Occurrence of nervous-tissue tumors in cattle, horses, cats and dogs.
Abstract: From 11 North American veterinary university hospitals and clinics, 248 animals were a confirmed diagnosis of nervous-tissue tumor were identified; 7 tumors were found in cattle, 28 in horses, 14 in cats, 199 in dogs, and none in other species. Tumors were divided for analysis into three categories-glial, meningeal, and peripheral nerve. In cattle and horses, all tumors involved peripheral nerves, the risk of which, in horses, reached a plateau at 4-6 years of age and remained constant thereafter. In cats, the tumors were equally distributed among the three tumor categories whereas, in dogs, twice as many glial tumors as meningeal and peripheral nerve tumors were found. The risk for glial tumors in dogs reached a peak at 10-14 years of age, for meningeal at 7-9 years, and for peripheral nerve at 2-3 and 7-9 years. Three canine breeds-English bulldog, boxer, and Boston terrier-had an excessive rish of glial tumors. Except for an excess of skin tumors in dogs with peripheral nerve tumors, there was no unusual occurrence with second primary neoplasms for any species. There was no detectable predisposition by sex for any of the categories of nervous-tissue tumors among any of the four species. The role of genetic abnormalities associated with nervous-tissue tumors and other etiologic factors (e.g., chronic hypoxia) may be clarified by further studies involving canine breeds of "bulldog" ancestry.
Publication Date: 1975-01-15 PubMed ID: 165149DOI: 10.1002/ijc.2910150106Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study examines the occurrence of nervous-tissue tumors in various animal species, mainly focusing on cattle, horses, cats and dogs. Researchers analyzed cases of these tumors obtained from 11 North American veterinary university hospitals and clinics and categorized them into three groups – glial, meningeal, and peripheral nerve tumors.
Methodology And Findings
- The researchers collectively recorded 248 cases of confirmed nervous-tissue tumors from veterinary university hospitals and clinics across North America.
- These cases were broken down into cattle (7), horses (28), cats (14), and dogs (199), with no nervous-tissue tumors being recorded in other species.
- The tumours were categorized into three main types for analysis purposes: glial (brain-specific), meningeal (related to the meninges of the brain), and peripheral nerve tumours.
Species-specific Observations
- In cattle and horses, all tumors were found to involve peripheral nerves.
- In horses, the risk of peripheral nerve tumors appeared to plateau between ages 4-6 and stayed consistent thereafter.
- Cats showed an equal distribution of tumours among the three categories.
- Dogs, however, had twice as many glial tumors as they had meningeal and peripheral nerve tumors.
- Within canines, the risk for different types of tumours peaked at different ages, with glial tumors peaking at 10-14 years, meningeal tumors at 7-9 years, and peripheral nerve tumors at 2-3 and then again at 7-9 years.
- The English bulldog, boxer, and Boston terrier breeds were identified as having an excessive risk of glial tumours.
- Aside from an excess of skin tumors found in dogs with peripheral nerve tumors, there wasn’t an unusual occurrence of secondary primary neoplasms in any species.
Genetic and Etiologic Factors
- No clear predisposition by sex was detected for any categories of nervous-tissue tumors among the four species studied.
- The researchers suggest that further study into canine breeds of “bulldog” ancestry could help clarify the role of genetic abnormalities associated with nervous-tissue tumors and other causative factors, such as chronic hypoxia.
Cite This Article
APA
Hayes HM, Priester WA, Pendergrass TW.
(1975).
Occurrence of nervous-tissue tumors in cattle, horses, cats and dogs.
Int J Cancer, 15(1), 39-47.
https://doi.org/10.1002/ijc.2910150106 Publication
Researcher Affiliations
MeSH Terms
- Age Factors
- Animals
- Astrocytoma / epidemiology
- Astrocytoma / veterinary
- Cat Diseases / epidemiology
- Cats
- Cattle
- Cattle Diseases / epidemiology
- Dog Diseases / epidemiology
- Dogs
- Ependymoma / epidemiology
- Ependymoma / veterinary
- Glioma / epidemiology
- Glioma / veterinary
- Horse Diseases / epidemiology
- Horses
- Medulloblastoma / epidemiology
- Medulloblastoma / veterinary
- Meningioma / epidemiology
- Meningioma / veterinary
- Neoplasms, Multiple Primary
- Neoplasms, Nerve Tissue / epidemiology
- Neoplasms, Nerve Tissue / veterinary
- Sex Factors
- Species Specificity
- United States
Citations
This article has been cited 20 times.- Hanael E, Baruch S, Chai O, Lishitsky L, Blum T, Rapoport K, Ruggeri M, Aizenberg Z, Peery D, Meyerhoff N, Volk HA, De Decker S, Tipold A, Baumgaertner W, Friedman A, Shamir M. Quantitative analysis of magnetic resonance images for characterization of blood-brain barrier dysfunction in dogs with brain tumors.. J Vet Intern Med 2023 Mar;37(2):606-617.
