Ocular and periocular hemangiosarcoma in six horses.
Abstract: To determine the characteristics of and prognosis for ocular and periocular hemangiosarcoma in horses. Methods: Six horses treated for ocular or periocular hemangiosarcoma. Methods: A retrospective review of medical records from 2007 to 2015 was performed to identify horses with a histologic diagnosis of ocular or periocular hemangiosarcoma. Signalment (age, sex, breed), duration of clinical signs, prior treatment, tumor size and location, medical and surgical treatment including postoperative chemotherapy, follow-up time, and outcome were obtained from medical records. Histopathology was reviewed by a board-certified pathologist. Results: In six horses diagnosed with ocular or periocular hemangiosarcoma, no breed, age, or sex was overrepresented. Sites included the temporal limbus (3), third eyelid (2), and uvea (1). With the exception of one horse with uveal hemangiosarcoma, 5/6 horses had lightly pigmented periocular haircoat. Histologic features of ocular hemangiosarcoma in 6/6 cases included high cellularity, nuclear pleomorphism, and inflammation with a mitotic index ranging from 0 to 8 mitoses per 10 consecutive 400× fields. Five of six tumors displayed solar elastosis, indicating ultraviolet light-induced damage to sub-epithelial collagen. Treatment included surgical excision in all cases and was not associated with recurrence in 4/6. Three cases that received ancillary treatment with topical mitomycin C had no postoperative recurrence. Two cases with postexcisional recurrence had histologic evidence of incomplete excision. Conclusions: Complete surgical excision may be associated with resolution of periocular and ocular hemangiosarcoma in horses. Etiopathogenesis may include exposure to ultraviolet light.
© 2017 American College of Veterinary Ophthalmologists.
Publication Date: 2017-11-07 PubMed ID: 29111617DOI: 10.1111/vop.12529Google Scholar: Lookup
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Summary
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The research article discusses the characteristics and prognosis of ocular and periocular hemangiosarcoma (a form of cancer) in horses based on a study of six individual cases, emphasizing on complete surgical excisions as a potential effective approach for treatment.
Research Method
- The researchers conducted a retrospective review of medical records from 2007 to 2015, looking specifically for horses with a histological diagnosis of ocular or periocular hemangiosarcoma.
- Data collected for each horse included: age, sex, breed, duration of clinical signs, prior treatment received, tumor size and location, medical and surgical treatments including postoperative chemotherapy, follow-up time, and outcome.
- All the collected histopathologies were reviewed by a board-certified pathologist.
Research Findings
- There were no consistent patterns in terms of the breed, age, or sex of horses diagnosed with ocular or periocular hemangiosarcoma among the six cases studied.
- The locations of the tumors varied: three in the temporal limbus, two in the third eyelid, and one in the uvea. Except for the horse with uveal hemangiosarcoma, the rest had lightly pigmented periocular haircoats.
- Pathologically, the hemangiosarcomas in all six horses showed high cellularity, nuclear pleomorphism, and inflammation. These characteristics were confirmed using a measure called the mitotic index, which ranged from 0 to 8 mitoses per 10 consecutive 400x microscopic fields.
- Five out of the six tumors showed signs of solar elastosis, indicating ultraviolet light-induced damage to the sub-epithelial collagen, suggesting exposure to ultraviolet light may contribute to the disease’s development.
Treatment and Outcome
- All six cases underwent surgical excision. Four out of six horses did not experience a recurrence of the tumor following the surgery.
- Three cases also received ancillary treatment with topical mitomycin C, a chemotherapy agent, and none of them had a recurrence of the disease postoperatively.
- In two cases where the disease did recur after surgery, there was histologic evidence indicating that the excision was not fully completed.
- The investigators concluded that complete surgical excision could be an effective treatment for ocular and periocular hemangiosarcoma in horses.
Cite This Article
APA
Scherrer NM, Lassaline M, Engiles J.
(2017).
Ocular and periocular hemangiosarcoma in six horses.
Vet Ophthalmol, 21(4), 432-437.
https://doi.org/10.1111/vop.12529 Publication
Researcher Affiliations
- Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA, 19348, USA.
- Department of Radiological and Surgical Sciences, University of California-Davis, 944 Garrod Drive, Davis, CA, 95616, USA.
- Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA, 19348, USA.
- Department of Pathobiology, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA, 19348, USA.
MeSH Terms
- Animals
- Eye Neoplasms / diagnosis
- Eye Neoplasms / pathology
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Hemangiosarcoma / diagnosis
- Hemangiosarcoma / pathology
- Hemangiosarcoma / surgery
- Hemangiosarcoma / veterinary
- Horse Diseases / diagnosis
- Horse Diseases / pathology
- Horse Diseases / surgery
- Horses
- Male
- Prognosis
- Retrospective Studies
- Treatment Outcome
Citations
This article has been cited 3 times.- Parisi F, Abramo F, Maimone M, Poli A, Millanta F. Skin Photodamage Lesions in a Bilateral Feline Auricular Primary Fibrosarcoma.. Vet Sci 2022 Oct 5;9(10).
- Millanta F, Parisi F, Poli A, Sorelli V, Abramo F. Auricular Non-Epithelial Tumors with Solar Elastosis in Cats: A Possible UV-Induced Pathogenesis.. Vet Sci 2022 Jan 18;9(2).
- Blohm KO, Tichy A, Nell B. Clinical utility, dose determination, and safety of ocular contrast-enhanced ultrasonography in horses: A pilot study.. Vet Ophthalmol 2020 Mar;23(2):331-340.
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