, Rivas-García L, Fernandes AR, Baptista PV. Tackling Multidrug Resistance in Streptococci - From Novel Biotherapeutic Strategies to Nanomedicines.. Front Microbiol 2020;11:579916.
    doi: 10.3389/fmicb.2020.579916pmc: PMC7573253pubmed: 33123110google scholar: lookup
  32. Petersen MR, Nielsen JM, Lehn-Jensen H, Bojesen AM. Streptococcus equi subspecies zooepidemicus resides deep in the chronically infected endometrium of mares.. Clin. Theriogenol. 2009;1:393–409.
  33. Nielsen JM, Troedsson MH, Pedersen MR, Miki Bojesen A, Lehn-Jensen H, Zent WW. Diagnosis of endometritis in the mare based on bacteriological and cytological examinations of the endometrium: Comparison of results obtained by swabs and biopsies.. J. Equine Vet. Sci. 2010;30:27–30.
    doi: 10.1016/j.jevs.2009.11.006google scholar: lookup
  34. Skive B, Rohde M, Molinari G, Braunstein TH, Bojesen AM. Streptococcus equi subsp. zooepidemicus Invades and Survives in Epithelial Cells.. Front Cell Infect Microbiol 2017;7:465.
    doi: 10.3389/fcimb.2017.00465pmc: PMC5681531pubmed: 29164073google scholar: lookup
  35. Kudirkiene E, Welker M, Knudsen NR, Bojesen AM. Rapid and accurate identification of Streptococcus equi subspecies by MALDI-TOF MS.. Syst Appl Microbiol 2015 Jul;38(5):315-22.
    doi: 10.1016/j.syapm.2015.02.010pubmed: 25944783google scholar: lookup
  36. Mani RJ, Thachil AJ, Ramachandran A. Discrimination of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.. J Vet Diagn Invest 2017 Sep;29(5):622-627.
    doi: 10.1177/1040638717702687pubmed: 28460559google scholar: lookup
  37. Johns IC, Adams EL. Trends in antimicrobial resistance in equine bacterial isolates: 1999-2012.. Vet Rec 2015 Mar 28;176(13):334.
    doi: 10.1136/vr.102708pubmed: 25628448google scholar: lookup
  38. Pisello L, Rampacci E, Stefanetti V, Beccati F, Hyatt DR, Coletti M, Passamonti F. Temporal efficacy of antimicrobials against aerobic bacteria isolated from equine endometritis: an Italian retrospective analysis (2010-2017).. Vet Rec 2019 Nov 16;185(19):598.
    doi: 10.1136/vr.105413pubmed: 31409748google scholar: lookup
  39. Wilson DW. Rational selection of antimicrobials for use in horses.. AAEP Proc. 2001;47:75–93.
  40. Boyle AG, Timoney JF, Newton JR, Hines MT, Waller AS, Buchanan BR. Streptococcus equi Infections in Horses: Guidelines for Treatment, Control, and Prevention of Strangles-Revised Consensus Statement.. J Vet Intern Med 2018 Mar;32(2):633-647.
    doi: 10.1111/jvim.15043pmc: PMC5867011pubmed: 29424487google scholar: lookup
  41. Bade D, Portis E, Keane C, Hallberg J, Bryson L, Sweeney M, Boner P. In vitro susceptibility of ceftiofur against Streptococcus equi subsp zooepidemicus and subsp equi isolated from horses with lower respiratory disease in Europe since 2002.. Vet Ther 2009 Winter;10(4):E1-10.
    pubmed: 20425729
  42. McClure S, Sibert G, Hallberg J, Bade D. Efficacy of a 2-dose regimen of a sustained release ceftiofur suspension in horses with Streptococcus equi subsp. zooepidemicus bronchopneumonia.. J Vet Pharmacol Ther 2011 Oct;34(5):442-7.
    doi: 10.1111/j.1365-2885.2011.01267.xpubmed: 21303377google scholar: lookup
  43. World Health Organization, WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR). Critically Important Antimicrobials for Human Medicine: Ranking of Antimicrobial Agents for Risk Management of Antimicrobial Resistance due to Non-Human Use.. World Health Organization 5th ed. World Health Organization; Geneva, Switzerland: 2017.
  44. Bidell MR, Palchak M, Mohr J, Lodise TP. Fluoroquinolone and Third-Generation-Cephalosporin Resistance among Hospitalized Patients with Urinary Tract Infections Due to Escherichia coli: Do Rates Vary by Hospital Characteristics and Geographic Region?. Antimicrob Agents Chemother 2016 May;60(5):3170-3.
    doi: 10.1128/AAC.02505-15pmc: PMC4862467pubmed: 26926640google scholar: lookup
  45. Shnaiderman-Torban A, Marchaim D, Navon-Venezia S, Lubrani O, Paitan Y, Arielly H, Steinman A. Third Generation Cephalosporin Resistant Enterobacterales Infections in Hospitalized Horses and Donkeys: A Case-Case-Control Analysis.. Antibiotics (Basel) 2021 Feb 4;10(2).
    doi: 10.3390/antibiotics10020155pmc: PMC7913880pubmed: 33557061google scholar: lookup
  46. Feary DJ, Hyatt D, Traub-Dargatz J, Roach S, Jones RL, Wu CC, Morley PS. Investigation of falsely reported resistance of Streptococcus equi subsp. zooepidemicus isolates from horses to trimethoprim-sulfamethoxazole.. J Vet Diagn Invest 2005 Sep;17(5):483-6.