- Loncarica T, Balducci F, Bernardini M. Prevalence of idiopathic epilepsy and structural epilepsy in 74 Boxer dogs in a referral hospital.. Front Vet Sci 2022;9:956648.
- Hidalgo Crespo E, Farré Mariné A, Pumarola I Battle M, Borrego Massó JF, Luján Feliu-Pascual A. Survival Time after Surgical Debulking and Temozolomide Adjuvant Chemotherapy in Canine Intracranial Gliomas.. Vet Sci 2022 Aug 12;9(8).
- Pons-Sorolla M, Dominguez E, Czopowicz M, Suñol A, Maeso Ordás C, Morales Moliner C, Pérez Soteras M, Montoliu P. Clinical and Magnetic Resonance Imaging (MRI) Features, Tumour Localisation, and Survival of Dogs with Presumptive Brain Gliomas.. Vet Sci 2022 May 27;9(6).
- Jahns H, McElroy MC. Bovine intracranial neoplasia: A retrospective case series.. Vet Pathol 2022 Sep;59(5):824-835.
- José-López R, Gutierrez-Quintana R, de la Fuente C, Manzanilla EG, Suñol A, Pi Castro D, Añor S, Sánchez-Masian D, Fernández-Flores F, Ricci E, Marioni-Henry K, Mascort J, Matiasek LA, Matiasek K, Brennan PM, Pumarola M. Clinical features, diagnosis, and survival analysis of dogs with glioma.. J Vet Intern Med 2021 Jul;35(4):1902-1917.
- Kishimoto TE, Uchida K, Chambers JK, Kok MK, Son NV, Shiga T, Hirabayashi M, Ushio N, Nakayama H. A retrospective survey on canine intracranial tumors between 2007 and 2017.. J Vet Med Sci 2020 Jan 17;82(1):77-83.
- Miller AD, Miller CR, Rossmeisl JH. Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors.. Front Oncol 2019;9:1151.
- Partridge B, Rossmeisl JH Jr. Companion animal models of neurological disease.. J Neurosci Methods 2020 Feb 1;331:108484.
- Muñoz-Gutiérrez JF, Garner MM, Kiupel M. Primary central nervous system neoplasms in African hedgehogs.. J Vet Diagn Invest 2018 Sep;30(5):715-720.
- Truvé K, Dickinson P, Xiong A, York D, Jayashankar K, Pielberg G, Koltookian M, Murén E, Fuxelius HH, Weishaupt H, Swartling FJ, Andersson G, Hedhammar Å, Bongcam-Rudloff E, Forsberg-Nilsson K, Bannasch D, Lindblad-Toh K. Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.. PLoS Genet 2016 May;12(5):e1006000.
- Olin MR, Pluhar GE, Andersen BM, Shaver R, Waldron NN, Moertel CL. Victory and defeat in the induction of a therapeutic response through vaccine therapy for human and canine brain tumors: a review of the state of the art.. Crit Rev Immunol 2014;34(5):399-432.
- Dickinson PJ. Advances in diagnostic and treatment modalities for intracranial tumors.. J Vet Intern Med 2014 Jul-Aug;28(4):1165-85.
- Debinski W, Dickinson P, Rossmeisl JH, Robertson J, Gibo DM. New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors.. PLoS One 2013;8(10):e77719.
- Bannasch D, Young A, Myers J, Truvé K, Dickinson P, Gregg J, Davis R, Bongcam-Rudloff E, Webster MT, Lindblad-Toh K, Pedersen N. Localization of canine brachycephaly using an across breed mapping approach.. PLoS One 2010 Mar 10;5(3):e9632.
- Egenvall A, Nødtvedt A, Penell J, Gunnarsson L, Bonnett BN. Insurance data for research in companion animals: benefits and limitations.. Acta Vet Scand 2009 Oct 29;51(1):42.
- Josephson GK, Little PB. Four bovine meningeal tumors.. Can Vet J 1990 Oct;31(10):700-3.
- Komarnisky MD. Astrocytoma in a cat.. Can Vet J 1985 Aug;26(8):237-40.
- Madewell BR. Neoplasms in domestic animals: a review of experimental and spontaneous carcinogenesis.. Yale J Biol Med 1981 Mar-Apr;54(2):111-25.
- Vandevelde M, Fankhauser R, Luginbühl H. Immunocytochemical studies in canine neuroectodermal brain tumors.. Acta Neuropathol 1985;66(2):111-6.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