    doi: 10.1177/104063870501700515pubmed: 16312244google scholar: lookup
  47. Pelkonen S, Lindahl SB, Suomala P, Karhukorpi J, Vuorinen S, Koivula I, Väisänen T, Pentikäinen J, Autio T, Tuuminen T. Transmission of Streptococcus equi subspecies zooepidemicus infection from horses to humans.. Emerg Infect Dis 2013 Jul;19(7):1041-8.
    doi: 10.3201/eid1907.121365pmc: PMC3713971pubmed: 23777752google scholar: lookup
  48. Sleutjens J, Meijer D, Meregalli PG, Bakker L, Wagenaar JA, Duim B, Zomer A. Zoonotic Endocarditis in a Man, the Netherlands.. Emerg Infect Dis 2019 Jan;25(1):180-182.
    doi: 10.3201/eid2501.181029pmc: PMC6302571pubmed: 30561307google scholar: lookup
  49. Gade PV, Witten AJ, Ninad N. A Confirmed Case of Zoonotic Aortitis and Successful Repair with an Allograft.. EJVES Vasc Forum 2020;47:26-29.
    doi: 10.1016/j.ejvsvf.2020.02.004pmc: PMC7287342pubmed: 32881989google scholar: lookup
  50. Sevilla-Acosta F, Ballestero-Pernudi A, Jiménez-Cruz E, Álvarez-Cabalceta H, Naranjo-Zuñiga G. Streptococcus equi subspecies zooepidemicus Meningitis, Septicemia, and Brain Infarcts in a Costa Rican Infant.. Cureus 2021 Aug;13(8):e17286.
    doi: 10.7759/cureus.17286pmc: PMC8448576pubmed: 34552827google scholar: lookup
  51. . Performance Standards for Antimicrobial Susceptibility Testing.. Clinical and Laboratory Standards Institute Wayne, IL, USA: 2018.
  52. The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint Tables for Interpretation of MICs and Zone Diameters.. EUCAST EUCAST; Växjö, Sweden: 2018.
  53. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.. Clin Microbiol Infect 2012 Mar;18(3):268-81.
    doi: 10.1111/j.1469-0691.2011.03570.xpubmed: 21793988google scholar: lookup

Citations

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  1. Köhne M, Hofbauer L, Böttcher D, Tönissen A, Hegger A, Görgens A, Ulrich R, Sieme H. Comparison of systemic trimethoprim-sulfadimethoxine treatment and intrauterine ozone application as possible therapies for bacterial endometritis in equine practice. Front Vet Sci 2023;10:1102149.
    doi: 10.3389/fvets.2023.1102149pubmed: 36777673google scholar: lookup
  2. Khalid E, Tartor YH, Ammar AM, Abdelaziz R, Mahmmod Y, Abdelkhalek A. Controlling drug-resistant bacteria in Arabian horses: bacteriophage cocktails for treating wound infections. Front Vet Sci 2025;12:1609955.
    doi: 10.3389/fvets.2025.1609955pubmed: 41169678google scholar: lookup
  3. Alessiani A, Baffoni M, Averaimo D, Cantelmi MC, Coccaro A, Rulli M, Piersanti V, Pompilii C, Cito F, Chiaverini A, Petrini A. Antimicrobial Resistance and Genetic Characterization of Streptococcus equi subsp. zooepidemicus in Equines from Central Italy: Insights from a One Health Perspective. Animals (Basel) 2025 Sep 16;15(18).
    doi: 10.3390/ani15182713pubmed: 41007958google scholar: lookup
  4. Del Prete C, Attolini E, Merlo B, Iacono E, Nocera FP, De Martino L, Longobardi C, Damiano S, Longobardi V, Cocchia N, Pasolini MP. Post-Insemination Infusion of Wharton's Jelly Mesenchymal Stromal/Stem Cells-Derived Conditioned Medium: A Novel Approach for Improving Pregnancy Outcomes in Problem Mares. Vet Sci 2025 May 16;12(5).
    doi: 10.3390/vetsci12050482pubmed: 40431575google scholar: lookup
  5. Kabir A, Lamichhane B, Habib T, Adams A, El-Sheikh Ali H, Slovis NM, Troedsson MHT, Helmy YA. Antimicrobial Resistance in Equines: A Growing Threat to Horse Health and Beyond-A Comprehensive Review. Antibiotics (Basel) 2024 Jul 29;13(8).
    doi: 10.3390/antibiotics13080713pubmed: 39200013google scholar: lookup
  6. Shah N, Al Janabi T, Lien E, Thimmapuram J. A Rare Case of Streptococcus equi Subspecies Zooepidemicus Bacteremia. Cureus 2024 May;16(5):e59911.
    doi: 10.7759/cureus.59911pubmed: 38854287google scholar: lookup
  7. Prete CD, Nocera FP, Piegari G, Palumbo V, Martino L, Cocchia N, Paciello O, Montano C, Pasolini MP. Use of cytobrush for bacteriological and cytological diagnosis of endometritis in mares. Vet World 2024 Feb;17(2):398-406.
    doi: 10.14202/vetworld.2024.398-406pubmed: 38595673google scholar: lookup
  8. Cantelmi MC, Merola C, Averaimo D, Chiaverini A, Cito F, Cocco A, Di Teodoro G, De Angelis ME, Di Bernardo D, Auzino D, Petrini A. Identification of the Novel Streptococcus equi subsp. zooepidemicus Sequence Type 525 in Donkeys of Abruzzo Region, Italy. Pathogens 2023 May 23;12(6).
    doi: 10.3390/pathogens12060750pubmed: 37375440google scholar: lookup
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